Gene name: SCH9
Reference locus (S288C): YHR205W
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase SCH9; AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
Top 10 interactors (score): TOR1 (0.999); TOR2 (0.998); KOG1 (0.997); LST8 (0.993); TSC11 (0.99); GIS1 (0.988); AVO1 (0.988); RAS2 (0.984); RIM15 (0.977); CYR1 (0.962); TAP42 (0.959); MAF1 (0.958); SFP1 (0.958); MSN2 (0.955); MSN4 (0.953); BIT61 (0.947); BCK1 (0.944); SLT2 (0.94); GTR1 (0.936); SIT4 (0.935)
Homologues (species, bitscore): AKT1 (Homo sapiens, 307.0); Akt1 (Mus musculus, 305.8); akt2 (Danio rerio, 305.4); akt1 (Xenopus tropicalis, 308.5); Akt1 (Drosophila melanogaster, 312.8); rsks-1 (Caenorhabditis elegans, 306.2); S6K2 (Arabidopsis thaliana, 281.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:496421-498895:+ | gene-YHR205W_AKU4011 | rna-NM_001179336.1_AKU4011 | cds-NP_012075.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:18839-21313:- | gene-YHR205W_BG1 | rna-NM_001179336.1_BG1 | cds-NP_012075.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:503911-506385:+ | gene-YHR205W_Bruggeman | rna-NM_001179336.1_Bruggeman | cds-NP_012075.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:500464-502938:+ | gene-YHR205W_CAT1 | rna-NM_001179336.1_CAT1 | cds-NP_012075.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:495857-498331:+ | gene-YHR205W_CBS1585 | rna-NM_001179336.1_CBS1585 | cds-NP_012075.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:493962-496436:+ | gene-YHR205W_CBS436 | rna-NM_001179336.1_CBS436 | cds-NP_012075.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:495974-498448:+ | gene-YHR205W_CBS6412 | rna-NM_001179336.1_CBS6412 | cds-NP_012075.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:497228-499702:+ | gene-YHR205W_CBS6413 | rna-NM_001179336.1_CBS6413 | cds-NP_012075.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:502586-505060:+ | gene-YHR205W_CENPK1137D | rna-NM_001179336.1_CENPK1137D | cds-NP_012075.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:554975-557449:+ | gene-YHR205W_EthanolRed | rna-NM_001179336.1_EthanolRed | cds-NP_012075.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:497426-499900:+ | gene-YHR205W_FaliES1 | rna-NM_001179336.1_FaliES1 | cds-NP_012075.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000071.1:4189-6663:+ | gene-YHR205W_JAY291 | rna-NM_001179336.1_JAY291 | cds-NP_012075.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:505006-507480:+ | gene-YHR205W_MUCL30387 | rna-NM_001179336.1_MUCL30387 | cds-NP_012075.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:504667-507141:+ | gene-YHR205W_MUCL30388 | rna-NM_001179336.1_MUCL30388 | cds-NP_012075.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:495974-498448:+ | gene-YHR205W_MUCL39482 | rna-NM_001179336.1_MUCL39482 | cds-NP_012075.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:511305-513779:+ | gene-YHR205W_MUCL42920 | rna-NM_001179336.1_MUCL42920 | cds-NP_012075.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:509245-511719:+ | gene-YHR205W_NCIM3186 | rna-NM_001179336.1_NCIM3186 | cds-NP_012075.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:498262-500736:+ | gene-YHR205W_NCYC1407 | rna-NM_001179336.1_NCYC1407 | cds-NP_012075.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:497438-499912:+ | gene-YHR205W_PE2H3 | rna-NM_001179336.1_PE2H3 | cds-NP_012075.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:504865-507339:+ | gene-YHR205W_PE2H4 | rna-NM_001179336.1_PE2H4 | cds-NP_012075.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:509363-511837:+ | gene-YHR205W_S288C | rna-NM_001179336.1_S288C | cds-NP_012075.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000112.1:4255-6729:+ | gene-YHR205W_SA1 | rna-NM_001179336.1_SA1 | cds-NP_012075.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:498695-501169:+ | gene-YHR205W_ThermosaccDry | rna-NM_001179336.1_ThermosaccDry | cds-NP_012075.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:507704-510178:+ | gene-YHR205W_VR1 | rna-NM_001179336.1_VR1 | cds-NP_012075.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:488747-491222:+ | gene-YHR205W_ZTW1 | rna-NM_001179336.1_ZTW1 | cds-NP_012075.1_ZTW1 | 99.6 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:495442-497919:+ | gene-YHR205W_Sparadoxus | rna-NM_001179336.1_Sparadoxus | cds-NP_012075.1_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |