Gene name: SCC2
Reference locus (S288C): YDR180W
Gene biotype: protein_coding
Description: Sister chromatid cohesion protein 2; Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2
Top 10 interactors (score): PDS5 (0.999); IRR1 (0.999); SMC1 (0.999); SMC3 (0.999); MCD1 (0.999); SCC4 (0.997); SMC5 (0.992); ESP1 (0.972); SMC4 (0.97); ECO1 (0.966); SET2 (0.961); PAN3 (0.923); SEN1 (0.923); SEC7 (0.916); SMC6 (0.909); YCS4 (0.908); ULP2 (0.902); THO2 (0.901); CHL1 (0.866); CTF4 (0.856)
Homologues (species, bitscore): NIPBL (Homo sapiens, 79.7); Nipbl (Mus musculus, 81.3); nipbla (Danio rerio, 77.4); nipbl (Xenopus tropicalis, 77.4); Nipped-B (Drosophila melanogaster, 63.5); pqn-85 (Caenorhabditis elegans, 87.0); EMB2773 (Arabidopsis thaliana, 71.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:789823-794304:+ | gene-YDR180W_AKU4011 | rna-NM_001180488.3_AKU4011 | cds-NP_010466.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:331495-335976:- | gene-YDR180W_BG1 | rna-NM_001180488.3_BG1 | cds-NP_010466.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:822245-826726:+ | gene-YDR180W_Bruggeman | rna-NM_001180488.3_Bruggeman | cds-NP_010466.3_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:809492-813973:+ | gene-YDR180W_CAT1 | rna-NM_001180488.3_CAT1 | cds-NP_010466.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:780190-784671:+ | gene-YDR180W_CBS1585 | rna-NM_001180488.3_CBS1585 | cds-NP_010466.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:809174-813655:+ | gene-YDR180W_CBS436 | rna-NM_001180488.3_CBS436 | cds-NP_010466.3_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:776995-781476:+ | gene-YDR180W_CBS6412 | rna-NM_001180488.3_CBS6412 | cds-NP_010466.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:807538-812019:+ | gene-YDR180W_CBS6413 | rna-NM_001180488.3_CBS6413 | cds-NP_010466.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:820102-824583:+ | gene-YDR180W_CENPK1137D | rna-NM_001180488.3_CENPK1137D | cds-NP_010466.3_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:790592-795073:+ | gene-YDR180W_EthanolRed | rna-NM_001180488.3_EthanolRed | cds-NP_010466.3_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:798804-803285:+ | gene-YDR180W_FaliES1 | rna-NM_001180488.3_FaliES1 | cds-NP_010466.3_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000068.1:46078-50559:- | gene-YDR180W_JAY291 | rna-NM_001180488.3_JAY291 | cds-NP_010466.3_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:807891-812372:+ | gene-YDR180W_MUCL30387 | rna-NM_001180488.3_MUCL30387 | cds-NP_010466.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:796133-800614:+ | gene-YDR180W_MUCL30388 | rna-NM_001180488.3_MUCL30388 | cds-NP_010466.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:781637-786118:+ | gene-YDR180W_MUCL39482 | rna-NM_001180488.3_MUCL39482 | cds-NP_010466.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:720334-724815:+ | gene-YDR180W_MUCL42920 | rna-NM_001180488.3_MUCL42920 | cds-NP_010466.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:821218-825699:+ | gene-YDR180W_NCIM3186 | rna-NM_001180488.3_NCIM3186 | cds-NP_010466.3_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:784770-789251:+ | gene-YDR180W_NCYC1407 | rna-NM_001180488.3_NCYC1407 | cds-NP_010466.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:801496-805977:+ | gene-YDR180W_PE2H3 | rna-NM_001180488.3_PE2H3 | cds-NP_010466.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:800801-805282:+ | gene-YDR180W_PE2H4 | rna-NM_001180488.3_PE2H4 | cds-NP_010466.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:821295-825776:+ | gene-YDR180W_S288C | rna-NM_001180488.3_S288C | cds-NP_010466.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:167006-171487:+ | gene-YDR180W_SA1 | rna-NM_001180488.3_SA1 | cds-NP_010466.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:796959-801440:+ | gene-YDR180W_ThermosaccDry | rna-NM_001180488.3_ThermosaccDry | cds-NP_010466.3_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:812187-816668:+ | gene-YDR180W_VR1 | rna-NM_001180488.3_VR1 | cds-NP_010466.3_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:59669-64150:+ | gene-YDR180W_ZTW1 | rna-NM_001180488.3_ZTW1 | cds-NP_010466.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:802122-806603:+ | gene-YDR180W_Sparadoxus | rna-NM_001180488.3_Sparadoxus | cds-NP_010466.3_Sparadoxus | 87.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |