Gene name: SAN1
Reference locus (S288C): YDR143C
Gene biotype: protein_coding
Description: Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins
Top 10 interactors (score): UBR1 (0.985); SSM4 (0.969); SPT16 (0.927); SIR4 (0.92); CDC13 (0.877); HUL5 (0.859); UBR2 (0.845); YDJ1 (0.833); RKR1 (0.819); SSE1 (0.814); HRD1 (0.81); UFD2 (0.801); SSA1 (0.792); SIS1 (0.79); CDC48 (0.766); UFD1 (0.754); YOS9 (0.752); TUL1 (0.74); RSP5 (0.737); UBC1 (0.736)
Homologues (species, bitscore): CG13605 (Drosophila melanogaster, 51.6); AT2G03000 (Arabidopsis thaliana, 56.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:712977-714809:- | gene-YDR143C_AKU4011 | rna-NM_001180450.3_AKU4011 | cds-NP_010427.3_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:410023-411864:+ | gene-YDR143C_BG1 | rna-NM_001180450.3_BG1 | cds-NP_010427.3_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:745033-746865:- | gene-YDR143C_Bruggeman | rna-NM_001180450.3_Bruggeman | cds-NP_010427.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:733005-734837:- | gene-YDR143C_CAT1 | rna-NM_001180450.3_CAT1 | cds-NP_010427.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:704015-705847:- | gene-YDR143C_CBS1585 | rna-NM_001180450.3_CBS1585 | cds-NP_010427.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:729916-731757:- | gene-YDR143C_CBS436 | rna-NM_001180450.3_CBS436 | cds-NP_010427.3_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:700367-702199:- | gene-YDR143C_CBS6412 | rna-NM_001180450.3_CBS6412 | cds-NP_010427.3_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:729342-731174:- | gene-YDR143C_CBS6413 | rna-NM_001180450.3_CBS6413 | cds-NP_010427.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:734480-736312:- | gene-YDR143C_CENPK1137D | rna-NM_001180450.3_CENPK1137D | cds-NP_010427.3_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:714739-716571:- | gene-YDR143C_EthanolRed | rna-NM_001180450.3_EthanolRed | cds-NP_010427.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:721533-723365:- | gene-YDR143C_FaliES1 | rna-NM_001180450.3_FaliES1 | cds-NP_010427.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000002.1:73673-75505:- | gene-YDR143C_JAY291 | rna-NM_001180450.3_JAY291 | cds-NP_010427.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:730957-732789:- | gene-YDR143C_MUCL30387 | rna-NM_001180450.3_MUCL30387 | cds-NP_010427.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:719976-721808:- | gene-YDR143C_MUCL30388 | rna-NM_001180450.3_MUCL30388 | cds-NP_010427.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:705357-707189:- | gene-YDR143C_MUCL39482 | rna-NM_001180450.3_MUCL39482 | cds-NP_010427.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:643314-645146:- | gene-YDR143C_MUCL42920 | rna-NM_001180450.3_MUCL42920 | cds-NP_010427.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:741965-743797:- | gene-YDR143C_NCIM3186 | rna-NM_001180450.3_NCIM3186 | cds-NP_010427.3_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:704759-706591:- | gene-YDR143C_NCYC1407 | rna-NM_001180450.3_NCYC1407 | cds-NP_010427.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:724097-725929:- | gene-YDR143C_PE2H3 | rna-NM_001180450.3_PE2H3 | cds-NP_010427.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:723402-725234:- | gene-YDR143C_PE2H4 | rna-NM_001180450.3_PE2H4 | cds-NP_010427.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:742042-743874:- | gene-YDR143C_S288C | rna-NM_001180450.3_S288C | cds-NP_010427.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:90713-92545:- | gene-YDR143C_SA1 | rna-NM_001180450.3_SA1 | cds-NP_010427.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:721055-722887:- | gene-YDR143C_ThermosaccDry | rna-NM_001180450.3_ThermosaccDry | cds-NP_010427.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:734415-736256:- | gene-YDR143C_VR1 | rna-NM_001180450.3_VR1 | cds-NP_010427.3_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:718638-720470:- | gene-YDR143C_ZTW1 | rna-NM_001180450.3_ZTW1 | cds-NP_010427.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:723216-725021:- | gene-YDR143C_Sparadoxus | rna-NM_001180450.3_Sparadoxus | cds-NP_010427.3_Sparadoxus | 85.9 | 98.2 | Verified | 1 | 1 | 1 | False | True | False | False | False |