Gene name: SAM4
Reference locus (S288C): YPL273W
Gene biotype: protein_coding
Description: Homocysteine S-methyltransferase 2; S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication
Top 10 interactors (score): SAM1 (0.977); SAM2 (0.97); STR2 (0.961); CYS4 (0.959); SAH1 (0.956); ARO8 (0.942); THR1 (0.92); IRC7 (0.92); YLL058W (0.92); STR3 (0.915); YML082W (0.915); MET6 (0.905); YKL069W (0.901); ILV1 (0.881); YMR321C (0.874); MHT1 (0.857); CYS3 (0.853); CHA1 (0.843); MET17 (0.84); MCY1 (0.839)
Homologues (species, bitscore): BHMT2 (Homo sapiens, 53.9); Mtr (Mus musculus, 53.9); zgc:172121 (Danio rerio, 99.0); MGC75760 (Xenopus tropicalis, 89.0); CG10621 (Drosophila melanogaster, 97.4); T13G4.4 (Caenorhabditis elegans, 79.7); HMT-1 (Arabidopsis thaliana, 114.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:9143-10120:+ | gene-YPL273W_AKU4011 | rna-NM_001184087.1_AKU4011 | cds-NP_015050.1_AKU4011 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000197.1:2720-3697:- | gene-YPL273W_BG1 | rna-NM_001184087.1_BG1 | cds-NP_015050.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:24329-25306:+ | gene-YPL273W_Bruggeman | rna-NM_001184087.1_Bruggeman | cds-NP_015050.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:24349-25326:+ | gene-YPL273W_CAT1 | rna-NM_001184087.1_CAT1 | cds-NP_015050.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:12896-13871:+ | gene-YPL273W_CBS1585 | rna-NM_001184087.1_CBS1585 | cds-NP_015050.1_CBS1585 | 97.1 | 99.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:21243-22220:+ | gene-YPL273W_CBS436 | rna-NM_001184087.1_CBS436 | cds-NP_015050.1_CBS436 | 98.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:18357-18981:+ | gene-YPL273W_CBS6412 | rna-NM_001184087.1_CBS6412 | cds-NP_015050.1_CBS6412 | 63.2 | 63.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:9003-9980:+ | gene-YPL273W_CBS6413 | rna-NM_001184087.1_CBS6413 | cds-NP_015050.1_CBS6413 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:25033-26010:+ | gene-YPL273W_CENPK1137D | rna-NM_001184087.1_CENPK1137D | cds-NP_015050.1_CENPK1137D | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:8614-9399:+ | gene-YPL273W_EthanolRed | rna-NM_001184087.1_EthanolRed | cds-NP_015050.1_EthanolRed | 79.1 | 80.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:8613-9591:+ | gene-YPL273W_FaliES1 | rna-NM_001184087.1_FaliES1 | cds-NP_015050.1_FaliES1 | 92.4 | 98.1 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000222.1:6-983:- | gene-YPL273W_JAY291 | rna-NM_001184087.1_JAY291 | cds-NP_015050.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:25715-26692:+ | gene-YPL273W_MUCL30387 | rna-NM_001184087.1_MUCL30387 | cds-NP_015050.1_MUCL30387 | 98.9 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:23595-24564:+ | gene-YPL273W_MUCL30388 | rna-NM_001184087.1_MUCL30388 | cds-NP_015050.1_MUCL30388 | 97.9 | 99.1 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:6026-7001:+ | gene-YPL273W_MUCL39482 | rna-NM_001184087.1_MUCL39482 | cds-NP_015050.1_MUCL39482 | 97.1 | 99.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:18002-18979:+ | gene-YPL273W_MUCL42920 | rna-NM_001184087.1_MUCL42920 | cds-NP_015050.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:25070-26047:+ | gene-YPL273W_NCIM3186 | rna-NM_001184087.1_NCIM3186 | cds-NP_015050.1_NCIM3186 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:12472-13447:+ | gene-YPL273W_NCYC1407 | rna-NM_001184087.1_NCYC1407 | cds-NP_015050.1_NCYC1407 | 97.1 | 99.6 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:16326-17303:+ | gene-YPL273W_PE2H3 | rna-NM_001184087.1_PE2H3 | cds-NP_015050.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:901243-902220:- | gene-YPL273W_PE2H4 | rna-NM_001184087.1_PE2H4 | cds-NP_015050.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:25087-26064:+ | gene-YPL273W_S288C | rna-NM_001184087.1_S288C | cds-NP_015050.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000036.1:95147-96124:- | gene-YPL273W_SA1 | rna-NM_001184087.1_SA1 | cds-NP_015050.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:8614-9592:+ | gene-YPL273W_ThermosaccDry | rna-NM_001184087.1_ThermosaccDry | cds-NP_015050.1_ThermosaccDry | 92.4 | 98.1 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:904985-905962:- | gene-YPL273W_VR1 | rna-NM_001184087.1_VR1 | cds-NP_015050.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:14892-15869:+ | gene-YPL273W_ZTW1 | rna-NM_001184087.1_ZTW1 | cds-NP_015050.1_ZTW1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:910414-911391:- | gene-YPL273W_Sparadoxus | rna-NM_001184087.1_Sparadoxus | cds-NP_015050.1_Sparadoxus | 90.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |