Gene name: SAK1
Reference locus (S288C): YER129W
Gene biotype: protein_coding
Description: Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal groth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family
Top 10 interactors (score): SNF4 (0.995); SNF1 (0.991); ELM1 (0.987); GAL83 (0.978); SIP1 (0.971); TOS3 (0.964); SIP2 (0.947); ATG1 (0.832); GLC7 (0.816); MIG1 (0.804); CMD1 (0.756); REG1 (0.739); MIH1 (0.735); IKS1 (0.693); CMK1 (0.686); CMK2 (0.681); BMH1 (0.656); SIP5 (0.652); NNK1 (0.644); BMH2 (0.642)
Homologues (species, bitscore): CAMKK1 (Homo sapiens, 190.7); Camkk1 (Mus musculus, 192.6); zgc:194737 (Danio rerio, 197.2); camkk1 (Xenopus tropicalis, 203.8); CG17698 (Drosophila melanogaster, 171.4); ckk-1 (Caenorhabditis elegans, 183.3); GRIK2 (Arabidopsis thaliana, 180.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:411157-414585:+ | gene-YER129W_AKU4011 | rna-NM_001179019.3_AKU4011 | cds-NP_011055.3_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:11069-14497:- | gene-YER129W_BG1 | rna-NM_001179019.3_BG1 | cds-NP_011055.3_BG1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:421623-425051:+ | gene-YER129W_Bruggeman | rna-NM_001179019.3_Bruggeman | cds-NP_011055.3_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:416864-420292:+ | gene-YER129W_CAT1 | rna-NM_001179019.3_CAT1 | cds-NP_011055.3_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:410552-413980:+ | gene-YER129W_CBS1585 | rna-NM_001179019.3_CBS1585 | cds-NP_011055.3_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:413257-416685:+ | gene-YER129W_CBS436 | rna-NM_001179019.3_CBS436 | cds-NP_011055.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:409630-413058:+ | gene-YER129W_CBS6412 | rna-NM_001179019.3_CBS6412 | cds-NP_011055.3_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:416473-419901:+ | gene-YER129W_CBS6413 | rna-NM_001179019.3_CBS6413 | cds-NP_011055.3_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:415045-418473:+ | gene-YER129W_CENPK1137D | rna-NM_001179019.3_CENPK1137D | cds-NP_011055.3_CENPK1137D | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:411001-414429:+ | gene-YER129W_EthanolRed | rna-NM_001179019.3_EthanolRed | cds-NP_011055.3_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:411482-414910:+ | gene-YER129W_FaliES1 | rna-NM_001179019.3_FaliES1 | cds-NP_011055.3_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000028.1:19704-23132:+ | gene-YER129W_JAY291 | rna-NM_001179019.3_JAY291 | cds-NP_011055.3_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:418572-422000:+ | gene-YER129W_MUCL30387 | rna-NM_001179019.3_MUCL30387 | cds-NP_011055.3_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:413518-416946:+ | gene-YER129W_MUCL30388 | rna-NM_001179019.3_MUCL30388 | cds-NP_011055.3_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:409577-413005:+ | gene-YER129W_MUCL39482 | rna-NM_001179019.3_MUCL39482 | cds-NP_011055.3_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:418064-421492:+ | gene-YER129W_MUCL42920 | rna-NM_001179019.3_MUCL42920 | cds-NP_011055.3_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:417280-420708:+ | gene-YER129W_NCIM3186 | rna-NM_001179019.3_NCIM3186 | cds-NP_011055.3_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:415110-418538:+ | gene-YER129W_NCYC1407 | rna-NM_001179019.3_NCYC1407 | cds-NP_011055.3_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:425655-429083:+ | gene-YER129W_PE2H3 | rna-NM_001179019.3_PE2H3 | cds-NP_011055.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:415596-419024:+ | gene-YER129W_PE2H4 | rna-NM_001179019.3_PE2H4 | cds-NP_011055.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:417281-420709:+ | gene-YER129W_S288C | rna-NM_001179019.3_S288C | cds-NP_011055.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:126881-130309:+ | gene-YER129W_SA1 | rna-NM_001179019.3_SA1 | cds-NP_011055.3_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:412280-415708:+ | gene-YER129W_ThermosaccDry | rna-NM_001179019.3_ThermosaccDry | cds-NP_011055.3_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:413332-416760:+ | gene-YER129W_VR1 | rna-NM_001179019.3_VR1 | cds-NP_011055.3_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:409409-412837:+ | gene-YER129W_ZTW1 | rna-NM_001179019.3_ZTW1 | cds-NP_011055.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:413221-416655:+ | gene-YER129W_Sparadoxus | rna-NM_001179019.3_Sparadoxus | cds-NP_011055.3_Sparadoxus | 87.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |