Gene name: SAE2
Reference locus (S288C): YGL175C
Gene biotype: protein_coding
Description: DNA endonuclease SAE2; Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the MRX complex; function requires sumoylation and phosphorylation; exists as inactive oligomers that are transiently released into smaller active units by phosphorylation; DNA damage triggers Sae2p removal, so active Sae2p is present only transiently; sequence and functional similarity with human CtIP/RBBP8; Belongs to the COM1/SAE2/CtIP family
Top 10 interactors (score): SGS1 (0.992); EXO1 (0.991); SPO11 (0.983); MRE11 (0.983); MEC1 (0.975); TEL1 (0.974); XRS2 (0.957); DNA2 (0.957); RAD9 (0.942); RAD50 (0.94); YKU70 (0.938); RFA1 (0.891); RAD53 (0.887); MMS4 (0.881); RAD27 (0.87); MND1 (0.851); HOP2 (0.85); CDC28 (0.844); RMI1 (0.841); RED1 (0.836)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:175857-176894:- | gene-YGL175C_AKU4011 | rna-NM_001181040.1_AKU4011 | cds-NP_011340.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:233468-234505:+ | gene-YGL175C_BG1 | rna-NM_001181040.1_BG1 | cds-NP_011340.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:178050-179087:- | gene-YGL175C_Bruggeman | rna-NM_001181040.1_Bruggeman | cds-NP_011340.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:173920-174957:- | gene-YGL175C_CAT1 | rna-NM_001181040.1_CAT1 | cds-NP_011340.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:178996-180033:- | gene-YGL175C_CBS1585 | rna-NM_001181040.1_CBS1585 | cds-NP_011340.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:173910-174947:- | gene-YGL175C_CBS436 | rna-NM_001181040.1_CBS436 | cds-NP_011340.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:165459-166496:- | gene-YGL175C_CBS6412 | rna-NM_001181040.1_CBS6412 | cds-NP_011340.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:173308-174345:- | gene-YGL175C_CBS6413 | rna-NM_001181040.1_CBS6413 | cds-NP_011340.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:173476-174513:- | gene-YGL175C_CENPK1137D | rna-NM_001181040.1_CENPK1137D | cds-NP_011340.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:165664-166701:- | gene-YGL175C_EthanolRed | rna-NM_001181040.1_EthanolRed | cds-NP_011340.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:166910-167947:- | gene-YGL175C_FaliES1 | rna-NM_001181040.1_FaliES1 | cds-NP_011340.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000090.1:17144-18181:- | gene-YGL175C_JAY291 | rna-NM_001181040.1_JAY291 | cds-NP_011340.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:175301-176338:- | gene-YGL175C_MUCL30387 | rna-NM_001181040.1_MUCL30387 | cds-NP_011340.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:178388-179425:- | gene-YGL175C_MUCL30388 | rna-NM_001181040.1_MUCL30388 | cds-NP_011340.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:176020-177057:- | gene-YGL175C_MUCL39482 | rna-NM_001181040.1_MUCL39482 | cds-NP_011340.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:178605-179642:- | gene-YGL175C_MUCL42920 | rna-NM_001181040.1_MUCL42920 | cds-NP_011340.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:173285-174322:- | gene-YGL175C_NCIM3186 | rna-NM_001181040.1_NCIM3186 | cds-NP_011340.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:167484-168521:- | gene-YGL175C_NCYC1407 | rna-NM_001181040.1_NCYC1407 | cds-NP_011340.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:169444-170481:- | gene-YGL175C_PE2H3 | rna-NM_001181040.1_PE2H3 | cds-NP_011340.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:168992-170029:- | gene-YGL175C_PE2H4 | rna-NM_001181040.1_PE2H4 | cds-NP_011340.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:173285-174322:- | gene-YGL175C_S288C | rna-NM_001181040.1_S288C | cds-NP_011340.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000067.1:33102-34139:- | gene-YGL175C_SA1 | rna-NM_001181040.1_SA1 | cds-NP_011340.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:167139-168176:- | gene-YGL175C_ThermosaccDry | rna-NM_001181040.1_ThermosaccDry | cds-NP_011340.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:174346-175383:- | gene-YGL175C_VR1 | rna-NM_001181040.1_VR1 | cds-NP_011340.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:165589-166626:- | gene-YGL175C_ZTW1 | rna-NM_001181040.1_ZTW1 | cds-NP_011340.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:172457-173494:- | gene-YGL175C_Sparadoxus | rna-NM_001181040.1_Sparadoxus | cds-NP_011340.1_Sparadoxus | 89.1 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |