Gene name: SAC7
Reference locus (S288C): YDR389W
Gene biotype: protein_coding
Description: GTPase-activating protein SAC7; GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication
Top 10 interactors (score): RHO1 (0.998); RHO2 (0.961); RHO4 (0.958); CDC42 (0.955); RHO3 (0.943); RHO5 (0.943); LRG1 (0.936); GEM1 (0.932); PKC1 (0.872); TOR2 (0.867); ROM2 (0.863); RDI1 (0.847); BEM2 (0.826); TUS1 (0.823); SLM1 (0.799); SMC2 (0.775); ROM1 (0.716); BIG1 (0.648); MPS1 (0.644); RGD2 (0.639)
Homologues (species, bitscore): ARHGAP6 (Homo sapiens, 70.9); Arhgap6 (Mus musculus, 71.2); ARHGAP36 (Danio rerio, 72.0); arhgap25 (Xenopus tropicalis, 69.7); RhoGAP102A (Drosophila melanogaster, 67.8); rga-6 (Caenorhabditis elegans, 61.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1192679-1194643:+ | gene-YDR389W_AKU4011 | rna-NM_001180697.1_AKU4011 | cds-NP_010677.1_AKU4011 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:71163-73127:+ | gene-YDR389W_BG1 | rna-NM_001180697.1_BG1 | cds-NP_010677.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1223563-1225527:+ | gene-YDR389W_Bruggeman | rna-NM_001180697.1_Bruggeman | cds-NP_010677.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1202119-1204083:+ | gene-YDR389W_CAT1 | rna-NM_001180697.1_CAT1 | cds-NP_010677.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1187600-1189564:+ | gene-YDR389W_CBS1585 | rna-NM_001180697.1_CBS1585 | cds-NP_010677.1_CBS1585 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1206466-1208430:+ | gene-YDR389W_CBS436 | rna-NM_001180697.1_CBS436 | cds-NP_010677.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1183653-1185617:+ | gene-YDR389W_CBS6412 | rna-NM_001180697.1_CBS6412 | cds-NP_010677.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1205508-1207472:+ | gene-YDR389W_CBS6413 | rna-NM_001180697.1_CBS6413 | cds-NP_010677.1_CBS6413 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1251198-1253162:+ | gene-YDR389W_CENPK1137D | rna-NM_001180697.1_CENPK1137D | cds-NP_010677.1_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1197084-1199048:+ | gene-YDR389W_EthanolRed | rna-NM_001180697.1_EthanolRed | cds-NP_010677.1_EthanolRed | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1200394-1202358:+ | gene-YDR389W_FaliES1 | rna-NM_001180697.1_FaliES1 | cds-NP_010677.1_FaliES1 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000181.1:53178-55142:- | gene-YDR389W_JAY291 | rna-NM_001180697.1_JAY291 | cds-NP_010677.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1207125-1209089:+ | gene-YDR389W_MUCL30387 | rna-NM_001180697.1_MUCL30387 | cds-NP_010677.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1189238-1191202:+ | gene-YDR389W_MUCL30388 | rna-NM_001180697.1_MUCL30388 | cds-NP_010677.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1178928-1180892:+ | gene-YDR389W_MUCL39482 | rna-NM_001180697.1_MUCL39482 | cds-NP_010677.1_MUCL39482 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1121365-1123329:+ | gene-YDR389W_MUCL42920 | rna-NM_001180697.1_MUCL42920 | cds-NP_010677.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1252460-1254424:+ | gene-YDR389W_NCIM3186 | rna-NM_001180697.1_NCIM3186 | cds-NP_010677.1_NCIM3186 | 95.1 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1192899-1194863:+ | gene-YDR389W_NCYC1407 | rna-NM_001180697.1_NCYC1407 | cds-NP_010677.1_NCYC1407 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1203026-1204990:+ | gene-YDR389W_PE2H3 | rna-NM_001180697.1_PE2H3 | cds-NP_010677.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1208599-1210563:+ | gene-YDR389W_PE2H4 | rna-NM_001180697.1_PE2H4 | cds-NP_010677.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1252537-1254501:+ | gene-YDR389W_S288C | rna-NM_001180697.1_S288C | cds-NP_010677.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000071.1:53291-55255:- | gene-YDR389W_SA1 | rna-NM_001180697.1_SA1 | cds-NP_010677.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1204656-1206620:+ | gene-YDR389W_ThermosaccDry | rna-NM_001180697.1_ThermosaccDry | cds-NP_010677.1_ThermosaccDry | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1219838-1221802:+ | gene-YDR389W_VR1 | rna-NM_001180697.1_VR1 | cds-NP_010677.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:247466-249430:+ | gene-YDR389W_ZTW1 | rna-NM_001180697.1_ZTW1 | cds-NP_010677.1_ZTW1 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1199214-1201178:+ | gene-YDR389W_Sparadoxus | rna-NM_001180697.1_Sparadoxus | cds-NP_010677.1_Sparadoxus | 91.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |