Gene name: SAC6
Reference locus (S288C): YDR129C
Gene biotype: protein_coding
Description: Plastin-1; Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant
Top 10 interactors (score): ACT1 (0.999); ARP2 (0.996); CAP2 (0.994); COF1 (0.994); ABP1 (0.992); SCP1 (0.991); CRN1 (0.988); TPM1 (0.988); TPM2 (0.984); LAS17 (0.981); SLA2 (0.977); PFY1 (0.971); RVS167 (0.969); SRV2 (0.969); ABP140 (0.953); BNI1 (0.945); TWF1 (0.944); MYO5 (0.929); ARP3 (0.929); END3 (0.928)
Homologues (species, bitscore): PLS3 (Homo sapiens, 434.1); Pls3 (Mus musculus, 431.8); pls3 (Danio rerio, 407.9); pls3 (Xenopus tropicalis, 425.6); Fim (Drosophila melanogaster, 433.7); plst-1 (Caenorhabditis elegans, 278.9); FIM5 (Arabidopsis thaliana, 438.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:684276-686315:- | gene-YDR129C_AKU4011 | rna-NM_001180437.3_AKU4011 | cds-NP_010414.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:438553-440592:+ | gene-YDR129C_BG1 | rna-NM_001180437.3_BG1 | cds-NP_010414.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:716335-718374:- | gene-YDR129C_Bruggeman | rna-NM_001180437.3_Bruggeman | cds-NP_010414.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:703337-705376:- | gene-YDR129C_CAT1 | rna-NM_001180437.3_CAT1 | cds-NP_010414.3_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:675314-677353:- | gene-YDR129C_CBS1585 | rna-NM_001180437.3_CBS1585 | cds-NP_010414.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:701203-703242:- | gene-YDR129C_CBS436 | rna-NM_001180437.3_CBS436 | cds-NP_010414.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:671666-673705:- | gene-YDR129C_CBS6412 | rna-NM_001180437.3_CBS6412 | cds-NP_010414.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:700642-702681:- | gene-YDR129C_CBS6413 | rna-NM_001180437.3_CBS6413 | cds-NP_010414.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:705781-707820:- | gene-YDR129C_CENPK1137D | rna-NM_001180437.3_CENPK1137D | cds-NP_010414.3_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:686039-688078:- | gene-YDR129C_EthanolRed | rna-NM_001180437.3_EthanolRed | cds-NP_010414.3_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:692833-694872:- | gene-YDR129C_FaliES1 | rna-NM_001180437.3_FaliES1 | cds-NP_010414.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000002.1:44962-47001:- | gene-YDR129C_JAY291 | rna-NM_001180437.3_JAY291 | cds-NP_010414.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:702259-704298:- | gene-YDR129C_MUCL30387 | rna-NM_001180437.3_MUCL30387 | cds-NP_010414.3_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:691278-693317:- | gene-YDR129C_MUCL30388 | rna-NM_001180437.3_MUCL30388 | cds-NP_010414.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:676657-678696:- | gene-YDR129C_MUCL39482 | rna-NM_001180437.3_MUCL39482 | cds-NP_010414.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:614605-616644:- | gene-YDR129C_MUCL42920 | rna-NM_001180437.3_MUCL42920 | cds-NP_010414.3_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:713263-715302:- | gene-YDR129C_NCIM3186 | rna-NM_001180437.3_NCIM3186 | cds-NP_010414.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:676060-678099:- | gene-YDR129C_NCYC1407 | rna-NM_001180437.3_NCYC1407 | cds-NP_010414.3_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:695391-697430:- | gene-YDR129C_PE2H3 | rna-NM_001180437.3_PE2H3 | cds-NP_010414.3_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:694696-696735:- | gene-YDR129C_PE2H4 | rna-NM_001180437.3_PE2H4 | cds-NP_010414.3_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:713340-715379:- | gene-YDR129C_S288C | rna-NM_001180437.3_S288C | cds-NP_010414.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:62007-64046:- | gene-YDR129C_SA1 | rna-NM_001180437.3_SA1 | cds-NP_010414.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:692355-694394:- | gene-YDR129C_ThermosaccDry | rna-NM_001180437.3_ThermosaccDry | cds-NP_010414.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:705705-707744:- | gene-YDR129C_VR1 | rna-NM_001180437.3_VR1 | cds-NP_010414.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:689941-691980:- | gene-YDR129C_ZTW1 | rna-NM_001180437.3_ZTW1 | cds-NP_010414.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:694422-696460:- | gene-YDR129C_Sparadoxus | rna-NM_001180437.3_Sparadoxus | cds-NP_010414.3_Sparadoxus | 90.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |