Gene name: RTC2
Reference locus (S288C): YBR147W
Gene biotype: protein_coding
Description: Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication; Belongs to the laat-1 family
Top 10 interactors (score): ERS1 (0.84); PKP2 (0.785); YMR099C (0.746); YLR407W (0.676); ARG4 (0.633); AVT1 (0.621); ALP1 (0.611); ADH5 (0.609); ANY1 (0.604); TMT1 (0.593); MRT4 (0.573); YDR090C (0.571); YBR144C (0.568); SNA2 (0.568); ERC1 (0.565); VBA5 (0.563); ORT1 (0.552); ARG5,6 (0.535); YGR283C (0.499); RUP1 (0.489)
Homologues (species, bitscore): PQLC2 (Homo sapiens, 89.0); Pqlc2 (Mus musculus, 84.7); pqlc2 (Danio rerio, 104.8); C3orf55 (Xenopus tropicalis, 93.6); Y43H11AL.2 (Caenorhabditis elegans, 114.0); AT4G20100 (Arabidopsis thaliana, 121.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:519467-520390:+ | gene-YBR147W_AKU4011 | rna-NM_001178495.1_AKU4011 | cds-NP_009705.1_AKU4011 | 95.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:510032-510955:+ | gene-YBR147W_BG1 | rna-NM_001178495.1_BG1 | cds-NP_009705.1_BG1 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:522258-523181:+ | gene-YBR147W_Bruggeman | rna-NM_001178495.1_Bruggeman | cds-NP_009705.1_Bruggeman | 95.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:416605-417528:+ | gene-YBR147W_CAT1 | rna-NM_001178495.1_CAT1 | cds-NP_009705.1_CAT1 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:511246-512169:+ | gene-YBR147W_CBS1585 | rna-NM_001178495.1_CBS1585 | cds-NP_009705.1_CBS1585 | 95.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:519343-520266:+ | gene-YBR147W_CBS436 | rna-NM_001178495.1_CBS436 | cds-NP_009705.1_CBS436 | 95.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:609112-610035:+ | gene-YBR147W_CBS6412 | rna-NM_001178495.1_CBS6412 | cds-NP_009705.1_CBS6412 | 95.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:516881-517804:+ | gene-YBR147W_CBS6413 | rna-NM_001178495.1_CBS6413 | cds-NP_009705.1_CBS6413 | 95.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:530344-531234:+ | gene-YBR147W_CENPK1137D | rna-NM_001178495.1_CENPK1137D | cds-NP_009705.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:645487-646410:+ | gene-YBR147W_EthanolRed | rna-NM_001178495.1_EthanolRed | cds-NP_009705.1_EthanolRed | 95.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:535499-536422:+ | gene-YBR147W_FaliES1 | rna-NM_001178495.1_FaliES1 | cds-NP_009705.1_FaliES1 | 95.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000444.1:58943-59866:+ | gene-YBR147W_JAY291 | rna-NM_001178495.1_JAY291 | cds-NP_009705.1_JAY291 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:524128-525051:+ | gene-YBR147W_MUCL30387 | rna-NM_001178495.1_MUCL30387 | cds-NP_009705.1_MUCL30387 | 95.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:523420-524343:+ | gene-YBR147W_MUCL30388 | rna-NM_001178495.1_MUCL30388 | cds-NP_009705.1_MUCL30388 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:509633-510556:+ | gene-YBR147W_MUCL39482 | rna-NM_001178495.1_MUCL39482 | cds-NP_009705.1_MUCL39482 | 95.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:519528-520451:+ | gene-YBR147W_MUCL42920 | rna-NM_001178495.1_MUCL42920 | cds-NP_009705.1_MUCL42920 | 95.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:536372-537262:+ | gene-YBR147W_NCIM3186 | rna-NM_001178495.1_NCIM3186 | cds-NP_009705.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:512174-513097:+ | gene-YBR147W_NCYC1407 | rna-NM_001178495.1_NCYC1407 | cds-NP_009705.1_NCYC1407 | 95.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:524790-525713:+ | gene-YBR147W_PE2H3 | rna-NM_001178495.1_PE2H3 | cds-NP_009705.1_PE2H3 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:522466-523389:+ | gene-YBR147W_PE2H4 | rna-NM_001178495.1_PE2H4 | cds-NP_009705.1_PE2H4 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:536575-537465:+ | gene-YBR147W_S288C | rna-NM_001178495.1_S288C | cds-NP_009705.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000032.1:57758-58681:+ | gene-YBR147W_SA1 | rna-NM_001178495.1_SA1 | cds-NP_009705.1_SA1 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:534512-535435:+ | gene-YBR147W_ThermosaccDry | rna-NM_001178495.1_ThermosaccDry | cds-NP_009705.1_ThermosaccDry | 95.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:516007-516930:+ | gene-YBR147W_VR1 | rna-NM_001178495.1_VR1 | cds-NP_009705.1_VR1 | 95.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:509659-510582:+ | gene-YBR147W_ZTW1 | rna-NM_001178495.1_ZTW1 | cds-NP_009705.1_ZTW1 | 95.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:546908-547834:+ | gene-YBR147W_Sparadoxus | rna-NM_001178495.1_Sparadoxus | cds-NP_009705.1_Sparadoxus | 87.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |