Gene name: RTC1
Reference locus (S288C): YOL138C
Gene biotype: protein_coding
Description: Restriction of telomere capping protein 1; Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; null suppresses cdc13-1
Top 10 interactors (score): NPR2 (0.999); SEH1 (0.999); SEC13 (0.999); IML1 (0.999); MTC5 (0.999); SEA4 (0.999); NPR3 (0.987); GTR1 (0.951); GTR2 (0.915); LST7 (0.894); RHB1 (0.809); KOG1 (0.776); MEH1 (0.745); SLM4 (0.745); LST4 (0.744); EGO2 (0.71); RRB1 (0.684); MAP2 (0.681); VAM6 (0.668); FAB1 (0.667)
Homologues (species, bitscore): WDR24 (Homo sapiens, 83.2); Wdr24 (Mus musculus, 82.8); wdr24 (Danio rerio, 90.5); wdr24 (Xenopus tropicalis, 84.7); CG7609 (Drosophila melanogaster, 85.5); Y32H12A.8 (Caenorhabditis elegans, 52.4); FY (Arabidopsis thaliana, 62.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:49986-54008:- | gene-YOL138C_AKU4011 | rna-NM_001183392.2_AKU4011 | cds-NP_014503.2_AKU4011 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000172.1:15604-19629:- | gene-YOL138C_BG1 | rna-NM_001183392.2_BG1 | cds-NP_014503.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:51263-55285:- | gene-YOL138C_Bruggeman | rna-NM_001183392.2_Bruggeman | cds-NP_014503.2_Bruggeman | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:50218-54243:- | gene-YOL138C_CAT1 | rna-NM_001183392.2_CAT1 | cds-NP_014503.2_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:44460-48482:- | gene-YOL138C_CBS1585 | rna-NM_001183392.2_CBS1585 | cds-NP_014503.2_CBS1585 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:50303-54331:- | gene-YOL138C_CBS436 | rna-NM_001183392.2_CBS436 | cds-NP_014503.2_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:44326-48348:- | gene-YOL138C_CBS6412 | rna-NM_001183392.2_CBS6412 | cds-NP_014503.2_CBS6412 | 99.3 | 99.9 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:50794-54816:- | gene-YOL138C_CBS6413 | rna-NM_001183392.2_CBS6413 | cds-NP_014503.2_CBS6413 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:61218-65246:- | gene-YOL138C_CENPK1137D | rna-NM_001183392.2_CENPK1137D | cds-NP_014503.2_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:48237-52259:- | gene-YOL138C_EthanolRed | rna-NM_001183392.2_EthanolRed | cds-NP_014503.2_EthanolRed | 99.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:50266-54288:- | gene-YOL138C_FaliES1 | rna-NM_001183392.2_FaliES1 | cds-NP_014503.2_FaliES1 | 99.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000329.1:28266-32294:+ | gene-YOL138C_JAY291 | rna-NM_001183392.2_JAY291 | cds-NP_014503.2_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:55903-59925:- | gene-YOL138C_MUCL30387 | rna-NM_001183392.2_MUCL30387 | cds-NP_014503.2_MUCL30387 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:58894-62919:- | gene-YOL138C_MUCL30388 | rna-NM_001183392.2_MUCL30388 | cds-NP_014503.2_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:52380-56417:- | gene-YOL138C_MUCL39482 | rna-NM_001183392.2_MUCL39482 | cds-NP_014503.2_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:68283-72305:- | gene-YOL138C_MUCL42920 | rna-NM_001183392.2_MUCL42920 | cds-NP_014503.2_MUCL42920 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:61214-65239:- | gene-YOL138C_NCIM3186 | rna-NM_001183392.2_NCIM3186 | cds-NP_014503.2_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:58436-62458:- | gene-YOL138C_NCYC1407 | rna-NM_001183392.2_NCYC1407 | cds-NP_014503.2_NCYC1407 | 99.3 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:36856-40884:- | gene-YOL138C_PE2H3 | rna-NM_001183392.2_PE2H3 | cds-NP_014503.2_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:53804-57832:- | gene-YOL138C_PE2H4 | rna-NM_001183392.2_PE2H4 | cds-NP_014503.2_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:61325-65350:- | gene-YOL138C_S288C | rna-NM_001183392.2_S288C | cds-NP_014503.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:34753-38781:- | gene-YOL138C_SA1 | rna-NM_001183392.2_SA1 | cds-NP_014503.2_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:49404-53426:- | gene-YOL138C_ThermosaccDry | rna-NM_001183392.2_ThermosaccDry | cds-NP_014503.2_ThermosaccDry | 99.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:50054-54082:- | gene-YOL138C_VR1 | rna-NM_001183392.2_VR1 | cds-NP_014503.2_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:49158-53180:- | gene-YOL138C_ZTW1 | rna-NM_001183392.2_ZTW1 | cds-NP_014503.2_ZTW1 | 99.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:51628-55647:- | gene-YOL138C_Sparadoxus | rna-NM_001183392.2_Sparadoxus | cds-NP_014503.2_Sparadoxus | 88.3 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |