Gene name: RSP5
Reference locus (S288C): YER125W
Gene biotype: protein_coding
Description: NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome; Belongs to the RSP5/NEDD4 family
Top 10 interactors (score): BUL1 (0.999); SNA3 (0.999); UBP2 (0.999); BSD2 (0.998); ROD1 (0.996); UBI4 (0.996); UBC4 (0.995); TEC1 (0.995); RPS31 (0.995); ROG3 (0.994); BUL2 (0.994); RPO21 (0.991); ALY2 (0.989); UBC5 (0.987); UBC1 (0.987); LDB19 (0.987); MGA2 (0.986); SPT23 (0.982); RUP1 (0.978); ALY1 (0.972)
Homologues (species, bitscore): NEDD4L (Homo sapiens, 578.9); Nedd4l (Mus musculus, 581.6); itch (Danio rerio, 580.5); nedd4l (Xenopus tropicalis, 583.2); Su(dx) (Drosophila melanogaster, 537.0); wwp-1 (Caenorhabditis elegans, 555.8); UPL1 (Arabidopsis thaliana, 343.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:404068-406497:+ | gene-YER125W_AKU4011 | rna-NM_001179015.3_AKU4011 | cds-NP_011051.3_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:19154-21583:- | gene-YER125W_BG1 | rna-NM_001179015.3_BG1 | cds-NP_011051.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:414535-416964:+ | gene-YER125W_Bruggeman | rna-NM_001179015.3_Bruggeman | cds-NP_011051.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:409775-412204:+ | gene-YER125W_CAT1 | rna-NM_001179015.3_CAT1 | cds-NP_011051.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:403463-405892:+ | gene-YER125W_CBS1585 | rna-NM_001179015.3_CBS1585 | cds-NP_011051.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:406166-408595:+ | gene-YER125W_CBS436 | rna-NM_001179015.3_CBS436 | cds-NP_011051.3_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:402541-404970:+ | gene-YER125W_CBS6412 | rna-NM_001179015.3_CBS6412 | cds-NP_011051.3_CBS6412 | 99.8 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:409384-411813:+ | gene-YER125W_CBS6413 | rna-NM_001179015.3_CBS6413 | cds-NP_011051.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:407956-410385:+ | gene-YER125W_CENPK1137D | rna-NM_001179015.3_CENPK1137D | cds-NP_011051.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:403912-406341:+ | gene-YER125W_EthanolRed | rna-NM_001179015.3_EthanolRed | cds-NP_011051.3_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:404393-406822:+ | gene-YER125W_FaliES1 | rna-NM_001179015.3_FaliES1 | cds-NP_011051.3_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000028.1:12613-15042:+ | gene-YER125W_JAY291 | rna-NM_001179015.3_JAY291 | cds-NP_011051.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:411484-413913:+ | gene-YER125W_MUCL30387 | rna-NM_001179015.3_MUCL30387 | cds-NP_011051.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:406430-408859:+ | gene-YER125W_MUCL30388 | rna-NM_001179015.3_MUCL30388 | cds-NP_011051.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:402488-404917:+ | gene-YER125W_MUCL39482 | rna-NM_001179015.3_MUCL39482 | cds-NP_011051.3_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:410975-413404:+ | gene-YER125W_MUCL42920 | rna-NM_001179015.3_MUCL42920 | cds-NP_011051.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:410188-412617:+ | gene-YER125W_NCIM3186 | rna-NM_001179015.3_NCIM3186 | cds-NP_011051.3_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:408020-410449:+ | gene-YER125W_NCYC1407 | rna-NM_001179015.3_NCYC1407 | cds-NP_011051.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:418562-420991:+ | gene-YER125W_PE2H3 | rna-NM_001179015.3_PE2H3 | cds-NP_011051.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:408503-410932:+ | gene-YER125W_PE2H4 | rna-NM_001179015.3_PE2H4 | cds-NP_011051.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:410189-412618:+ | gene-YER125W_S288C | rna-NM_001179015.3_S288C | cds-NP_011051.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:119795-122224:+ | gene-YER125W_SA1 | rna-NM_001179015.3_SA1 | cds-NP_011051.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:405191-407620:+ | gene-YER125W_ThermosaccDry | rna-NM_001179015.3_ThermosaccDry | cds-NP_011051.3_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:406246-408675:+ | gene-YER125W_VR1 | rna-NM_001179015.3_VR1 | cds-NP_011051.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:402322-404751:+ | gene-YER125W_ZTW1 | rna-NM_001179015.3_ZTW1 | cds-NP_011051.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:406217-408646:+ | gene-YER125W_Sparadoxus | rna-NM_001179015.3_Sparadoxus | cds-NP_011051.3_Sparadoxus | 93.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |