Gene name: RRT2
Reference locus (S288C): YBR246W
Gene biotype: protein_coding
Description: Diphthine methyltransferase; Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins
Top 10 interactors (score): DPH6 (0.999); DPH5 (0.998); DPH2 (0.994); DPH1 (0.991); KTI11 (0.974); RTT10 (0.944); JJJ3 (0.942); EFT2 (0.933); EFT1 (0.909); ELP2 (0.886); HMF1 (0.81); ATS1 (0.714); SNX3 (0.691); URA1 (0.66); KXD1 (0.568); MDJ1 (0.545); SNX4 (0.543); JEM1 (0.535); SNX41 (0.514); VAB2 (0.499)
Homologues (species, bitscore): DPH7 (Homo sapiens, 74.3); Dph7 (Mus musculus, 65.1); dph7 (Danio rerio, 62.4); DPH7 (Xenopus tropicalis, 60.8); CG3184 (Drosophila melanogaster, 107.1); AT5G63010 (Arabidopsis thaliana, 102.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:695902-697065:+ | gene-YBR246W_AKU4011 | rna-NM_001178594.1_AKU4011 | cds-NP_009805.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000066.1:66909-68072:+ | gene-YBR246W_BG1 | rna-NM_001178594.1_BG1 | cds-NP_009805.1_BG1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:697043-698206:+ | gene-YBR246W_Bruggeman | rna-NM_001178594.1_Bruggeman | cds-NP_009805.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:700532-701695:+ | gene-YBR246W_CAT1 | rna-NM_001178594.1_CAT1 | cds-NP_009805.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:687468-688631:+ | gene-YBR246W_CBS1585 | rna-NM_001178594.1_CBS1585 | cds-NP_009805.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:693887-695050:+ | gene-YBR246W_CBS436 | rna-NM_001178594.1_CBS436 | cds-NP_009805.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:782073-783236:+ | gene-YBR246W_CBS6412 | rna-NM_001178594.1_CBS6412 | cds-NP_009805.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:693517-694680:+ | gene-YBR246W_CBS6413 | rna-NM_001178594.1_CBS6413 | cds-NP_009805.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:705502-706665:+ | gene-YBR246W_CENPK1137D | rna-NM_001178594.1_CENPK1137D | cds-NP_009805.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:818925-820088:+ | gene-YBR246W_EthanolRed | rna-NM_001178594.1_EthanolRed | cds-NP_009805.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:712272-713435:+ | gene-YBR246W_FaliES1 | rna-NM_001178594.1_FaliES1 | cds-NP_009805.1_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000067.1:90629-91792:- | gene-YBR246W_JAY291 | rna-NM_001178594.1_JAY291 | cds-NP_009805.1_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:699086-700249:+ | gene-YBR246W_MUCL30387 | rna-NM_001178594.1_MUCL30387 | cds-NP_009805.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:716169-717332:+ | gene-YBR246W_MUCL30388 | rna-NM_001178594.1_MUCL30388 | cds-NP_009805.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:685775-686938:+ | gene-YBR246W_MUCL39482 | rna-NM_001178594.1_MUCL39482 | cds-NP_009805.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:695621-696784:+ | gene-YBR246W_MUCL42920 | rna-NM_001178594.1_MUCL42920 | cds-NP_009805.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:711388-712551:+ | gene-YBR246W_NCIM3186 | rna-NM_001178594.1_NCIM3186 | cds-NP_009805.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:687664-688827:+ | gene-YBR246W_NCYC1407 | rna-NM_001178594.1_NCYC1407 | cds-NP_009805.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:710770-711933:+ | gene-YBR246W_PE2H3 | rna-NM_001178594.1_PE2H3 | cds-NP_009805.1_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:708446-709609:+ | gene-YBR246W_PE2H4 | rna-NM_001178594.1_PE2H4 | cds-NP_009805.1_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:711591-712754:+ | gene-YBR246W_S288C | rna-NM_001178594.1_S288C | cds-NP_009805.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000019.1:66731-67894:+ | gene-YBR246W_SA1 | rna-NM_001178594.1_SA1 | cds-NP_009805.1_SA1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:711264-712427:+ | gene-YBR246W_ThermosaccDry | rna-NM_001178594.1_ThermosaccDry | cds-NP_009805.1_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:691480-692643:+ | gene-YBR246W_VR1 | rna-NM_001178594.1_VR1 | cds-NP_009805.1_VR1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:684123-685286:+ | gene-YBR246W_ZTW1 | rna-NM_001178594.1_ZTW1 | cds-NP_009805.1_ZTW1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:728097-729259:+ | gene-YBR246W_Sparadoxus | rna-NM_001178594.1_Sparadoxus | cds-NP_009805.1_Sparadoxus | 86.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |