Gene name: RRP8
Reference locus (S288C): YDR083W
Gene biotype: protein_coding
Description: 25S rRNA (adenine(645)-N(1))-methyltransferase; Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1; Belongs to the methyltransferase superfamily. RRP8 family
Top 10 interactors (score): RRP1 (0.999); NOP2 (0.999); NOP7 (0.997); RPF2 (0.997); DBP3 (0.997); PUF6 (0.997); NUG1 (0.996); DRS1 (0.996); EBP2 (0.995); SPB1 (0.995); NOP4 (0.994); EMG1 (0.994); NOB1 (0.994); IMP4 (0.993); NOC2 (0.992); NOP9 (0.992); SSF1 (0.99); KRI1 (0.988); BFR2 (0.988); RRP9 (0.987)
Homologues (species, bitscore): RRP8 (Homo sapiens, 164.5); Rrp8 (Mus musculus, 157.1); RRP8 (Danio rerio, 171.0); CG7137 (Drosophila melanogaster, 137.5); T07A9.8 (Caenorhabditis elegans, 144.4); AT5G40530 (Arabidopsis thaliana, 162.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:589631-590809:+ | gene-YDR083W_AKU4011 | rna-NM_001180391.3_AKU4011 | cds-NP_010368.5_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:534508-535686:- | gene-YDR083W_BG1 | rna-NM_001180391.3_BG1 | cds-NP_010368.5_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:621859-623037:+ | gene-YDR083W_Bruggeman | rna-NM_001180391.3_Bruggeman | cds-NP_010368.5_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:605501-606679:+ | gene-YDR083W_CAT1 | rna-NM_001180391.3_CAT1 | cds-NP_010368.5_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:580650-581828:+ | gene-YDR083W_CBS1585 | rna-NM_001180391.3_CBS1585 | cds-NP_010368.5_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:605668-606846:+ | gene-YDR083W_CBS436 | rna-NM_001180391.3_CBS436 | cds-NP_010368.5_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:577065-578243:+ | gene-YDR083W_CBS6412 | rna-NM_001180391.3_CBS6412 | cds-NP_010368.5_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:605595-606773:+ | gene-YDR083W_CBS6413 | rna-NM_001180391.3_CBS6413 | cds-NP_010368.5_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:611118-612296:+ | gene-YDR083W_CENPK1137D | rna-NM_001180391.3_CENPK1137D | cds-NP_010368.5_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:591422-592600:+ | gene-YDR083W_EthanolRed | rna-NM_001180391.3_EthanolRed | cds-NP_010368.5_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:598216-599394:+ | gene-YDR083W_FaliES1 | rna-NM_001180391.3_FaliES1 | cds-NP_010368.5_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000358.1:31873-33051:- | gene-YDR083W_JAY291 | rna-NM_001180391.3_JAY291 | cds-NP_010368.5_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:606476-607654:+ | gene-YDR083W_MUCL30387 | rna-NM_001180391.3_MUCL30387 | cds-NP_010368.5_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:596788-597966:+ | gene-YDR083W_MUCL30388 | rna-NM_001180391.3_MUCL30388 | cds-NP_010368.5_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:582020-583198:+ | gene-YDR083W_MUCL39482 | rna-NM_001180391.3_MUCL39482 | cds-NP_010368.5_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:512599-513777:+ | gene-YDR083W_MUCL42920 | rna-NM_001180391.3_MUCL42920 | cds-NP_010368.5_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:611996-613174:+ | gene-YDR083W_NCIM3186 | rna-NM_001180391.3_NCIM3186 | cds-NP_010368.5_NCIM3186 | 93.1 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:580927-582105:+ | gene-YDR083W_NCYC1407 | rna-NM_001180391.3_NCYC1407 | cds-NP_010368.5_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:600397-601575:+ | gene-YDR083W_PE2H3 | rna-NM_001180391.3_PE2H3 | cds-NP_010368.5_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:599702-600880:+ | gene-YDR083W_PE2H4 | rna-NM_001180391.3_PE2H4 | cds-NP_010368.5_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:612073-613251:+ | gene-YDR083W_S288C | rna-NM_001180391.3_S288C | cds-NP_010368.5_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:32084-33262:- | gene-YDR083W_SA1 | rna-NM_001180391.3_SA1 | cds-NP_010368.5_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:597746-598924:+ | gene-YDR083W_ThermosaccDry | rna-NM_001180391.3_ThermosaccDry | cds-NP_010368.5_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:610297-611475:+ | gene-YDR083W_VR1 | rna-NM_001180391.3_VR1 | cds-NP_010368.5_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:595330-596507:+ | gene-YDR083W_ZTW1 | rna-NM_001180391.3_ZTW1 | cds-NP_010368.5_ZTW1 | 99.3 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:600027-601202:+ | gene-YDR083W_Sparadoxus | rna-NM_001180391.3_Sparadoxus | cds-NP_010368.5_Sparadoxus | 91.0 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |