Gene name: RRN3
Reference locus (S288C): YKL125W
Gene biotype: protein_coding
Description: Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family
Top 10 interactors (score): RPA43 (0.999); RPA135 (0.999); RPA190 (0.999); RRN7 (0.998); RPA49 (0.996); RRN6 (0.994); RPC40 (0.994); RPC19 (0.991); RPA12 (0.989); SPT15 (0.985); RPB5 (0.98); RRN11 (0.979); RPC10 (0.976); RPB8 (0.973); RPO26 (0.969); RPB10 (0.958); RPA14 (0.956); RRN5 (0.947); RPA34 (0.929); BRF1 (0.916)
Homologues (species, bitscore): RRN3 (Homo sapiens, 143.7); Rrn3 (Mus musculus, 139.8); rrn3 (Danio rerio, 144.8); rrn3 (Xenopus tropicalis, 147.5); Tif-IA (Drosophila melanogaster, 90.9); C36E8.1 (Caenorhabditis elegans, 62.4); AT2G34750 (Arabidopsis thaliana, 91.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:194822-196705:+ | gene-YKL125W_AKU4011 | rna-NM_001179691.1_AKU4011 | cds-NP_012797.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:171941-173824:+ | gene-YKL125W_BG1 | rna-NM_001179691.1_BG1 | cds-NP_012797.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:212733-214616:+ | gene-YKL125W_Bruggeman | rna-NM_001179691.1_Bruggeman | cds-NP_012797.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:207787-209670:+ | gene-YKL125W_CAT1 | rna-NM_001179691.1_CAT1 | cds-NP_012797.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:207055-208938:+ | gene-YKL125W_CBS1585 | rna-NM_001179691.1_CBS1585 | cds-NP_012797.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:205639-207522:+ | gene-YKL125W_CBS436 | rna-NM_001179691.1_CBS436 | cds-NP_012797.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:191683-193566:+ | gene-YKL125W_CBS6412 | rna-NM_001179691.1_CBS6412 | cds-NP_012797.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:207518-209401:+ | gene-YKL125W_CBS6413 | rna-NM_001179691.1_CBS6413 | cds-NP_012797.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:207888-209771:+ | gene-YKL125W_CENPK1137D | rna-NM_001179691.1_CENPK1137D | cds-NP_012797.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:205552-207435:+ | gene-YKL125W_EthanolRed | rna-NM_001179691.1_EthanolRed | cds-NP_012797.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:206365-208248:+ | gene-YKL125W_FaliES1 | rna-NM_001179691.1_FaliES1 | cds-NP_012797.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000357.1:28660-30543:+ | gene-YKL125W_JAY291 | rna-NM_001179691.1_JAY291 | cds-NP_012797.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:214554-216437:+ | gene-YKL125W_MUCL30387 | rna-NM_001179691.1_MUCL30387 | cds-NP_012797.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:208925-210808:+ | gene-YKL125W_MUCL30388 | rna-NM_001179691.1_MUCL30388 | cds-NP_012797.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:206848-208731:+ | gene-YKL125W_MUCL39482 | rna-NM_001179691.1_MUCL39482 | cds-NP_012797.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:211220-213103:+ | gene-YKL125W_MUCL42920 | rna-NM_001179691.1_MUCL42920 | cds-NP_012797.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:208236-210119:+ | gene-YKL125W_NCIM3186 | rna-NM_001179691.1_NCIM3186 | cds-NP_012797.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:207029-208912:+ | gene-YKL125W_NCYC1407 | rna-NM_001179691.1_NCYC1407 | cds-NP_012797.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:214127-216010:+ | gene-YKL125W_PE2H3 | rna-NM_001179691.1_PE2H3 | cds-NP_012797.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:210415-212298:+ | gene-YKL125W_PE2H4 | rna-NM_001179691.1_PE2H4 | cds-NP_012797.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:208247-210130:+ | gene-YKL125W_S288C | rna-NM_001179691.1_S288C | cds-NP_012797.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:124367-126250:+ | gene-YKL125W_SA1 | rna-NM_001179691.1_SA1 | cds-NP_012797.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:207065-208948:+ | gene-YKL125W_ThermosaccDry | rna-NM_001179691.1_ThermosaccDry | cds-NP_012797.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:206378-208261:+ | gene-YKL125W_VR1 | rna-NM_001179691.1_VR1 | cds-NP_012797.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:205596-207479:+ | gene-YKL125W_ZTW1 | rna-NM_001179691.1_ZTW1 | cds-NP_012797.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:223131-225017:+ | gene-YKL125W_Sparadoxus | rna-NM_001179691.1_Sparadoxus | cds-NP_012797.1_Sparadoxus | 92.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |