Gene name: RRI1
Reference locus (S288C): YDL216C
Gene biotype: protein_coding
Description: Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis; Belongs to the peptidase M67A family. CSN5 subfamily
Top 10 interactors (score): CDC53 (0.999); RPN5 (0.999); CUL3 (0.999); HRT1 (0.998); RRI2 (0.997); CSI1 (0.997); CSN9 (0.997); BRR2 (0.996); PCI8 (0.996); RPN7 (0.995); RPN3 (0.982); SKP1 (0.98); RPN10 (0.976); RTT101 (0.974); UBA3 (0.973); RPN8 (0.969); DCN1 (0.969); ATP1 (0.965); KAR2 (0.961); AAR2 (0.96)
Homologues (species, bitscore): COPS5 (Homo sapiens, 160.6); Cops5 (Mus musculus, 160.6); cops5 (Danio rerio, 159.5); cops5 (Xenopus tropicalis, 161.0); CSN5 (Drosophila melanogaster, 152.9); csn-5 (Caenorhabditis elegans, 162.9); CSN5A (Arabidopsis thaliana, 161.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:52491-53813:- | gene-YDL216C_AKU4011 | rna-NM_001180276.1_AKU4011 | cds-NP_010065.2_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000077.1:13257-14579:+ | gene-YDL216C_BG1 | rna-NM_001180276.1_BG1 | cds-NP_010065.2_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:68167-69489:- | gene-YDL216C_Bruggeman | rna-NM_001180276.1_Bruggeman | cds-NP_010065.2_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:288017-289339:- | gene-YDL216C_CAT1 | rna-NM_001180276.1_CAT1 | cds-NP_010065.2_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:51366-52688:- | gene-YDL216C_CBS1585 | rna-NM_001180276.1_CBS1585 | cds-NP_010065.2_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:266248-267570:- | gene-YDL216C_CBS436 | rna-NM_001180276.1_CBS436 | cds-NP_010065.2_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:51478-52800:- | gene-YDL216C_CBS6412 | rna-NM_001180276.1_CBS6412 | cds-NP_010065.2_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:69001-70323:- | gene-YDL216C_CBS6413 | rna-NM_001180276.1_CBS6413 | cds-NP_010065.2_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:67663-68985:- | gene-YDL216C_CENPK1137D | rna-NM_001180276.1_CENPK1137D | cds-NP_010065.2_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:64937-66259:- | gene-YDL216C_EthanolRed | rna-NM_001180276.1_EthanolRed | cds-NP_010065.2_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:69264-70586:- | gene-YDL216C_FaliES1 | rna-NM_001180276.1_FaliES1 | cds-NP_010065.2_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000213.1:23592-24914:- | gene-YDL216C_JAY291 | rna-NM_001180276.1_JAY291 | cds-NP_010065.2_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:67116-68438:- | gene-YDL216C_MUCL30387 | rna-NM_001180276.1_MUCL30387 | cds-NP_010065.2_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:274934-276256:- | gene-YDL216C_MUCL30388 | rna-NM_001180276.1_MUCL30388 | cds-NP_010065.2_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:52209-53531:- | gene-YDL216C_MUCL39482 | rna-NM_001180276.1_MUCL39482 | cds-NP_010065.2_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:68265-69587:- | gene-YDL216C_MUCL42920 | rna-NM_001180276.1_MUCL42920 | cds-NP_010065.2_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:68920-70242:- | gene-YDL216C_NCIM3186 | rna-NM_001180276.1_NCIM3186 | cds-NP_010065.2_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:52165-53487:- | gene-YDL216C_NCYC1407 | rna-NM_001180276.1_NCYC1407 | cds-NP_010065.2_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:59205-60527:- | gene-YDL216C_PE2H3 | rna-NM_001180276.1_PE2H3 | cds-NP_010065.2_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:59215-60537:- | gene-YDL216C_PE2H4 | rna-NM_001180276.1_PE2H4 | cds-NP_010065.2_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:68997-70319:- | gene-YDL216C_S288C | rna-NM_001180276.1_S288C | cds-NP_010065.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000094.1:23400-24722:- | gene-YDL216C_SA1 | rna-NM_001180276.1_SA1 | cds-NP_010065.2_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:69019-70341:- | gene-YDL216C_ThermosaccDry | rna-NM_001180276.1_ThermosaccDry | cds-NP_010065.2_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:69972-71294:- | gene-YDL216C_VR1 | rna-NM_001180276.1_VR1 | cds-NP_010065.2_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:68189-69511:- | gene-YDL216C_ZTW1 | rna-NM_001180276.1_ZTW1 | cds-NP_010065.2_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:71569-72891:- | gene-YDL216C_Sparadoxus | rna-NM_001180276.1_Sparadoxus | cds-NP_010065.2_Sparadoxus | 87.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |