Gene name: RQC2
Reference locus (S288C): YPL009C
Gene biotype: protein_coding
Description: Ribosome quality control complex subunit 2; Component of RQC, which mediates nascent chain degradation; RQC (ribosome quality control complex) is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of nascent chains independently of mRNA or 40S subunits; monitors translation stress and signals this to Hsf1p; Belongs to the NEMF family
Top 10 interactors (score): RKR1 (0.999); CDC48 (0.999); RQC1 (0.999); NPL4 (0.988); UFD1 (0.988); VMS1 (0.985); DOM34 (0.955); HBS1 (0.952); SLH1 (0.94); HEL2 (0.925); YKR023W (0.912); RLI1 (0.883); RPS20 (0.847); CBF5 (0.837); CUE3 (0.828); RPS10B (0.803); RPS10A (0.802); SKI7 (0.795); RPS18A (0.779); JLP2 (0.774)
Homologues (species, bitscore): NEMF (Homo sapiens, 342.8); Nemf (Mus musculus, 327.0); nemf (Xenopus tropicalis, 301.2); Clbn (Drosophila melanogaster, 289.3); Y82E9BR.18 (Caenorhabditis elegans, 247.3); emb1441 (Arabidopsis thaliana, 247.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:507309-510392:- | gene-YPL009C_AKU4011 | rna-NM_001183823.1_AKU4011 | cds-NP_015316.1_AKU4011 | 98.4 | 98.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:386782-389910:+ | gene-YPL009C_BG1 | rna-NM_001183823.1_BG1 | cds-NP_015316.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:584246-587335:- | gene-YPL009C_Bruggeman | rna-NM_001183823.1_Bruggeman | cds-NP_015316.1_Bruggeman | 98.9 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:626710-630081:- | gene-YPL009C_CAT1 | rna-NM_001183823.1_CAT1 | cds-NP_015316.1_CAT1 | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:511471-514569:- | gene-YPL009C_CBS1585 | rna-NM_001183823.1_CBS1585 | cds-NP_015316.1_CBS1585 | 99.0 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:525518-528637:- | gene-YPL009C_CBS436 | rna-NM_001183823.1_CBS436 | cds-NP_015316.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:515223-518318:- | gene-YPL009C_CBS6412 | rna-NM_001183823.1_CBS6412 | cds-NP_015316.1_CBS6412 | 98.9 | 99.3 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:507946-511029:- | gene-YPL009C_CBS6413 | rna-NM_001183823.1_CBS6413 | cds-NP_015316.1_CBS6413 | 98.4 | 98.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:535827-538937:- | gene-YPL009C_CENPK1137D | rna-NM_001183823.1_CENPK1137D | cds-NP_015316.1_CENPK1137D | 99.8 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:505730-508816:- | gene-YPL009C_EthanolRed | rna-NM_001183823.1_EthanolRed | cds-NP_015316.1_EthanolRed | 98.5 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:513560-516646:- | gene-YPL009C_FaliES1 | rna-NM_001183823.1_FaliES1 | cds-NP_015316.1_FaliES1 | 98.5 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000341.1:21367-23553:+ | gene-YPL009C_JAY291 | rna-NM_001183823.1_JAY291 | cds-NP_015316.1_JAY291 | 69.9 | 70.1 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:525199-528288:- | gene-YPL009C_MUCL30387 | rna-NM_001183823.1_MUCL30387 | cds-NP_015316.1_MUCL30387 | 98.8 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:524303-527392:- | gene-YPL009C_MUCL30388 | rna-NM_001183823.1_MUCL30388 | cds-NP_015316.1_MUCL30388 | 98.9 | 99.1 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:504711-507809:- | gene-YPL009C_MUCL39482 | rna-NM_001183823.1_MUCL39482 | cds-NP_015316.1_MUCL39482 | 99.0 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:563787-566906:- | gene-YPL009C_MUCL42920 | rna-NM_001183823.1_MUCL42920 | cds-NP_015316.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:535803-538919:- | gene-YPL009C_NCIM3186 | rna-NM_001183823.1_NCIM3186 | cds-NP_015316.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:511985-515068:- | gene-YPL009C_NCYC1407 | rna-NM_001183823.1_NCYC1407 | cds-NP_015316.1_NCYC1407 | 98.4 | 98.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:518639-521767:- | gene-YPL009C_PE2H3 | rna-NM_001183823.1_PE2H3 | cds-NP_015316.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:518254-521382:- | gene-YPL009C_PE2H4 | rna-NM_001183823.1_PE2H4 | cds-NP_015316.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:535820-538936:- | gene-YPL009C_S288C | rna-NM_001183823.1_S288C | cds-NP_015316.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000076.1:32549-35677:- | gene-YPL009C_SA1 | rna-NM_001183823.1_SA1 | cds-NP_015316.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:513359-516445:- | gene-YPL009C_ThermosaccDry | rna-NM_001183823.1_ThermosaccDry | cds-NP_015316.1_ThermosaccDry | 98.5 | 99.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:528739-531843:- | gene-YPL009C_VR1 | rna-NM_001183823.1_VR1 | cds-NP_015316.1_VR1 | 99.3 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:512644-515751:- | gene-YPL009C_ZTW1 | rna-NM_001183823.1_ZTW1 | cds-NP_015316.1_ZTW1 | 99.3 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:512525-515568:- | gene-YPL009C_Sparadoxus | rna-NM_001183823.1_Sparadoxus | cds-NP_015316.1_Sparadoxus | 85.4 | 97.4 | Verified | 1 | 1 | 0 | False | False | False | True | False |