Gene name: RPH1
Reference locus (S288C): YER169W
Gene biotype: protein_coding
Description: DNA damage-responsive transcriptional repressor RPH1; JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication
Top 10 interactors (score): JHD1 (0.985); SET2 (0.964); HHT2 (0.946); ECM5 (0.925); LRG1 (0.908); HHT1 (0.896); SET1 (0.893); SAS2 (0.869); GIS1 (0.866); ESA1 (0.864); SCH9 (0.848); SAS3 (0.847); HTB1 (0.819); JHD2 (0.808); TEL1 (0.803); GCN5 (0.789); RAD53 (0.785); PHR1 (0.772); SET6 (0.765); FMS1 (0.755)
Homologues (species, bitscore): JHDM3C (Homo sapiens, 265.4); Kdm4c (Mus musculus, 266.2); kdm4b (Danio rerio, 268.1); kdm4a (Xenopus tropicalis, 258.8); Kdm4B (Drosophila melanogaster, 260.8); jmjd-2 (Caenorhabditis elegans, 217.6); PKDM7D (Arabidopsis thaliana, 167.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:504890-507280:+ | gene-YER169W_AKU4011 | rna-NM_001179059.1_AKU4011 | cds-NP_011096.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000176.1:26084-28474:- | gene-YER169W_BG1 | rna-NM_001179059.1_BG1 | cds-NP_011096.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:517632-520022:+ | gene-YER169W_Bruggeman | rna-NM_001179059.1_Bruggeman | cds-NP_011096.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:504224-506614:+ | gene-YER169W_CAT1 | rna-NM_001179059.1_CAT1 | cds-NP_011096.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:504697-507087:+ | gene-YER169W_CBS1585 | rna-NM_001179059.1_CBS1585 | cds-NP_011096.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:514592-516982:+ | gene-YER169W_CBS436 | rna-NM_001179059.1_CBS436 | cds-NP_011096.1_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:502674-505064:+ | gene-YER169W_CBS6412 | rna-NM_001179059.1_CBS6412 | cds-NP_011096.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:511243-513633:+ | gene-YER169W_CBS6413 | rna-NM_001179059.1_CBS6413 | cds-NP_011096.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:521138-523528:+ | gene-YER169W_CENPK1137D | rna-NM_001179059.1_CENPK1137D | cds-NP_011096.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:510864-513254:+ | gene-YER169W_EthanolRed | rna-NM_001179059.1_EthanolRed | cds-NP_011096.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:511800-514190:+ | gene-YER169W_FaliES1 | rna-NM_001179059.1_FaliES1 | cds-NP_011096.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000169.1:25716-28106:- | gene-YER169W_JAY291 | rna-NM_001179059.1_JAY291 | cds-NP_011096.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:504947-507337:+ | gene-YER169W_MUCL30387 | rna-NM_001179059.1_MUCL30387 | cds-NP_011096.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:507863-510253:+ | gene-YER169W_MUCL30388 | rna-NM_001179059.1_MUCL30388 | cds-NP_011096.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:500655-503045:+ | gene-YER169W_MUCL39482 | rna-NM_001179059.1_MUCL39482 | cds-NP_011096.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:515179-517569:+ | gene-YER169W_MUCL42920 | rna-NM_001179059.1_MUCL42920 | cds-NP_011096.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:523368-525758:+ | gene-YER169W_NCIM3186 | rna-NM_001179059.1_NCIM3186 | cds-NP_011096.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:510110-512500:+ | gene-YER169W_NCYC1407 | rna-NM_001179059.1_NCYC1407 | cds-NP_011096.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:526043-528433:+ | gene-YER169W_PE2H3 | rna-NM_001179059.1_PE2H3 | cds-NP_011096.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:515984-518374:+ | gene-YER169W_PE2H4 | rna-NM_001179059.1_PE2H4 | cds-NP_011096.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:523369-525759:+ | gene-YER169W_S288C | rna-NM_001179059.1_S288C | cds-NP_011096.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000030.1:75521-77911:+ | gene-YER169W_SA1 | rna-NM_001179059.1_SA1 | cds-NP_011096.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:512600-514990:+ | gene-YER169W_ThermosaccDry | rna-NM_001179059.1_ThermosaccDry | cds-NP_011096.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:505889-508279:+ | gene-YER169W_VR1 | rna-NM_001179059.1_VR1 | cds-NP_011096.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000011.1:25447-27837:+ | gene-YER169W_ZTW1 | rna-NM_001179059.1_ZTW1 | cds-NP_011096.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:513823-516213:+ | gene-YER169W_Sparadoxus | rna-NM_001179059.1_Sparadoxus | cds-NP_011096.1_Sparadoxus | 89.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |