Gene name: ROX1
Reference locus (S288C): YPR065W
Gene biotype: protein_coding
Description: Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
Top 10 interactors (score): MOT3 (0.983); CYC8 (0.967); TUP1 (0.926); ANB1 (0.905); HEM13 (0.902); CYC7 (0.902); UPC2 (0.855); IXR1 (0.826); YAP6 (0.811); SKN7 (0.784); HAP4 (0.782); SOK2 (0.781); GSY1 (0.78); J1120 (0.765); AFT1 (0.763); GCN4 (0.761); ECM22 (0.751); COX5B (0.749); MSN2 (0.749); DAN1 (0.749)
Homologues (species, bitscore): SOX12 (Homo sapiens, 68.2); Sox12 (Mus musculus, 68.2); sox7 (Danio rerio, 64.7); sox7 (Xenopus tropicalis, 63.5); Sox100B (Drosophila melanogaster, 62.0); sem-2 (Caenorhabditis elegans, 69.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:651364-652473:+ | gene-YPR065W_AKU4011 | rna-NM_001184162.1_AKU4011 | cds-NP_015390.1_AKU4011 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:245214-246320:- | gene-YPR065W_BG1 | rna-NM_001184162.1_BG1 | cds-NP_015390.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:729031-730140:+ | gene-YPR065W_Bruggeman | rna-NM_001184162.1_Bruggeman | cds-NP_015390.1_Bruggeman | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:772482-773588:+ | gene-YPR065W_CAT1 | rna-NM_001184162.1_CAT1 | cds-NP_015390.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:655052-656161:+ | gene-YPR065W_CBS1585 | rna-NM_001184162.1_CBS1585 | cds-NP_015390.1_CBS1585 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:669424-670530:+ | gene-YPR065W_CBS436 | rna-NM_001184162.1_CBS436 | cds-NP_015390.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:658798-659907:+ | gene-YPR065W_CBS6412 | rna-NM_001184162.1_CBS6412 | cds-NP_015390.1_CBS6412 | 98.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:651998-653107:+ | gene-YPR065W_CBS6413 | rna-NM_001184162.1_CBS6413 | cds-NP_015390.1_CBS6413 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:679656-680762:+ | gene-YPR065W_CENPK1137D | rna-NM_001184162.1_CENPK1137D | cds-NP_015390.1_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:978558-979667:+ | gene-YPR065W_EthanolRed | rna-NM_001184162.1_EthanolRed | cds-NP_015390.1_EthanolRed | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:657195-658304:+ | gene-YPR065W_FaliES1 | rna-NM_001184162.1_FaliES1 | cds-NP_015390.1_FaliES1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000446.1:29144-30250:+ | gene-YPR065W_JAY291 | rna-NM_001184162.1_JAY291 | cds-NP_015390.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:670291-671400:+ | gene-YPR065W_MUCL30387 | rna-NM_001184162.1_MUCL30387 | cds-NP_015390.1_MUCL30387 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:668996-670105:+ | gene-YPR065W_MUCL30388 | rna-NM_001184162.1_MUCL30388 | cds-NP_015390.1_MUCL30388 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:648309-649418:+ | gene-YPR065W_MUCL39482 | rna-NM_001184162.1_MUCL39482 | cds-NP_015390.1_MUCL39482 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:711132-712241:+ | gene-YPR065W_MUCL42920 | rna-NM_001184162.1_MUCL42920 | cds-NP_015390.1_MUCL42920 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:679676-680782:+ | gene-YPR065W_NCIM3186 | rna-NM_001184162.1_NCIM3186 | cds-NP_015390.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:656237-657346:+ | gene-YPR065W_NCYC1407 | rna-NM_001184162.1_NCYC1407 | cds-NP_015390.1_NCYC1407 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:662447-663553:+ | gene-YPR065W_PE2H3 | rna-NM_001184162.1_PE2H3 | cds-NP_015390.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:662095-663201:+ | gene-YPR065W_PE2H4 | rna-NM_001184162.1_PE2H4 | cds-NP_015390.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:679693-680799:+ | gene-YPR065W_S288C | rna-NM_001184162.1_S288C | cds-NP_015390.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000026.1:19891-20997:- | gene-YPR065W_SA1 | rna-NM_001184162.1_SA1 | cds-NP_015390.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:656970-658079:+ | gene-YPR065W_ThermosaccDry | rna-NM_001184162.1_ThermosaccDry | cds-NP_015390.1_ThermosaccDry | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:673121-674227:+ | gene-YPR065W_VR1 | rna-NM_001184162.1_VR1 | cds-NP_015390.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:656193-657302:+ | gene-YPR065W_ZTW1 | rna-NM_001184162.1_ZTW1 | cds-NP_015390.1_ZTW1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:656957-658072:+ | gene-YPR065W_Sparadoxus | rna-NM_001184162.1_Sparadoxus | cds-NP_015390.1_Sparadoxus | 87.5 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |