Gene name: ROT2
Reference locus (S288C): YBR229C
Gene biotype: protein_coding
Description: Mannosyl-oligosaccharide alpha-1,3-glucosidase; Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
Top 10 interactors (score): GTB1 (0.999); CWH41 (0.998); CNE1 (0.993); KRE5 (0.96); MNS1 (0.952); ALG8 (0.948); OST3 (0.938); YUR1 (0.92); ALG6 (0.914); KRE1 (0.905); ROT1 (0.904); BIG1 (0.895); KAR2 (0.87); PMT2 (0.867); OST6 (0.849); ERO1 (0.837); KRE6 (0.818); DGR2 (0.816); ERV41 (0.802); HAC1 (0.801)
Homologues (species, bitscore): GANAB (Homo sapiens, 572.4); Ganab (Mus musculus, 566.6); ganab (Danio rerio, 583.2); ganab (Xenopus tropicalis, 570.5); CG14476 (Drosophila melanogaster, 538.1); aagr-3 (Caenorhabditis elegans, 535.8); RSW3 (Arabidopsis thaliana, 566.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:660666-663530:- | gene-YBR229C_AKU4011 | rna-NM_001178577.3_AKU4011 | cds-NP_009788.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000066.1:31585-34449:- | gene-YBR229C_BG1 | rna-NM_001178577.3_BG1 | cds-NP_009788.3_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:661819-664683:- | gene-YBR229C_Bruggeman | rna-NM_001178577.3_Bruggeman | cds-NP_009788.3_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:665024-667888:- | gene-YBR229C_CAT1 | rna-NM_001178577.3_CAT1 | cds-NP_009788.3_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:652198-655062:- | gene-YBR229C_CBS1585 | rna-NM_001178577.3_CBS1585 | cds-NP_009788.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:658621-661485:- | gene-YBR229C_CBS436 | rna-NM_001178577.3_CBS436 | cds-NP_009788.3_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:747175-750039:- | gene-YBR229C_CBS6412 | rna-NM_001178577.3_CBS6412 | cds-NP_009788.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:658236-661100:- | gene-YBR229C_CBS6413 | rna-NM_001178577.3_CBS6413 | cds-NP_009788.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:670135-672999:- | gene-YBR229C_CENPK1137D | rna-NM_001178577.3_CENPK1137D | cds-NP_009788.3_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:783907-786771:- | gene-YBR229C_EthanolRed | rna-NM_001178577.3_EthanolRed | cds-NP_009788.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:677014-679878:- | gene-YBR229C_FaliES1 | rna-NM_001178577.3_FaliES1 | cds-NP_009788.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000067.1:122475-125339:+ | gene-YBR229C_JAY291 | rna-NM_001178577.3_JAY291 | cds-NP_009788.3_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:663833-666697:- | gene-YBR229C_MUCL30387 | rna-NM_001178577.3_MUCL30387 | cds-NP_009788.3_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:680912-683776:- | gene-YBR229C_MUCL30388 | rna-NM_001178577.3_MUCL30388 | cds-NP_009788.3_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:650550-653414:- | gene-YBR229C_MUCL39482 | rna-NM_001178577.3_MUCL39482 | cds-NP_009788.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:660391-663255:- | gene-YBR229C_MUCL42920 | rna-NM_001178577.3_MUCL42920 | cds-NP_009788.3_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:676154-679018:- | gene-YBR229C_NCIM3186 | rna-NM_001178577.3_NCIM3186 | cds-NP_009788.3_NCIM3186 | 97.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:652412-655276:- | gene-YBR229C_NCYC1407 | rna-NM_001178577.3_NCYC1407 | cds-NP_009788.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:675526-678390:- | gene-YBR229C_PE2H3 | rna-NM_001178577.3_PE2H3 | cds-NP_009788.3_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:673202-676066:- | gene-YBR229C_PE2H4 | rna-NM_001178577.3_PE2H4 | cds-NP_009788.3_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:676357-679221:- | gene-YBR229C_S288C | rna-NM_001178577.3_S288C | cds-NP_009788.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000019.1:31483-34347:- | gene-YBR229C_SA1 | rna-NM_001178577.3_SA1 | cds-NP_009788.3_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:676024-678888:- | gene-YBR229C_ThermosaccDry | rna-NM_001178577.3_ThermosaccDry | cds-NP_009788.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:656199-659063:- | gene-YBR229C_VR1 | rna-NM_001178577.3_VR1 | cds-NP_009788.3_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:648890-651754:- | gene-YBR229C_ZTW1 | rna-NM_001178577.3_ZTW1 | cds-NP_009788.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:692868-695732:- | gene-YBR229C_Sparadoxus | rna-NM_001178577.3_Sparadoxus | cds-NP_009788.3_Sparadoxus | 88.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |