Gene name: ROT1
Reference locus (S288C): YMR200W
Gene biotype: protein_coding
Description: Protein ROT1; Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface
Top 10 interactors (score): BIG1 (0.913); ROT2 (0.904); CWH41 (0.902); KRE5 (0.866); KEG1 (0.865); KAR2 (0.865); KRE6 (0.811); PHS1 (0.744); TOR2 (0.742); BRR6 (0.719); MNL2 (0.716); GAS1 (0.715); COS5 (0.711); CNE1 (0.698); TED1 (0.664); OST3 (0.645); SAC7 (0.634); SEC20 (0.61); SEC59 (0.592); MNS1 (0.584)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:704665-705435:+ | gene-YMR200W_AKU4011 | rna-NM_001182707.1_AKU4011 | cds-NP_013927.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:249147-249917:- | gene-YMR200W_BG1 | rna-NM_001182707.1_BG1 | cds-NP_013927.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:648891-649661:+ | gene-YMR200W_Bruggeman | rna-NM_001182707.1_Bruggeman | cds-NP_013927.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:652143-652913:+ | gene-YMR200W_CAT1 | rna-NM_001182707.1_CAT1 | cds-NP_013927.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:636921-637691:+ | gene-YMR200W_CBS1585 | rna-NM_001182707.1_CBS1585 | cds-NP_013927.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:641190-641960:+ | gene-YMR200W_CBS436 | rna-NM_001182707.1_CBS436 | cds-NP_013927.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:748479-749249:+ | gene-YMR200W_CBS6412 | rna-NM_001182707.1_CBS6412 | cds-NP_013927.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:636071-636841:+ | gene-YMR200W_CBS6413 | rna-NM_001182707.1_CBS6413 | cds-NP_013927.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:659441-660211:+ | gene-YMR200W_CENPK1137D | rna-NM_001182707.1_CENPK1137D | cds-NP_013927.1_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:697113-697883:+ | gene-YMR200W_EthanolRed | rna-NM_001182707.1_EthanolRed | cds-NP_013927.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:642767-643537:+ | gene-YMR200W_FaliES1 | rna-NM_001182707.1_FaliES1 | cds-NP_013927.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000141.1:142464-143234:- | gene-YMR200W_JAY291 | rna-NM_001182707.1_JAY291 | cds-NP_013927.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:642438-643208:+ | gene-YMR200W_MUCL30387 | rna-NM_001182707.1_MUCL30387 | cds-NP_013927.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:649213-649983:+ | gene-YMR200W_MUCL30388 | rna-NM_001182707.1_MUCL30388 | cds-NP_013927.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:637993-638763:+ | gene-YMR200W_MUCL39482 | rna-NM_001182707.1_MUCL39482 | cds-NP_013927.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:645333-646103:+ | gene-YMR200W_MUCL42920 | rna-NM_001182707.1_MUCL42920 | cds-NP_013927.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:664706-665476:+ | gene-YMR200W_NCIM3186 | rna-NM_001182707.1_NCIM3186 | cds-NP_013927.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:637644-638414:+ | gene-YMR200W_NCYC1407 | rna-NM_001182707.1_NCYC1407 | cds-NP_013927.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:647503-648273:+ | gene-YMR200W_PE2H3 | rna-NM_001182707.1_PE2H3 | cds-NP_013927.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:648522-649292:+ | gene-YMR200W_PE2H4 | rna-NM_001182707.1_PE2H4 | cds-NP_013927.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:664752-665522:+ | gene-YMR200W_S288C | rna-NM_001182707.1_S288C | cds-NP_013927.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:142590-143360:- | gene-YMR200W_SA1 | rna-NM_001182707.1_SA1 | cds-NP_013927.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:638894-639664:+ | gene-YMR200W_ThermosaccDry | rna-NM_001182707.1_ThermosaccDry | cds-NP_013927.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:652036-652806:+ | gene-YMR200W_VR1 | rna-NM_001182707.1_VR1 | cds-NP_013927.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:54671-55441:+ | gene-YMR200W_ZTW1 | rna-NM_001182707.1_ZTW1 | cds-NP_013927.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:656816-657586:+ | gene-YMR200W_Sparadoxus | rna-NM_001182707.1_Sparadoxus | cds-NP_013927.1_Sparadoxus | 90.8 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |