Gene name: ROM2
Reference locus (S288C): YLR371W
Gene biotype: protein_coding
Description: Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication
Top 10 interactors (score): SLG1 (0.999); RHO1 (0.999); MID2 (0.995); MTL1 (0.978); LRG1 (0.974); WSC2 (0.973); RHO2 (0.972); PKC1 (0.959); WSC3 (0.954); SLT2 (0.949); FKS1 (0.943); BCK1 (0.934); ROM1 (0.895); BEM2 (0.889); TOR2 (0.887); SMI1 (0.876); MKK1 (0.874); SAC7 (0.863); TUS1 (0.853); ACK1 (0.853)
Homologues (species, bitscore): ARHGEF1 (Homo sapiens, 87.4); Net1 (Mus musculus, 89.4); net1 (Danio rerio, 89.4); arhgef12 (Xenopus tropicalis, 86.3); CG10188 (Drosophila melanogaster, 66.6); tag-52 (Caenorhabditis elegans, 60.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:812252-816319:+ | gene-YLR371W_AKU4011 | rna-NM_001182260.1_AKU4011 | cds-NP_013475.1_AKU4011 | 99.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:44403-48470:+ | gene-YLR371W_BG1 | rna-NM_001182260.1_BG1 | cds-NP_013475.1_BG1 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:850574-854653:+ | gene-YLR371W_Bruggeman | rna-NM_001182260.1_Bruggeman | cds-NP_013475.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:846079-850146:+ | gene-YLR371W_CAT1 | rna-NM_001182260.1_CAT1 | cds-NP_013475.1_CAT1 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:847242-851309:+ | gene-YLR371W_CBS1585 | rna-NM_001182260.1_CBS1585 | cds-NP_013475.1_CBS1585 | 99.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:831484-835551:+ | gene-YLR371W_CBS436 | rna-NM_001182260.1_CBS436 | cds-NP_013475.1_CBS436 | 99.4 | 99.9 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:884252-888331:+ | gene-YLR371W_CBS6412 | rna-NM_001182260.1_CBS6412 | cds-NP_013475.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:848135-852202:+ | gene-YLR371W_CBS6413 | rna-NM_001182260.1_CBS6413 | cds-NP_013475.1_CBS6413 | 99.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:847439-851518:+ | gene-YLR371W_CENPK1137D | rna-NM_001182260.1_CENPK1137D | cds-NP_013475.1_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:804821-808900:+ | gene-YLR371W_EthanolRed | rna-NM_001182260.1_EthanolRed | cds-NP_013475.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:833626-837705:+ | gene-YLR371W_FaliES1 | rna-NM_001182260.1_FaliES1 | cds-NP_013475.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000161.1:44220-48288:+ | gene-YLR371W_JAY291 | rna-NM_001182260.1_JAY291 | cds-NP_013475.1_JAY291 | 99.4 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:847990-852057:+ | gene-YLR371W_MUCL30387 | rna-NM_001182260.1_MUCL30387 | cds-NP_013475.1_MUCL30387 | 99.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:853608-857687:+ | gene-YLR371W_MUCL30388 | rna-NM_001182260.1_MUCL30388 | cds-NP_013475.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:848461-852528:+ | gene-YLR371W_MUCL39482 | rna-NM_001182260.1_MUCL39482 | cds-NP_013475.1_MUCL39482 | 99.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:843746-847825:+ | gene-YLR371W_MUCL42920 | rna-NM_001182260.1_MUCL42920 | cds-NP_013475.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:862688-866758:+ | gene-YLR371W_NCIM3186 | rna-NM_001182260.1_NCIM3186 | cds-NP_013475.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:857683-861750:+ | gene-YLR371W_NCYC1407 | rna-NM_001182260.1_NCYC1407 | cds-NP_013475.1_NCYC1407 | 99.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:844641-848708:+ | gene-YLR371W_PE2H3 | rna-NM_001182260.1_PE2H3 | cds-NP_013475.1_PE2H3 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:844385-848452:+ | gene-YLR371W_PE2H4 | rna-NM_001182260.1_PE2H4 | cds-NP_013475.1_PE2H4 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:862714-866784:+ | gene-YLR371W_S288C | rna-NM_001182260.1_S288C | cds-NP_013475.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:181908-185975:- | gene-YLR371W_SA1 | rna-NM_001182260.1_SA1 | cds-NP_013475.1_SA1 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:836458-840786:+ | gene-YLR371W_ThermosaccDry | rna-NM_001182260.1_ThermosaccDry | cds-NP_013475.1_ThermosaccDry | 93.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:849731-853798:+ | gene-YLR371W_VR1 | rna-NM_001182260.1_VR1 | cds-NP_013475.1_VR1 | 99.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:173908-177972:+ | gene-YLR371W_ZTW1 | rna-NM_001182260.1_ZTW1 | cds-NP_013475.1_ZTW1 | 99.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:822608-826666:+ | gene-YLR371W_Sparadoxus | rna-NM_001182260.1_Sparadoxus | cds-NP_013475.1_Sparadoxus | 91.6 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |