Gene name: RNR4
Reference locus (S288C): YGR180C
Gene biotype: protein_coding
Description: Ribonucleoside-diphosphate reductase small chain 2; Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication
Top 10 interactors (score): RNR3 (0.999); RNR2 (0.999); RNR1 (0.999); ASF1 (0.975); CDC21 (0.961); WTM1 (0.959); CDC8 (0.955); MCM2 (0.945); DUT1 (0.938); RFA2 (0.935); PRI1 (0.934); POL30 (0.93); MCM7 (0.929); GUK1 (0.929); MEC1 (0.927); MCM5 (0.92); DUN1 (0.919); CDC19 (0.916); YNK1 (0.915); RFA1 (0.91)
Homologues (species, bitscore): RRM2 (Homo sapiens, 324.3); Rrm2 (Mus musculus, 330.5); rrm2 (Danio rerio, 325.9); rrm2.1 (Xenopus tropicalis, 330.5); RnrS (Drosophila melanogaster, 315.1); rnr-2 (Caenorhabditis elegans, 295.4); RNR2A (Arabidopsis thaliana, 297.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:823016-824053:- | gene-YGR180C_AKU4011 | rna-NM_001181309.3_AKU4011 | cds-NP_011696.3_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:101128-102165:- | gene-YGR180C_BG1 | rna-NM_001181309.3_BG1 | cds-NP_011696.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:828945-829982:- | gene-YGR180C_Bruggeman | rna-NM_001181309.3_Bruggeman | cds-NP_011696.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:825041-826078:- | gene-YGR180C_CAT1 | rna-NM_001181309.3_CAT1 | cds-NP_011696.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:823732-824769:- | gene-YGR180C_CBS1585 | rna-NM_001181309.3_CBS1585 | cds-NP_011696.3_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:827622-828659:- | gene-YGR180C_CBS436 | rna-NM_001181309.3_CBS436 | cds-NP_011696.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:815102-816139:- | gene-YGR180C_CBS6412 | rna-NM_001181309.3_CBS6412 | cds-NP_011696.3_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:820598-821635:- | gene-YGR180C_CBS6413 | rna-NM_001181309.3_CBS6413 | cds-NP_011696.3_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:854988-856025:- | gene-YGR180C_CENPK1137D | rna-NM_001181309.3_CENPK1137D | cds-NP_011696.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:809608-810645:- | gene-YGR180C_EthanolRed | rna-NM_001181309.3_EthanolRed | cds-NP_011696.3_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:813999-815036:- | gene-YGR180C_FaliES1 | rna-NM_001181309.3_FaliES1 | cds-NP_011696.3_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000226.1:1106-2143:+ | gene-YGR180C_JAY291 | rna-NM_001181309.3_JAY291 | cds-NP_011696.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:826435-827472:- | gene-YGR180C_MUCL30387 | rna-NM_001181309.3_MUCL30387 | cds-NP_011696.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:826146-827183:- | gene-YGR180C_MUCL30388 | rna-NM_001181309.3_MUCL30388 | cds-NP_011696.3_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:819308-820345:- | gene-YGR180C_MUCL39482 | rna-NM_001181309.3_MUCL39482 | cds-NP_011696.3_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:835923-836960:- | gene-YGR180C_MUCL42920 | rna-NM_001181309.3_MUCL42920 | cds-NP_011696.3_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:855264-856301:- | gene-YGR180C_NCIM3186 | rna-NM_001181309.3_NCIM3186 | cds-NP_011696.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:814417-815454:- | gene-YGR180C_NCYC1407 | rna-NM_001181309.3_NCYC1407 | cds-NP_011696.3_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:833612-834649:- | gene-YGR180C_PE2H3 | rna-NM_001181309.3_PE2H3 | cds-NP_011696.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:838722-839759:- | gene-YGR180C_PE2H4 | rna-NM_001181309.3_PE2H4 | cds-NP_011696.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:855264-856301:- | gene-YGR180C_S288C | rna-NM_001181309.3_S288C | cds-NP_011696.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000035.1:78981-80018:- | gene-YGR180C_SA1 | rna-NM_001181309.3_SA1 | cds-NP_011696.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:834510-835547:- | gene-YGR180C_ThermosaccDry | rna-NM_001181309.3_ThermosaccDry | cds-NP_011696.3_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:938757-939794:- | gene-YGR180C_VR1 | rna-NM_001181309.3_VR1 | cds-NP_011696.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:135948-136985:- | gene-YGR180C_ZTW1 | rna-NM_001181309.3_ZTW1 | cds-NP_011696.3_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:825683-826720:- | gene-YGR180C_Sparadoxus | rna-NM_001181309.3_Sparadoxus | cds-NP_011696.3_Sparadoxus | 94.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |