Gene name: RNR1
Reference locus (S288C): YER070W
Gene biotype: protein_coding
Description: Ribonucleoside-diphosphate reductase large chain 1; Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication
Top 10 interactors (score): RNR4 (0.999); RNR2 (0.999); POL30 (0.993); RNR3 (0.989); MCM7 (0.988); MCM5 (0.987); CDC21 (0.986); SML1 (0.985); DUN1 (0.984); POL1 (0.984); RAD53 (0.969); CDC8 (0.967); CDC6 (0.966); MCM4 (0.964); MEC1 (0.963); PRI1 (0.959); PRI2 (0.959); MCM2 (0.958); POL12 (0.957); POL2 (0.955)
Homologues (species, bitscore): RRM1 (Homo sapiens, 1116.3); Rrm1 (Mus musculus, 1112.4); rrm1 (Danio rerio, 1134.8); rrm1 (Xenopus tropicalis, 1107.0); RnrL (Drosophila melanogaster, 1090.9); rnr-1 (Caenorhabditis elegans, 1106.3); RNR1 (Arabidopsis thaliana, 1092.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:292729-295395:+ | gene-YER070W_AKU4011 | rna-NM_001178961.1_AKU4011 | cds-NP_010993.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:130385-133051:- | gene-YER070W_BG1 | rna-NM_001178961.1_BG1 | cds-NP_010993.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:302326-304992:+ | gene-YER070W_Bruggeman | rna-NM_001178961.1_Bruggeman | cds-NP_010993.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:296178-298844:+ | gene-YER070W_CAT1 | rna-NM_001178961.1_CAT1 | cds-NP_010993.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:292580-295246:+ | gene-YER070W_CBS1585 | rna-NM_001178961.1_CBS1585 | cds-NP_010993.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:294735-297401:+ | gene-YER070W_CBS436 | rna-NM_001178961.1_CBS436 | cds-NP_010993.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:292050-294716:+ | gene-YER070W_CBS6412 | rna-NM_001178961.1_CBS6412 | cds-NP_010993.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:298061-300727:+ | gene-YER070W_CBS6413 | rna-NM_001178961.1_CBS6413 | cds-NP_010993.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:296775-299441:+ | gene-YER070W_CENPK1137D | rna-NM_001178961.1_CENPK1137D | cds-NP_010993.1_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:293066-295732:+ | gene-YER070W_EthanolRed | rna-NM_001178961.1_EthanolRed | cds-NP_010993.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:293518-296184:+ | gene-YER070W_FaliES1 | rna-NM_001178961.1_FaliES1 | cds-NP_010993.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000153.1:8581-11247:+ | gene-YER070W_JAY291 | rna-NM_001178961.1_JAY291 | cds-NP_010993.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:297724-300390:+ | gene-YER070W_MUCL30387 | rna-NM_001178961.1_MUCL30387 | cds-NP_010993.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:293394-296060:+ | gene-YER070W_MUCL30388 | rna-NM_001178961.1_MUCL30388 | cds-NP_010993.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:291615-294281:+ | gene-YER070W_MUCL39482 | rna-NM_001178961.1_MUCL39482 | cds-NP_010993.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:298856-301522:+ | gene-YER070W_MUCL42920 | rna-NM_001178961.1_MUCL42920 | cds-NP_010993.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:298949-301615:+ | gene-YER070W_NCIM3186 | rna-NM_001178961.1_NCIM3186 | cds-NP_010993.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:296682-299348:+ | gene-YER070W_NCYC1407 | rna-NM_001178961.1_NCYC1407 | cds-NP_010993.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:307331-309997:+ | gene-YER070W_PE2H3 | rna-NM_001178961.1_PE2H3 | cds-NP_010993.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:297272-299938:+ | gene-YER070W_PE2H4 | rna-NM_001178961.1_PE2H4 | cds-NP_010993.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:298950-301616:+ | gene-YER070W_S288C | rna-NM_001178961.1_S288C | cds-NP_010993.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:8592-11258:+ | gene-YER070W_SA1 | rna-NM_001178961.1_SA1 | cds-NP_010993.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:294314-296980:+ | gene-YER070W_ThermosaccDry | rna-NM_001178961.1_ThermosaccDry | cds-NP_010993.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:295012-297678:+ | gene-YER070W_VR1 | rna-NM_001178961.1_VR1 | cds-NP_010993.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:291482-294148:+ | gene-YER070W_ZTW1 | rna-NM_001178961.1_ZTW1 | cds-NP_010993.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:294830-297496:+ | gene-YER070W_Sparadoxus | rna-NM_001178961.1_Sparadoxus | cds-NP_010993.1_Sparadoxus | 92.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |