Gene name: RFA3
Reference locus (S288C): YJL173C
Gene biotype: protein_coding
Description: Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): RFA1 (0.999); RFA2 (0.999); PRI2 (0.963); POL12 (0.962); POL32 (0.945); PRI1 (0.945); POL1 (0.942); POL3 (0.939); POL31 (0.926); RAD52 (0.891); RAD51 (0.844); MEC1 (0.823); CMR1 (0.814); RTT105 (0.808); RAD17 (0.802); DNA2 (0.792); RAD10 (0.785); MET18 (0.785); RAD2 (0.785); RAD1 (0.785)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:84555-84923:- | gene-YJL173C_AKU4011 | rna-NM_001181606.1_AKU4011 | cds-NP_012362.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000181.1:61889-62257:- | gene-YJL173C_BG1 | rna-NM_001181606.1_BG1 | cds-NP_012362.1_BG1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:96385-96753:- | gene-YJL173C_Bruggeman | rna-NM_001181606.1_Bruggeman | cds-NP_012362.1_Bruggeman | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:99854-100222:- | gene-YJL173C_CAT1 | rna-NM_001181606.1_CAT1 | cds-NP_012362.1_CAT1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:90190-90558:- | gene-YJL173C_CBS1585 | rna-NM_001181606.1_CBS1585 | cds-NP_012362.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:114950-115318:- | gene-YJL173C_CBS436 | rna-NM_001181606.1_CBS436 | cds-NP_012362.1_CBS436 | 98.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:86672-87040:- | gene-YJL173C_CBS6412 | rna-NM_001181606.1_CBS6412 | cds-NP_012362.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:87665-88033:- | gene-YJL173C_CBS6413 | rna-NM_001181606.1_CBS6413 | cds-NP_012362.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:78637-79005:- | gene-YJL173C_CENPK1137D | rna-NM_001181606.1_CENPK1137D | cds-NP_012362.1_CENPK1137D | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:88851-89219:- | gene-YJL173C_EthanolRed | rna-NM_001181606.1_EthanolRed | cds-NP_012362.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:94128-94496:- | gene-YJL173C_FaliES1 | rna-NM_001181606.1_FaliES1 | cds-NP_012362.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000164.1:24230-24598:+ | gene-YJL173C_JAY291 | rna-NM_001181606.1_JAY291 | cds-NP_012362.1_JAY291 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:98114-98482:- | gene-YJL173C_MUCL30387 | rna-NM_001181606.1_MUCL30387 | cds-NP_012362.1_MUCL30387 | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:94276-94644:- | gene-YJL173C_MUCL30388 | rna-NM_001181606.1_MUCL30388 | cds-NP_012362.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:88932-89300:- | gene-YJL173C_MUCL39482 | rna-NM_001181606.1_MUCL39482 | cds-NP_012362.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:93542-93910:- | gene-YJL173C_MUCL42920 | rna-NM_001181606.1_MUCL42920 | cds-NP_012362.1_MUCL42920 | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:96140-96508:- | gene-YJL173C_NCIM3186 | rna-NM_001181606.1_NCIM3186 | cds-NP_012362.1_NCIM3186 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:87543-87911:- | gene-YJL173C_NCYC1407 | rna-NM_001181606.1_NCYC1407 | cds-NP_012362.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:100256-100624:- | gene-YJL173C_PE2H3 | rna-NM_001181606.1_PE2H3 | cds-NP_012362.1_PE2H3 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:99895-100263:- | gene-YJL173C_PE2H4 | rna-NM_001181606.1_PE2H4 | cds-NP_012362.1_PE2H4 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:96161-96529:- | gene-YJL173C_S288C | rna-NM_001181606.1_S288C | cds-NP_012362.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000022.1:57341-57709:+ | gene-YJL173C_SA1 | rna-NM_001181606.1_SA1 | cds-NP_012362.1_SA1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:87322-87690:- | gene-YJL173C_ThermosaccDry | rna-NM_001181606.1_ThermosaccDry | cds-NP_012362.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:94206-94574:- | gene-YJL173C_VR1 | rna-NM_001181606.1_VR1 | cds-NP_012362.1_VR1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:74905-75273:- | gene-YJL173C_ZTW1 | rna-NM_001181606.1_ZTW1 | cds-NP_012362.1_ZTW1 | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:99301-99669:- | gene-YJL173C_Sparadoxus | rna-NM_001181606.1_Sparadoxus | cds-NP_012362.1_Sparadoxus | 91.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |