Gene name: RFA2
Reference locus (S288C): YNL312W
Gene biotype: protein_coding
Description: Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s
Top 10 interactors (score): RFA1 (0.999); RFA3 (0.999); RAD52 (0.999); PRI2 (0.998); MCM2 (0.998); POL12 (0.998); PRI1 (0.998); MEC1 (0.998); MCM5 (0.996); RAD14 (0.996); MCM4 (0.996); SGS1 (0.995); POL1 (0.992); CSM3 (0.992); MCM3 (0.99); RFC4 (0.989); RFC2 (0.988); MCM7 (0.985); POL2 (0.985); MCM6 (0.984)
Homologues (species, bitscore): RPA2 (Homo sapiens, 82.0); Rpa2 (Mus musculus, 77.0); rpa2 (Danio rerio, 68.9); rpa2 (Xenopus tropicalis, 76.3); RPA2 (Drosophila melanogaster, 66.6); RPA2 (Arabidopsis thaliana, 83.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:42089-43018:+ | gene-YNL312W_AKU4011 | rna-NM_001183150.1_AKU4011 | cds-NP_014087.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000074.1:47623-48552:- | gene-YNL312W_BG1 | rna-NM_001183150.1_BG1 | cds-NP_014087.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:51428-52357:+ | gene-YNL312W_Bruggeman | rna-NM_001183150.1_Bruggeman | cds-NP_014087.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:54043-54972:+ | gene-YNL312W_CAT1 | rna-NM_001183150.1_CAT1 | cds-NP_014087.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:42421-43350:+ | gene-YNL312W_CBS1585 | rna-NM_001183150.1_CBS1585 | cds-NP_014087.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:42913-43842:+ | gene-YNL312W_CBS436 | rna-NM_001183150.1_CBS436 | cds-NP_014087.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:39080-40009:+ | gene-YNL312W_CBS6412 | rna-NM_001183150.1_CBS6412 | cds-NP_014087.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:39269-40198:+ | gene-YNL312W_CBS6413 | rna-NM_001183150.1_CBS6413 | cds-NP_014087.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:42114-43043:+ | gene-YNL312W_CENPK1137D | rna-NM_001183150.1_CENPK1137D | cds-NP_014087.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:39111-40040:+ | gene-YNL312W_EthanolRed | rna-NM_001183150.1_EthanolRed | cds-NP_014087.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:40010-40939:+ | gene-YNL312W_FaliES1 | rna-NM_001183150.1_FaliES1 | cds-NP_014087.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000390.1:14578-15507:- | gene-YNL312W_JAY291 | rna-NM_001183150.1_JAY291 | cds-NP_014087.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:51683-52612:+ | gene-YNL312W_MUCL30387 | rna-NM_001183150.1_MUCL30387 | cds-NP_014087.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:44714-45643:+ | gene-YNL312W_MUCL30388 | rna-NM_001183150.1_MUCL30388 | cds-NP_014087.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:40057-40986:+ | gene-YNL312W_MUCL39482 | rna-NM_001183150.1_MUCL39482 | cds-NP_014087.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:41749-42678:+ | gene-YNL312W_MUCL42920 | rna-NM_001183150.1_MUCL42920 | cds-NP_014087.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:48256-49185:+ | gene-YNL312W_NCIM3186 | rna-NM_001183150.1_NCIM3186 | cds-NP_014087.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:41389-42318:+ | gene-YNL312W_NCYC1407 | rna-NM_001183150.1_NCYC1407 | cds-NP_014087.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:38591-39520:+ | gene-YNL312W_PE2H3 | rna-NM_001183150.1_PE2H3 | cds-NP_014087.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:37979-38908:+ | gene-YNL312W_PE2H4 | rna-NM_001183150.1_PE2H4 | cds-NP_014087.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:48287-49216:+ | gene-YNL312W_S288C | rna-NM_001183150.1_S288C | cds-NP_014087.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000052.1:48008-48937:- | gene-YNL312W_SA1 | rna-NM_001183150.1_SA1 | cds-NP_014087.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:40867-41796:+ | gene-YNL312W_ThermosaccDry | rna-NM_001183150.1_ThermosaccDry | cds-NP_014087.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:53406-54335:+ | gene-YNL312W_VR1 | rna-NM_001183150.1_VR1 | cds-NP_014087.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000029.1:32080-33010:+ | gene-YNL312W_ZTW1 | rna-NM_001183150.1_ZTW1 | cds-NP_014087.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:50069-50996:+ | gene-YNL312W_Sparadoxus | rna-NM_001183150.1_Sparadoxus | cds-NP_014087.1_Sparadoxus | 93.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |