Gene name: RFA1
Reference locus (S288C): YAR007C
Gene biotype: protein_coding
Description: Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; role in DNA catenation/decatenation pathway of chromosome disentangling; relocalizes to the cytosol in response to hypoxia
Top 10 interactors (score): SGS1 (0.999); MEC1 (0.999); MCM2 (0.999); RFA3 (0.999); RAD51 (0.999); POL30 (0.999); DNA2 (0.999); RAD52 (0.999); POL3 (0.999); RFA2 (0.999); RAD1 (0.999); POL1 (0.998); PRI2 (0.998); MPH1 (0.998); YKU70 (0.998); PRI1 (0.997); POL12 (0.997); POL31 (0.997); MCM6 (0.996); RAD9 (0.995)
Homologues (species, bitscore): RPA1 (Homo sapiens, 340.1); Rpa1 (Mus musculus, 331.6); rpa1 (Danio rerio, 342.0); rpa1 (Xenopus tropicalis, 324.7); RpA-70 (Drosophila melanogaster, 315.8); rpa-1 (Caenorhabditis elegans, 213.0); RPA1A (Arabidopsis thaliana, 313.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005295.1:142183-144048:- | gene-YAR007C_AKU4011 | rna-NM_001178211.1_AKU4011 | cds-NP_009404.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000103.1:4642-6507:- | gene-YAR007C_BG1 | rna-NM_001178211.1_BG1 | cds-NP_009404.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005503.1:156969-158834:- | gene-YAR007C_Bruggeman | rna-NM_001178211.1_Bruggeman | cds-NP_009404.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005519.1:143853-145686:- | gene-YAR007C_CAT1 | rna-NM_001178211.1_CAT1 | cds-NP_009404.1_CAT1 | 96.5 | 98.2 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005359.1:154881-156746:- | gene-YAR007C_CBS1585 | rna-NM_001178211.1_CBS1585 | cds-NP_009404.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005343.1:155195-157060:- | gene-YAR007C_CBS436 | rna-NM_001178211.1_CBS436 | cds-NP_009404.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:767625-769490:- | gene-YAR007C_CBS6412 | rna-NM_001178211.1_CBS6412 | cds-NP_009404.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005311.1:153149-155014:- | gene-YAR007C_CBS6413 | rna-NM_001178211.1_CBS6413 | cds-NP_009404.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001522.1:156660-158525:- | gene-YAR007C_CENPK1137D | rna-NM_001178211.1_CENPK1137D | cds-NP_009404.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005471.1:142739-144604:- | gene-YAR007C_EthanolRed | rna-NM_001178211.1_EthanolRed | cds-NP_009404.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005535.1:158400-160265:- | gene-YAR007C_FaliES1 | rna-NM_001178211.1_FaliES1 | cds-NP_009404.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000248.1:15769-17634:- | gene-YAR007C_JAY291 | rna-NM_001178211.1_JAY291 | cds-NP_009404.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005407.1:158736-160601:- | gene-YAR007C_MUCL30387 | rna-NM_001178211.1_MUCL30387 | cds-NP_009404.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005439.1:155387-157252:- | gene-YAR007C_MUCL30388 | rna-NM_001178211.1_MUCL30388 | cds-NP_009404.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005279.1:154137-156002:- | gene-YAR007C_MUCL39482 | rna-NM_001178211.1_MUCL39482 | cds-NP_009404.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005423.1:156568-158401:- | gene-YAR007C_MUCL42920 | rna-NM_001178211.1_MUCL42920 | cds-NP_009404.1_MUCL42920 | 96.5 | 98.2 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011810.1:156631-158496:- | gene-YAR007C_NCIM3186 | rna-NM_001178211.1_NCIM3186 | cds-NP_009404.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005263.1:141547-143412:- | gene-YAR007C_NCYC1407 | rna-NM_001178211.1_NCYC1407 | cds-NP_009404.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994140.1:143468-145333:- | gene-YAR007C_PE2H3 | rna-NM_001178211.1_PE2H3 | cds-NP_009404.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999872.1:143187-145052:- | gene-YAR007C_PE2H4 | rna-NM_001178211.1_PE2H4 | cds-NP_009404.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001133.9:156754-158619:- | gene-YAR007C_S288C | rna-NM_001178211.1_S288C | cds-NP_009404.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000100.1:15485-17350:- | gene-YAR007C_SA1 | rna-NM_001178211.1_SA1 | cds-NP_009404.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005487.1:157405-159270:- | gene-YAR007C_ThermosaccDry | rna-NM_001178211.1_ThermosaccDry | cds-NP_009404.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005455.1:161958-163823:- | gene-YAR007C_VR1 | rna-NM_001178211.1_VR1 | cds-NP_009404.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000002.1:129228-131093:- | gene-YAR007C_ZTW1 | rna-NM_001178211.1_ZTW1 | cds-NP_009404.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047487.1:146843-148708:- | gene-YAR007C_Sparadoxus | rna-NM_001178211.1_Sparadoxus | cds-NP_009404.1_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |