Gene name: RAD6
Reference locus (S288C): YGL058W
Gene biotype: protein_coding
Description: E2 ubiquitin-conjugating protein RAD6; Ubiquitin-conjugating enzyme (E2); involved in postreplication repair as a heterodimer with Rad18p, regulation of K63 polyubiquitination in response to oxidative stress, DSBR and checkpoint control as a heterodimer with Bre1p, ubiquitin-mediated N-end rule protein degradation as a heterodimer with Ubr1p, ERAD with Ubr1p in the absence of canonical ER membrane ligases, and Rpn4p turnover as part of proteasome homeostasis, in complex with Ubr2p and Mub1p
Top 10 interactors (score): BRE1 (0.999); RAD18 (0.999); UBR2 (0.999); UBR1 (0.999); UBA1 (0.999); REV3 (0.997); MMS2 (0.996); RAD52 (0.994); SRS2 (0.993); RAD5 (0.991); RAD51 (0.987); UBC13 (0.983); POL30 (0.982); HTB1 (0.975); HTB2 (0.973); MUB1 (0.969); SET1 (0.967); UBI4 (0.964); REV1 (0.963); RTF1 (0.958)
Homologues (species, bitscore): UBE2A (Homo sapiens, 234.6); Ube2a (Mus musculus, 234.6); ube2a (Danio rerio, 234.6); ube2b (Xenopus tropicalis, 235.3); Ubc6 (Drosophila melanogaster, 231.1); ubc-1 (Caenorhabditis elegans, 229.6); UBC2 (Arabidopsis thaliana, 223.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:396977-397492:+ | gene-YGL058W_AKU4011 | rna-NM_001180923.1_AKU4011 | cds-NP_011457.1_AKU4011 | 99.0 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:7897-8415:- | gene-YGL058W_BG1 | rna-NM_001180923.1_BG1 | cds-NP_011457.1_BG1 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:399454-399969:+ | gene-YGL058W_Bruggeman | rna-NM_001180923.1_Bruggeman | cds-NP_011457.1_Bruggeman | 99.4 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:396451-396966:+ | gene-YGL058W_CAT1 | rna-NM_001180923.1_CAT1 | cds-NP_011457.1_CAT1 | 99.0 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:400522-401037:+ | gene-YGL058W_CBS1585 | rna-NM_001180923.1_CBS1585 | cds-NP_011457.1_CBS1585 | 98.8 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:394660-395175:+ | gene-YGL058W_CBS436 | rna-NM_001180923.1_CBS436 | cds-NP_011457.1_CBS436 | 99.4 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:384681-385196:+ | gene-YGL058W_CBS6412 | rna-NM_001180923.1_CBS6412 | cds-NP_011457.1_CBS6412 | 98.8 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:394607-395122:+ | gene-YGL058W_CBS6413 | rna-NM_001180923.1_CBS6413 | cds-NP_011457.1_CBS6413 | 98.8 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:394173-394691:+ | gene-YGL058W_CENPK1137D | rna-NM_001180923.1_CENPK1137D | cds-NP_011457.1_CENPK1137D | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:386047-386562:+ | gene-YGL058W_EthanolRed | rna-NM_001180923.1_EthanolRed | cds-NP_011457.1_EthanolRed | 99.0 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:388609-389124:+ | gene-YGL058W_FaliES1 | rna-NM_001180923.1_FaliES1 | cds-NP_011457.1_FaliES1 | 99.0 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000144.1:7140-7655:- | gene-YGL058W_JAY291 | rna-NM_001180923.1_JAY291 | cds-NP_011457.1_JAY291 | 99.4 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:396650-397165:+ | gene-YGL058W_MUCL30387 | rna-NM_001180923.1_MUCL30387 | cds-NP_011457.1_MUCL30387 | 99.4 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:399698-400213:+ | gene-YGL058W_MUCL30388 | rna-NM_001180923.1_MUCL30388 | cds-NP_011457.1_MUCL30388 | 99.2 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:396830-397345:+ | gene-YGL058W_MUCL39482 | rna-NM_001180923.1_MUCL39482 | cds-NP_011457.1_MUCL39482 | 98.8 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:176763-177278:- | gene-YGL058W_MUCL42920 | rna-NM_001180923.1_MUCL42920 | cds-NP_011457.1_MUCL42920 | 99.4 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:393986-394504:+ | gene-YGL058W_NCIM3186 | rna-NM_001180923.1_NCIM3186 | cds-NP_011457.1_NCIM3186 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:388363-388878:+ | gene-YGL058W_NCYC1407 | rna-NM_001180923.1_NCYC1407 | cds-NP_011457.1_NCYC1407 | 98.8 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:390019-390534:+ | gene-YGL058W_PE2H3 | rna-NM_001180923.1_PE2H3 | cds-NP_011457.1_PE2H3 | 99.4 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:395069-395584:+ | gene-YGL058W_PE2H4 | rna-NM_001180923.1_PE2H4 | cds-NP_011457.1_PE2H4 | 99.4 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:393986-394504:+ | gene-YGL058W_S288C | rna-NM_001180923.1_S288C | cds-NP_011457.1_S288C | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000096.1:29154-29672:+ | gene-YGL058W_SA1 | rna-NM_001180923.1_SA1 | cds-NP_011457.1_SA1 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:388860-389375:+ | gene-YGL058W_ThermosaccDry | rna-NM_001180923.1_ThermosaccDry | cds-NP_011457.1_ThermosaccDry | 99.0 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:499245-499760:+ | gene-YGL058W_VR1 | rna-NM_001180923.1_VR1 | cds-NP_011457.1_VR1 | 99.4 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:386223-386738:+ | gene-YGL058W_ZTW1 | rna-NM_001180923.1_ZTW1 | cds-NP_011457.1_ZTW1 | 99.0 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:391848-392360:+ | gene-YGL058W_Sparadoxus | rna-NM_001180923.1_Sparadoxus | cds-NP_011457.1_Sparadoxus | 93.0 | 98.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |