Gene name: RAD53
Reference locus (S288C): YPL153C
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase RAD53; DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily
Top 10 interactors (score): TEL1 (0.999); MEC1 (0.999); RAD9 (0.999); DBF4 (0.999); MRC1 (0.999); ASF1 (0.999); CDC7 (0.999); CHK1 (0.999); SGS1 (0.998); MUS81 (0.997); SML1 (0.996); MIH1 (0.994); CDC5 (0.99); EXO1 (0.989); MCM4 (0.988); RAD24 (0.988); CDC45 (0.987); LCD1 (0.984); RAD51 (0.984); DUN1 (0.983)
Homologues (species, bitscore): CAMK1G (Homo sapiens, 219.5); Chek2 (Mus musculus, 219.9); camk1da (Danio rerio, 222.2); camk1 (Xenopus tropicalis, 218.4); CaMKII (Drosophila melanogaster, 191.8); cmk-1 (Caenorhabditis elegans, 199.9); CPK9 (Arabidopsis thaliana, 192.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:239382-241847:- | gene-YPL153C_AKU4011 | rna-NM_001183967.1_AKU4011 | cds-NP_015172.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:445070-447535:- | gene-YPL153C_BG1 | rna-NM_001183967.1_BG1 | cds-NP_015172.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:265375-267840:- | gene-YPL153C_Bruggeman | rna-NM_001183967.1_Bruggeman | cds-NP_015172.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:262059-264524:- | gene-YPL153C_CAT1 | rna-NM_001183967.1_CAT1 | cds-NP_015172.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:243445-245910:- | gene-YPL153C_CBS1585 | rna-NM_001183967.1_CBS1585 | cds-NP_015172.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:258122-260587:- | gene-YPL153C_CBS436 | rna-NM_001183967.1_CBS436 | cds-NP_015172.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:248123-250588:- | gene-YPL153C_CBS6412 | rna-NM_001183967.1_CBS6412 | cds-NP_015172.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:240085-242550:- | gene-YPL153C_CBS6413 | rna-NM_001183967.1_CBS6413 | cds-NP_015172.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:261629-264094:- | gene-YPL153C_CENPK1137D | rna-NM_001183967.1_CENPK1137D | cds-NP_015172.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:238072-240537:- | gene-YPL153C_EthanolRed | rna-NM_001183967.1_EthanolRed | cds-NP_015172.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:245664-248129:- | gene-YPL153C_FaliES1 | rna-NM_001183967.1_FaliES1 | cds-NP_015172.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:117721-120186:+ | gene-YPL153C_JAY291 | rna-NM_001183967.1_JAY291 | cds-NP_015172.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:256618-259083:- | gene-YPL153C_MUCL30387 | rna-NM_001183967.1_MUCL30387 | cds-NP_015172.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:254635-257100:- | gene-YPL153C_MUCL30388 | rna-NM_001183967.1_MUCL30388 | cds-NP_015172.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:236774-239239:- | gene-YPL153C_MUCL39482 | rna-NM_001183967.1_MUCL39482 | cds-NP_015172.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:293507-295972:- | gene-YPL153C_MUCL42920 | rna-NM_001183967.1_MUCL42920 | cds-NP_015172.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:261710-264175:- | gene-YPL153C_NCIM3186 | rna-NM_001183967.1_NCIM3186 | cds-NP_015172.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:243237-245702:- | gene-YPL153C_NCYC1407 | rna-NM_001183967.1_NCYC1407 | cds-NP_015172.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:250683-253148:- | gene-YPL153C_PE2H3 | rna-NM_001183967.1_PE2H3 | cds-NP_015172.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:250315-252780:- | gene-YPL153C_PE2H4 | rna-NM_001183967.1_PE2H4 | cds-NP_015172.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:261727-264192:- | gene-YPL153C_S288C | rna-NM_001183967.1_S288C | cds-NP_015172.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:109495-111960:+ | gene-YPL153C_SA1 | rna-NM_001183967.1_SA1 | cds-NP_015172.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:245462-247927:- | gene-YPL153C_ThermosaccDry | rna-NM_001183967.1_ThermosaccDry | cds-NP_015172.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:260443-262908:- | gene-YPL153C_VR1 | rna-NM_001183967.1_VR1 | cds-NP_015172.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:244790-247255:- | gene-YPL153C_ZTW1 | rna-NM_001183967.1_ZTW1 | cds-NP_015172.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:246451-248919:- | gene-YPL153C_Sparadoxus | rna-NM_001183967.1_Sparadoxus | cds-NP_015172.1_Sparadoxus | 90.4 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |