Gene name: PYC2
Reference locus (S288C): YBR218C
Gene biotype: protein_coding
Description: Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication
Top 10 interactors (score): PYC1 (0.999); CDC19 (0.997); PCK1 (0.995); MAE1 (0.988); MDH3 (0.981); MDH2 (0.979); CIT2 (0.975); PDA1 (0.971); CIT1 (0.971); MDH1 (0.965); PYK2 (0.964); PDB1 (0.962); AAT1 (0.962); AAT2 (0.957); FBP1 (0.957); CIT3 (0.956); DLD2 (0.951); PFK1 (0.937); MLS1 (0.935); CYB2 (0.929)
Homologues (species, bitscore): PC (Homo sapiens, 1249.2); Pcx (Mus musculus, 1256.5); pc (Danio rerio, 1269.2); pc.2 (Xenopus tropicalis, 1219.5); PCB (Drosophila melanogaster, 1271.9); pyc-1 (Caenorhabditis elegans, 1301.2); CAC2 (Arabidopsis thaliana, 370.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:643013-646555:- | gene-YBR218C_AKU4011 | rna-NM_001178566.1_AKU4011 | cds-NP_009777.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000066.1:13934-17476:- | gene-YBR218C_BG1 | rna-NM_001178566.1_BG1 | cds-NP_009777.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:644168-647710:- | gene-YBR218C_Bruggeman | rna-NM_001178566.1_Bruggeman | cds-NP_009777.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:647372-650914:- | gene-YBR218C_CAT1 | rna-NM_001178566.1_CAT1 | cds-NP_009777.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:634545-638087:- | gene-YBR218C_CBS1585 | rna-NM_001178566.1_CBS1585 | cds-NP_009777.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:640970-644512:- | gene-YBR218C_CBS436 | rna-NM_001178566.1_CBS436 | cds-NP_009777.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:729522-733064:- | gene-YBR218C_CBS6412 | rna-NM_001178566.1_CBS6412 | cds-NP_009777.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:640583-644125:- | gene-YBR218C_CBS6413 | rna-NM_001178566.1_CBS6413 | cds-NP_009777.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:652457-656030:- | gene-YBR218C_CENPK1137D | rna-NM_001178566.1_CENPK1137D | cds-NP_009777.1_CENPK1137D | 89.3 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:766258-769800:- | gene-YBR218C_EthanolRed | rna-NM_001178566.1_EthanolRed | cds-NP_009777.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:659365-662907:- | gene-YBR218C_FaliES1 | rna-NM_001178566.1_FaliES1 | cds-NP_009777.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000326.1:13737-15520:- | gene-YBR218C_JAY291 | rna-NM_001178566.1_JAY291 | cds-NP_009777.1_JAY291 | 50.1 | 50.3 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:646181-649723:- | gene-YBR218C_MUCL30387 | rna-NM_001178566.1_MUCL30387 | cds-NP_009777.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:663261-666803:- | gene-YBR218C_MUCL30388 | rna-NM_001178566.1_MUCL30388 | cds-NP_009777.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:632897-636439:- | gene-YBR218C_MUCL39482 | rna-NM_001178566.1_MUCL39482 | cds-NP_009777.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:642379-646281:- | gene-YBR218C_MUCL42920 | rna-NM_001178566.1_MUCL42920 | cds-NP_009777.1_MUCL42920 | 90.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:658504-662046:- | gene-YBR218C_NCIM3186 | rna-NM_001178566.1_NCIM3186 | cds-NP_009777.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:634759-638301:- | gene-YBR218C_NCYC1407 | rna-NM_001178566.1_NCYC1407 | cds-NP_009777.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:657875-661417:- | gene-YBR218C_PE2H3 | rna-NM_001178566.1_PE2H3 | cds-NP_009777.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:655551-659093:- | gene-YBR218C_PE2H4 | rna-NM_001178566.1_PE2H4 | cds-NP_009777.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:658707-662249:- | gene-YBR218C_S288C | rna-NM_001178566.1_S288C | cds-NP_009777.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000019.1:13831-17373:- | gene-YBR218C_SA1 | rna-NM_001178566.1_SA1 | cds-NP_009777.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:658375-661917:- | gene-YBR218C_ThermosaccDry | rna-NM_001178566.1_ThermosaccDry | cds-NP_009777.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:638547-642089:- | gene-YBR218C_VR1 | rna-NM_001178566.1_VR1 | cds-NP_009777.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:631242-634784:- | gene-YBR218C_ZTW1 | rna-NM_001178566.1_ZTW1 | cds-NP_009777.1_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:675219-678761:- | gene-YBR218C_Sparadoxus | rna-NM_001178566.1_Sparadoxus | cds-NP_009777.1_Sparadoxus | 93.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |