Gene name: PYC1
Reference locus (S288C): YGL062W
Gene biotype: protein_coding
Description: Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication
Top 10 interactors (score): PYC2 (0.999); PCK1 (0.995); CDC19 (0.994); CIT2 (0.987); PDB1 (0.978); PYK2 (0.972); CIT1 (0.971); AAT2 (0.969); MAE1 (0.969); AAT1 (0.967); MDH3 (0.965); MDH1 (0.963); MDH2 (0.961); PDA1 (0.958); FBP1 (0.957); DLD3 (0.956); CIT3 (0.956); DLD2 (0.951); MLS1 (0.94); PFK1 (0.937)
Homologues (species, bitscore): PC (Homo sapiens, 1256.1); Pcx (Mus musculus, 1263.4); pc (Danio rerio, 1273.8); pc.2 (Xenopus tropicalis, 1222.6); PCB (Drosophila melanogaster, 1276.9); pyc-1 (Caenorhabditis elegans, 1313.5); CAC2 (Arabidopsis thaliana, 379.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:388189-391725:+ | gene-YGL062W_AKU4011 | rna-NM_001180927.1_AKU4011 | cds-NP_011453.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:13668-17204:- | gene-YGL062W_BG1 | rna-NM_001180927.1_BG1 | cds-NP_011453.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:390666-394202:+ | gene-YGL062W_Bruggeman | rna-NM_001180927.1_Bruggeman | cds-NP_011453.1_Bruggeman | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:387661-391197:+ | gene-YGL062W_CAT1 | rna-NM_001180927.1_CAT1 | cds-NP_011453.1_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:391734-395270:+ | gene-YGL062W_CBS1585 | rna-NM_001180927.1_CBS1585 | cds-NP_011453.1_CBS1585 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:385871-389407:+ | gene-YGL062W_CBS436 | rna-NM_001180927.1_CBS436 | cds-NP_011453.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:375893-379429:+ | gene-YGL062W_CBS6412 | rna-NM_001180927.1_CBS6412 | cds-NP_011453.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:385819-389355:+ | gene-YGL062W_CBS6413 | rna-NM_001180927.1_CBS6413 | cds-NP_011453.1_CBS6413 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:385383-388919:+ | gene-YGL062W_CENPK1137D | rna-NM_001180927.1_CENPK1137D | cds-NP_011453.1_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:377259-380795:+ | gene-YGL062W_EthanolRed | rna-NM_001180927.1_EthanolRed | cds-NP_011453.1_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:379821-383357:+ | gene-YGL062W_FaliES1 | rna-NM_001180927.1_FaliES1 | cds-NP_011453.1_FaliES1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000144.1:12909-14545:- | gene-YGL062W_JAY291 | rna-NM_001180927.1_JAY291 | cds-NP_011453.1_JAY291 | 46.2 | 46.2 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:387862-391398:+ | gene-YGL062W_MUCL30387 | rna-NM_001180927.1_MUCL30387 | cds-NP_011453.1_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:390909-394445:+ | gene-YGL062W_MUCL30388 | rna-NM_001180927.1_MUCL30388 | cds-NP_011453.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:388042-391578:+ | gene-YGL062W_MUCL39482 | rna-NM_001180927.1_MUCL39482 | cds-NP_011453.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:182531-186067:- | gene-YGL062W_MUCL42920 | rna-NM_001180927.1_MUCL42920 | cds-NP_011453.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:385196-388732:+ | gene-YGL062W_NCIM3186 | rna-NM_001180927.1_NCIM3186 | cds-NP_011453.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:379575-383111:+ | gene-YGL062W_NCYC1407 | rna-NM_001180927.1_NCYC1407 | cds-NP_011453.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:381229-384765:+ | gene-YGL062W_PE2H3 | rna-NM_001180927.1_PE2H3 | cds-NP_011453.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:386279-389815:+ | gene-YGL062W_PE2H4 | rna-NM_001180927.1_PE2H4 | cds-NP_011453.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:385196-388732:+ | gene-YGL062W_S288C | rna-NM_001180927.1_S288C | cds-NP_011453.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000096.1:20364-23900:+ | gene-YGL062W_SA1 | rna-NM_001180927.1_SA1 | cds-NP_011453.1_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:380072-383608:+ | gene-YGL062W_ThermosaccDry | rna-NM_001180927.1_ThermosaccDry | cds-NP_011453.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:490456-493992:+ | gene-YGL062W_VR1 | rna-NM_001180927.1_VR1 | cds-NP_011453.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:377436-380972:+ | gene-YGL062W_ZTW1 | rna-NM_001180927.1_ZTW1 | cds-NP_011453.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:383057-386593:+ | gene-YGL062W_Sparadoxus | rna-NM_001180927.1_Sparadoxus | cds-NP_011453.1_Sparadoxus | 91.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |