Gene name: PUS4
Reference locus (S288C): YNL292W
Gene biotype: protein_coding
Description: Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
Top 10 interactors (score): NOP58 (0.998); NHP2 (0.998); NOP56 (0.998); SNU13 (0.996); NOP10 (0.995); PUS7 (0.993); PUS1 (0.99); RPF2 (0.988); MRT4 (0.987); ERB1 (0.984); NIP7 (0.983); YTM1 (0.981); PUS2 (0.978); NOP1 (0.977); EBP2 (0.976); NOP7 (0.976); DEG1 (0.975); NUG1 (0.971); GAR1 (0.971); UTP7 (0.97)
Homologues (species, bitscore): TRUB1 (Homo sapiens, 107.5); Trub1 (Mus musculus, 104.8); trub1 (Danio rerio, 103.6); trub1 (Xenopus tropicalis, 107.8); AT5G14460 (Arabidopsis thaliana, 97.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:76619-77830:+ | gene-YNL292W_AKU4011 | rna-NM_001183130.1_AKU4011 | cds-NP_014107.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000074.1:12814-14025:- | gene-YNL292W_BG1 | rna-NM_001183130.1_BG1 | cds-NP_014107.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:85965-87176:+ | gene-YNL292W_Bruggeman | rna-NM_001183130.1_Bruggeman | cds-NP_014107.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:88570-89781:+ | gene-YNL292W_CAT1 | rna-NM_001183130.1_CAT1 | cds-NP_014107.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:76950-78161:+ | gene-YNL292W_CBS1585 | rna-NM_001183130.1_CBS1585 | cds-NP_014107.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:77440-78651:+ | gene-YNL292W_CBS436 | rna-NM_001183130.1_CBS436 | cds-NP_014107.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:73607-74818:+ | gene-YNL292W_CBS6412 | rna-NM_001183130.1_CBS6412 | cds-NP_014107.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:73798-75009:+ | gene-YNL292W_CBS6413 | rna-NM_001183130.1_CBS6413 | cds-NP_014107.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:76639-77850:+ | gene-YNL292W_CENPK1137D | rna-NM_001183130.1_CENPK1137D | cds-NP_014107.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:73638-74849:+ | gene-YNL292W_EthanolRed | rna-NM_001183130.1_EthanolRed | cds-NP_014107.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:74537-75748:+ | gene-YNL292W_FaliES1 | rna-NM_001183130.1_FaliES1 | cds-NP_014107.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000171.1:12469-13680:- | gene-YNL292W_JAY291 | rna-NM_001183130.1_JAY291 | cds-NP_014107.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:86465-87676:+ | gene-YNL292W_MUCL30387 | rna-NM_001183130.1_MUCL30387 | cds-NP_014107.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:79245-80456:+ | gene-YNL292W_MUCL30388 | rna-NM_001183130.1_MUCL30388 | cds-NP_014107.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:74584-75795:+ | gene-YNL292W_MUCL39482 | rna-NM_001183130.1_MUCL39482 | cds-NP_014107.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:76276-77487:+ | gene-YNL292W_MUCL42920 | rna-NM_001183130.1_MUCL42920 | cds-NP_014107.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:82775-83986:+ | gene-YNL292W_NCIM3186 | rna-NM_001183130.1_NCIM3186 | cds-NP_014107.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:75916-77127:+ | gene-YNL292W_NCYC1407 | rna-NM_001183130.1_NCYC1407 | cds-NP_014107.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:73115-74326:+ | gene-YNL292W_PE2H3 | rna-NM_001183130.1_PE2H3 | cds-NP_014107.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:72503-73714:+ | gene-YNL292W_PE2H4 | rna-NM_001183130.1_PE2H4 | cds-NP_014107.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:82806-84017:+ | gene-YNL292W_S288C | rna-NM_001183130.1_S288C | cds-NP_014107.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000052.1:13200-14411:- | gene-YNL292W_SA1 | rna-NM_001183130.1_SA1 | cds-NP_014107.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:75394-76605:+ | gene-YNL292W_ThermosaccDry | rna-NM_001183130.1_ThermosaccDry | cds-NP_014107.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:87935-89146:+ | gene-YNL292W_VR1 | rna-NM_001183130.1_VR1 | cds-NP_014107.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000029.1:66605-67816:+ | gene-YNL292W_ZTW1 | rna-NM_001183130.1_ZTW1 | cds-NP_014107.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:84665-85876:+ | gene-YNL292W_Sparadoxus | rna-NM_001183130.1_Sparadoxus | cds-NP_014107.1_Sparadoxus | 89.9 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |