Gene name: PTC2
Reference locus (S288C): YER089C
Gene biotype: protein_coding
Description: Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
Top 10 interactors (score): PPH3 (0.98); RAD53 (0.947); HOG1 (0.938); PTP2 (0.921); NBP2 (0.9); PTC7 (0.898); PBS2 (0.896); PTP3 (0.893); PSY2 (0.859); PTP1 (0.837); IRE1 (0.824); PAA1 (0.802); PTC6 (0.795); DCR2 (0.784); PTC3 (0.782); SLT2 (0.754); MEC1 (0.717); STE11 (0.713); PTC1 (0.699); GLC7 (0.692)
Homologues (species, bitscore): PPM1B (Homo sapiens, 174.1); Ppm1b (Mus musculus, 173.7); ppm1bb (Danio rerio, 183.7); ppm1b (Xenopus tropicalis, 179.9); Ppm1 (Drosophila melanogaster, 236.5); T23F11.1 (Caenorhabditis elegans, 258.8); AT2G25070 (Arabidopsis thaliana, 211.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:329719-331113:- | gene-YER089C_AKU4011 | rna-NM_001178980.1_AKU4011 | cds-NP_011013.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:94723-96117:+ | gene-YER089C_BG1 | rna-NM_001178980.1_BG1 | cds-NP_011013.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:339280-340674:- | gene-YER089C_Bruggeman | rna-NM_001178980.1_Bruggeman | cds-NP_011013.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:333632-335026:- | gene-YER089C_CAT1 | rna-NM_001178980.1_CAT1 | cds-NP_011013.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:329584-330978:- | gene-YER089C_CBS1585 | rna-NM_001178980.1_CBS1585 | cds-NP_011013.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:331688-333082:- | gene-YER089C_CBS436 | rna-NM_001178980.1_CBS436 | cds-NP_011013.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:329040-330434:- | gene-YER089C_CBS6412 | rna-NM_001178980.1_CBS6412 | cds-NP_011013.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:335030-336424:- | gene-YER089C_CBS6413 | rna-NM_001178980.1_CBS6413 | cds-NP_011013.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:333859-335253:- | gene-YER089C_CENPK1137D | rna-NM_001178980.1_CENPK1137D | cds-NP_011013.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:330062-331456:- | gene-YER089C_EthanolRed | rna-NM_001178980.1_EthanolRed | cds-NP_011013.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:330507-331901:- | gene-YER089C_FaliES1 | rna-NM_001178980.1_FaliES1 | cds-NP_011013.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000153.1:45567-46961:- | gene-YER089C_JAY291 | rna-NM_001178980.1_JAY291 | cds-NP_011013.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:334676-336070:- | gene-YER089C_MUCL30387 | rna-NM_001178980.1_MUCL30387 | cds-NP_011013.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:330347-331741:- | gene-YER089C_MUCL30388 | rna-NM_001178980.1_MUCL30388 | cds-NP_011013.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:328608-330002:- | gene-YER089C_MUCL39482 | rna-NM_001178980.1_MUCL39482 | cds-NP_011013.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:335814-337208:- | gene-YER089C_MUCL42920 | rna-NM_001178980.1_MUCL42920 | cds-NP_011013.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:335945-337339:- | gene-YER089C_NCIM3186 | rna-NM_001178980.1_NCIM3186 | cds-NP_011013.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:333671-335065:- | gene-YER089C_NCYC1407 | rna-NM_001178980.1_NCYC1407 | cds-NP_011013.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:344321-345715:- | gene-YER089C_PE2H3 | rna-NM_001178980.1_PE2H3 | cds-NP_011013.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:334262-335656:- | gene-YER089C_PE2H4 | rna-NM_001178980.1_PE2H4 | cds-NP_011013.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:335946-337340:- | gene-YER089C_S288C | rna-NM_001178980.1_S288C | cds-NP_011013.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:45536-46930:- | gene-YER089C_SA1 | rna-NM_001178980.1_SA1 | cds-NP_011013.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:331304-332698:- | gene-YER089C_ThermosaccDry | rna-NM_001178980.1_ThermosaccDry | cds-NP_011013.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:331963-333357:- | gene-YER089C_VR1 | rna-NM_001178980.1_VR1 | cds-NP_011013.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:328465-329859:- | gene-YER089C_ZTW1 | rna-NM_001178980.1_ZTW1 | cds-NP_011013.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:331875-333269:- | gene-YER089C_Sparadoxus | rna-NM_001178980.1_Sparadoxus | cds-NP_011013.1_Sparadoxus | 92.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |