Gene name: PRS4
Reference locus (S288C): YBL068W
Gene biotype: protein_coding
Description: Ribose-phosphate pyrophosphokinase 4; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic; Belongs to the ribose-phosphate pyrophosphokinase family
Top 10 interactors (score): PRS2 (0.999); PRS1 (0.999); PRS5 (0.984); RKI1 (0.957); RBK1 (0.953); PRS3 (0.936); ADE4 (0.934); YSA1 (0.903); HIS1 (0.842); PRM15 (0.758); TKL1 (0.751); TKL2 (0.751); YTM1 (0.707); PGM2 (0.698); URA5 (0.673); URA7 (0.666); PGM1 (0.665); DOC1 (0.648); URA10 (0.643); ERB1 (0.629)
Homologues (species, bitscore): PRPS1 (Homo sapiens, 407.5); Prps1l3 (Mus musculus, 408.7); prps1b (Danio rerio, 405.2); prps1 (Xenopus tropicalis, 405.2); CG6767 (Drosophila melanogaster, 402.1); R151.2 (Caenorhabditis elegans, 405.2); AT2G35390 (Arabidopsis thaliana, 247.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:85994-86974:+ | gene-YBL068W_AKU4011 | rna-NM_001178308.2_AKU4011 | cds-NP_009485.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:76853-77833:+ | gene-YBL068W_BG1 | rna-NM_001178308.2_BG1 | cds-NP_009485.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:86609-87589:+ | gene-YBL068W_Bruggeman | rna-NM_001178308.2_Bruggeman | cds-NP_009485.3_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:89247-90227:+ | gene-YBL068W_CAT1 | rna-NM_001178308.2_CAT1 | cds-NP_009485.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:78561-79541:+ | gene-YBL068W_CBS1585 | rna-NM_001178308.2_CBS1585 | cds-NP_009485.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:87068-88048:+ | gene-YBL068W_CBS436 | rna-NM_001178308.2_CBS436 | cds-NP_009485.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:77067-78047:+ | gene-YBL068W_CBS6412 | rna-NM_001178308.2_CBS6412 | cds-NP_009485.3_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:84139-85119:+ | gene-YBL068W_CBS6413 | rna-NM_001178308.2_CBS6413 | cds-NP_009485.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:86173-87153:+ | gene-YBL068W_CENPK1137D | rna-NM_001178308.2_CENPK1137D | cds-NP_009485.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:99992-100972:+ | gene-YBL068W_EthanolRed | rna-NM_001178308.2_EthanolRed | cds-NP_009485.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:100845-101825:+ | gene-YBL068W_FaliES1 | rna-NM_001178308.2_FaliES1 | cds-NP_009485.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000072.1:3467-4447:+ | gene-YBL068W_JAY291 | rna-NM_001178308.2_JAY291 | cds-NP_009485.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:85983-86963:+ | gene-YBL068W_MUCL30387 | rna-NM_001178308.2_MUCL30387 | cds-NP_009485.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:87262-88242:+ | gene-YBL068W_MUCL30388 | rna-NM_001178308.2_MUCL30388 | cds-NP_009485.3_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:78742-79722:+ | gene-YBL068W_MUCL39482 | rna-NM_001178308.2_MUCL39482 | cds-NP_009485.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:85578-86558:+ | gene-YBL068W_MUCL42920 | rna-NM_001178308.2_MUCL42920 | cds-NP_009485.3_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:92211-93191:+ | gene-YBL068W_NCIM3186 | rna-NM_001178308.2_NCIM3186 | cds-NP_009485.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:79884-80864:+ | gene-YBL068W_NCYC1407 | rna-NM_001178308.2_NCYC1407 | cds-NP_009485.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:86142-87122:+ | gene-YBL068W_PE2H3 | rna-NM_001178308.2_PE2H3 | cds-NP_009485.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:83786-84766:+ | gene-YBL068W_PE2H4 | rna-NM_001178308.2_PE2H4 | cds-NP_009485.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:92414-93394:+ | gene-YBL068W_S288C | rna-NM_001178308.2_S288C | cds-NP_009485.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000004.1:76521-77501:+ | gene-YBL068W_SA1 | rna-NM_001178308.2_SA1 | cds-NP_009485.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:100806-101786:+ | gene-YBL068W_ThermosaccDry | rna-NM_001178308.2_ThermosaccDry | cds-NP_009485.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:82974-83954:+ | gene-YBL068W_VR1 | rna-NM_001178308.2_VR1 | cds-NP_009485.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:77524-78504:+ | gene-YBL068W_ZTW1 | rna-NM_001178308.2_ZTW1 | cds-NP_009485.3_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:112204-113184:+ | gene-YBL068W_Sparadoxus | rna-NM_001178308.2_Sparadoxus | cds-NP_009485.3_Sparadoxus | 93.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |