Gene name: PRS2
Reference locus (S288C): YER099C
Gene biotype: protein_coding
Description: Ribose-phosphate pyrophosphokinase 2; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication
Top 10 interactors (score): PRS4 (0.999); PRS1 (0.999); PRS5 (0.979); RBK1 (0.953); ADE4 (0.951); RKI1 (0.944); HIS1 (0.917); PRS3 (0.903); YSA1 (0.903); URA3 (0.868); HIS3 (0.819); TRP1 (0.769); TKL1 (0.76); PRM15 (0.758); TKL2 (0.751); LEU2 (0.745); RPE1 (0.69); PGM1 (0.665); PGM2 (0.665); URA10 (0.655)
Homologues (species, bitscore): PRPS1 (Homo sapiens, 397.5); Prps2 (Mus musculus, 399.4); prps1a (Danio rerio, 393.7); prps1 (Xenopus tropicalis, 394.0); CG6767 (Drosophila melanogaster, 385.2); R151.2 (Caenorhabditis elegans, 391.3); AT2G35390 (Arabidopsis thaliana, 238.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:351490-352446:- | gene-YER099C_AKU4011 | rna-NM_001178990.3_AKU4011 | cds-NP_011025.3_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:72664-73620:+ | gene-YER099C_BG1 | rna-NM_001178990.3_BG1 | cds-NP_011025.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:361964-362920:- | gene-YER099C_Bruggeman | rna-NM_001178990.3_Bruggeman | cds-NP_011025.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:356255-357211:- | gene-YER099C_CAT1 | rna-NM_001178990.3_CAT1 | cds-NP_011025.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:351355-352311:- | gene-YER099C_CBS1585 | rna-NM_001178990.3_CBS1585 | cds-NP_011025.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:353847-354803:- | gene-YER099C_CBS436 | rna-NM_001178990.3_CBS436 | cds-NP_011025.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:350811-351767:- | gene-YER099C_CBS6412 | rna-NM_001178990.3_CBS6412 | cds-NP_011025.3_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:356801-357757:- | gene-YER099C_CBS6413 | rna-NM_001178990.3_CBS6413 | cds-NP_011025.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:355878-356834:- | gene-YER099C_CENPK1137D | rna-NM_001178990.3_CENPK1137D | cds-NP_011025.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:351832-352788:- | gene-YER099C_EthanolRed | rna-NM_001178990.3_EthanolRed | cds-NP_011025.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:352277-353233:- | gene-YER099C_FaliES1 | rna-NM_001178990.3_FaliES1 | cds-NP_011025.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000356.1:4219-5175:+ | gene-YER099C_JAY291 | rna-NM_001178990.3_JAY291 | cds-NP_011025.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:357844-358800:- | gene-YER099C_MUCL30387 | rna-NM_001178990.3_MUCL30387 | cds-NP_011025.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:353389-354345:- | gene-YER099C_MUCL30388 | rna-NM_001178990.3_MUCL30388 | cds-NP_011025.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:350379-351335:- | gene-YER099C_MUCL39482 | rna-NM_001178990.3_MUCL39482 | cds-NP_011025.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:358880-359836:- | gene-YER099C_MUCL42920 | rna-NM_001178990.3_MUCL42920 | cds-NP_011025.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:358104-359060:- | gene-YER099C_NCIM3186 | rna-NM_001178990.3_NCIM3186 | cds-NP_011025.3_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:355442-356398:- | gene-YER099C_NCYC1407 | rna-NM_001178990.3_NCYC1407 | cds-NP_011025.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:366480-367436:- | gene-YER099C_PE2H3 | rna-NM_001178990.3_PE2H3 | cds-NP_011025.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:356421-357377:- | gene-YER099C_PE2H4 | rna-NM_001178990.3_PE2H4 | cds-NP_011025.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:358105-359061:- | gene-YER099C_S288C | rna-NM_001178990.3_S288C | cds-NP_011025.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000023.1:67724-68680:- | gene-YER099C_SA1 | rna-NM_001178990.3_SA1 | cds-NP_011025.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:353074-354030:- | gene-YER099C_ThermosaccDry | rna-NM_001178990.3_ThermosaccDry | cds-NP_011025.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:354122-355078:- | gene-YER099C_VR1 | rna-NM_001178990.3_VR1 | cds-NP_011025.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:350242-351198:- | gene-YER099C_ZTW1 | rna-NM_001178990.3_ZTW1 | cds-NP_011025.3_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:354137-355093:- | gene-YER099C_Sparadoxus | rna-NM_001178990.3_Sparadoxus | cds-NP_011025.3_Sparadoxus | 91.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |