Gene name: PRS1
Reference locus (S288C): YKL181W
Gene biotype: protein_coding
Description: Ribose-phosphate pyrophosphokinase 1; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease; Belongs to the ribose-phosphate pyrophosphokinase family
Top 10 interactors (score): PRS4 (0.999); PRS2 (0.999); PRS3 (0.99); PRS5 (0.982); RKI1 (0.977); RBK1 (0.95); ADE4 (0.937); GUA1 (0.933); YSA1 (0.903); BET2 (0.896); BRX1 (0.885); ELC1 (0.874); HIS1 (0.849); RRB1 (0.813); PGM2 (0.772); PRM15 (0.758); AAH1 (0.737); RPF2 (0.737); TKL1 (0.736); TKL2 (0.719)
Homologues (species, bitscore): PRPS1 (Homo sapiens, 275.4); Prps1l3 (Mus musculus, 276.2); prps1a (Danio rerio, 276.2); prps1 (Xenopus tropicalis, 271.2); CG6767 (Drosophila melanogaster, 272.3); R151.2 (Caenorhabditis elegans, 282.0); AT2G35390 (Arabidopsis thaliana, 174.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:94171-95454:+ | gene-YKL181W_AKU4011 | rna-NM_001179747.1_AKU4011 | cds-NP_012740.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:70698-71981:+ | gene-YKL181W_BG1 | rna-NM_001179747.1_BG1 | cds-NP_012740.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:111559-112842:+ | gene-YKL181W_Bruggeman | rna-NM_001179747.1_Bruggeman | cds-NP_012740.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:106516-107799:+ | gene-YKL181W_CAT1 | rna-NM_001179747.1_CAT1 | cds-NP_012740.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:106153-107436:+ | gene-YKL181W_CBS1585 | rna-NM_001179747.1_CBS1585 | cds-NP_012740.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:104912-106195:+ | gene-YKL181W_CBS436 | rna-NM_001179747.1_CBS436 | cds-NP_012740.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:91743-93026:+ | gene-YKL181W_CBS6412 | rna-NM_001179747.1_CBS6412 | cds-NP_012740.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:106871-108154:+ | gene-YKL181W_CBS6413 | rna-NM_001179747.1_CBS6413 | cds-NP_012740.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:107142-108425:+ | gene-YKL181W_CENPK1137D | rna-NM_001179747.1_CENPK1137D | cds-NP_012740.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:105057-106340:+ | gene-YKL181W_EthanolRed | rna-NM_001179747.1_EthanolRed | cds-NP_012740.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:105758-107041:+ | gene-YKL181W_FaliES1 | rna-NM_001179747.1_FaliES1 | cds-NP_012740.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000006.2:104741-106024:+ | gene-YKL181W_JAY291 | rna-NM_001179747.1_JAY291 | cds-NP_012740.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:113859-115142:+ | gene-YKL181W_MUCL30387 | rna-NM_001179747.1_MUCL30387 | cds-NP_012740.1_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:108203-109486:+ | gene-YKL181W_MUCL30388 | rna-NM_001179747.1_MUCL30388 | cds-NP_012740.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:106210-107493:+ | gene-YKL181W_MUCL39482 | rna-NM_001179747.1_MUCL39482 | cds-NP_012740.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:110542-111825:+ | gene-YKL181W_MUCL42920 | rna-NM_001179747.1_MUCL42920 | cds-NP_012740.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:107305-108588:+ | gene-YKL181W_NCIM3186 | rna-NM_001179747.1_NCIM3186 | cds-NP_012740.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:106234-107517:+ | gene-YKL181W_NCYC1407 | rna-NM_001179747.1_NCYC1407 | cds-NP_012740.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:113285-114568:+ | gene-YKL181W_PE2H3 | rna-NM_001179747.1_PE2H3 | cds-NP_012740.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:109579-110862:+ | gene-YKL181W_PE2H4 | rna-NM_001179747.1_PE2H4 | cds-NP_012740.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:107316-108599:+ | gene-YKL181W_S288C | rna-NM_001179747.1_S288C | cds-NP_012740.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:23518-24801:+ | gene-YKL181W_SA1 | rna-NM_001179747.1_SA1 | cds-NP_012740.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:106458-107741:+ | gene-YKL181W_ThermosaccDry | rna-NM_001179747.1_ThermosaccDry | cds-NP_012740.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:104990-106273:+ | gene-YKL181W_VR1 | rna-NM_001179747.1_VR1 | cds-NP_012740.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:104861-106144:+ | gene-YKL181W_ZTW1 | rna-NM_001179747.1_ZTW1 | cds-NP_012740.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:119404-120687:+ | gene-YKL181W_Sparadoxus | rna-NM_001179747.1_Sparadoxus | cds-NP_012740.1_Sparadoxus | 93.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |