Gene name: PRP8
Reference locus (S288C): YHR165C
Gene biotype: protein_coding
Description: Pre-mRNA-splicing factor 8; Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer
Top 10 interactors (score): PRP19 (0.999); AAR2 (0.999); LEA1 (0.999); SMX3 (0.999); CWC2 (0.999); SMX2 (0.999); SNU114 (0.999); PRP43 (0.999); RSE1 (0.999); LSM8 (0.999); LSM2 (0.999); BRR2 (0.999); CDC40 (0.999); CEF1 (0.999); SMD2 (0.999); PRP28 (0.999); SNU66 (0.999); HSH155 (0.999); SMD3 (0.999); SMB1 (0.999)
Homologues (species, bitscore): PRPF8 (Homo sapiens, 3063.5); Prpf8 (Mus musculus, 3060.8); prpf8 (Danio rerio, 3075.0); prpf8 (Xenopus tropicalis, 3062.7); Prp8 (Drosophila melanogaster, 3052.7); prp-8 (Caenorhabditis elegans, 3011.9); PRP8A (Arabidopsis thaliana, 3076.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:416800-424041:- | gene-YHR165C_AKU4011 | rna-NM_001179296.1_AKU4011 | cds-NP_012035.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000141.1:93697-100938:+ | gene-YHR165C_BG1 | rna-NM_001179296.1_BG1 | cds-NP_012035.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:424041-431282:- | gene-YHR165C_Bruggeman | rna-NM_001179296.1_Bruggeman | cds-NP_012035.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:419446-426687:- | gene-YHR165C_CAT1 | rna-NM_001179296.1_CAT1 | cds-NP_012035.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:416257-423498:- | gene-YHR165C_CBS1585 | rna-NM_001179296.1_CBS1585 | cds-NP_012035.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:413699-420940:- | gene-YHR165C_CBS436 | rna-NM_001179296.1_CBS436 | cds-NP_012035.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005334.1:416710-423951:- | gene-YHR165C_CBS6412 | rna-NM_001179296.1_CBS6412 | cds-NP_012035.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:417137-424378:- | gene-YHR165C_CBS6413 | rna-NM_001179296.1_CBS6413 | cds-NP_012035.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:422879-430120:- | gene-YHR165C_CENPK1137D | rna-NM_001179296.1_CENPK1137D | cds-NP_012035.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:475351-482592:- | gene-YHR165C_EthanolRed | rna-NM_001179296.1_EthanolRed | cds-NP_012035.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:417794-425035:- | gene-YHR165C_FaliES1 | rna-NM_001179296.1_FaliES1 | cds-NP_012035.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000017.1:14807-22048:+ | gene-YHR165C_JAY291 | rna-NM_001179296.1_JAY291 | cds-NP_012035.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:425112-432353:- | gene-YHR165C_MUCL30387 | rna-NM_001179296.1_MUCL30387 | cds-NP_012035.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:424551-431792:- | gene-YHR165C_MUCL30388 | rna-NM_001179296.1_MUCL30388 | cds-NP_012035.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:416168-423409:- | gene-YHR165C_MUCL39482 | rna-NM_001179296.1_MUCL39482 | cds-NP_012035.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:422774-430015:- | gene-YHR165C_MUCL42920 | rna-NM_001179296.1_MUCL42920 | cds-NP_012035.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:429589-436830:- | gene-YHR165C_NCIM3186 | rna-NM_001179296.1_NCIM3186 | cds-NP_012035.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005270.1:418626-425867:- | gene-YHR165C_NCYC1407 | rna-NM_001179296.1_NCYC1407 | cds-NP_012035.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:417768-425009:- | gene-YHR165C_PE2H3 | rna-NM_001179296.1_PE2H3 | cds-NP_012035.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:425195-432436:- | gene-YHR165C_PE2H4 | rna-NM_001179296.1_PE2H4 | cds-NP_012035.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:429707-436948:- | gene-YHR165C_S288C | rna-NM_001179296.1_S288C | cds-NP_012035.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000070.1:14868-22109:+ | gene-YHR165C_SA1 | rna-NM_001179296.1_SA1 | cds-NP_012035.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:418877-426118:- | gene-YHR165C_ThermosaccDry | rna-NM_001179296.1_ThermosaccDry | cds-NP_012035.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:426694-433935:- | gene-YHR165C_VR1 | rna-NM_001179296.1_VR1 | cds-NP_012035.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:409117-416358:- | gene-YHR165C_ZTW1 | rna-NM_001179296.1_ZTW1 | cds-NP_012035.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:415232-422467:- | gene-YHR165C_Sparadoxus | rna-NM_001179296.1_Sparadoxus | cds-NP_012035.1_Sparadoxus | 90.8 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |