Gene name: PRO1
Reference locus (S288C): YDR300C
Gene biotype: protein_coding
Description: Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family
Top 10 interactors (score): PRO2 (0.999); CAR2 (0.996); PUT2 (0.989); PRO3 (0.987); PUT1 (0.941); SNO1 (0.904); SNZ1 (0.9); YHR033W (0.802); ARG5,6 (0.788); GCN4 (0.786); TRP5 (0.766); CAC2 (0.712); CAR1 (0.69); XKS1 (0.641); UBP3 (0.624); HIS4 (0.611); CPA1 (0.599); IST1 (0.598); NTH1 (0.593); UGA2 (0.581)
Homologues (species, bitscore): ALDH18A1 (Homo sapiens, 107.1); Aldh18a1 (Mus musculus, 108.2); aldh18a1 (Danio rerio, 110.9); aldh18a1 (Xenopus tropicalis, 105.9); CG7470 (Drosophila melanogaster, 120.2); alh-13 (Caenorhabditis elegans, 130.2); P5CS2 (Arabidopsis thaliana, 114.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1013517-1014803:- | gene-YDR300C_AKU4011 | rna-NM_001180608.3_AKU4011 | cds-NP_010586.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:116772-118058:+ | gene-YDR300C_BG1 | rna-NM_001180608.3_BG1 | cds-NP_010586.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1040784-1042070:- | gene-YDR300C_Bruggeman | rna-NM_001180608.3_Bruggeman | cds-NP_010586.3_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1027782-1029068:- | gene-YDR300C_CAT1 | rna-NM_001180608.3_CAT1 | cds-NP_010586.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1007962-1009248:- | gene-YDR300C_CBS1585 | rna-NM_001180608.3_CBS1585 | cds-NP_010586.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1026333-1027619:- | gene-YDR300C_CBS436 | rna-NM_001180608.3_CBS436 | cds-NP_010586.3_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1004644-1005930:- | gene-YDR300C_CBS6412 | rna-NM_001180608.3_CBS6412 | cds-NP_010586.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1025882-1027168:- | gene-YDR300C_CBS6413 | rna-NM_001180608.3_CBS6413 | cds-NP_010586.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1060147-1061433:- | gene-YDR300C_CENPK1137D | rna-NM_001180608.3_CENPK1137D | cds-NP_010586.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1011872-1013158:- | gene-YDR300C_EthanolRed | rna-NM_001180608.3_EthanolRed | cds-NP_010586.3_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1020274-1021560:- | gene-YDR300C_FaliES1 | rna-NM_001180608.3_FaliES1 | cds-NP_010586.3_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000130.1:38067-39353:- | gene-YDR300C_JAY291 | rna-NM_001180608.3_JAY291 | cds-NP_010586.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1026270-1027556:- | gene-YDR300C_MUCL30387 | rna-NM_001180608.3_MUCL30387 | cds-NP_010586.3_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1013366-1014652:- | gene-YDR300C_MUCL30388 | rna-NM_001180608.3_MUCL30388 | cds-NP_010586.3_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:999768-1001054:- | gene-YDR300C_MUCL39482 | rna-NM_001180608.3_MUCL39482 | cds-NP_010586.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:939735-941021:- | gene-YDR300C_MUCL42920 | rna-NM_001180608.3_MUCL42920 | cds-NP_010586.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1061428-1062714:- | gene-YDR300C_NCIM3186 | rna-NM_001180608.3_NCIM3186 | cds-NP_010586.3_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1013061-1014347:- | gene-YDR300C_NCYC1407 | rna-NM_001180608.3_NCYC1407 | cds-NP_010586.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1024040-1025326:- | gene-YDR300C_PE2H3 | rna-NM_001180608.3_PE2H3 | cds-NP_010586.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1029625-1030911:- | gene-YDR300C_PE2H4 | rna-NM_001180608.3_PE2H4 | cds-NP_010586.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1061505-1062791:- | gene-YDR300C_S288C | rna-NM_001180608.3_S288C | cds-NP_010586.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000025.1:38240-39526:- | gene-YDR300C_SA1 | rna-NM_001180608.3_SA1 | cds-NP_010586.3_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1024547-1025833:- | gene-YDR300C_ThermosaccDry | rna-NM_001180608.3_ThermosaccDry | cds-NP_010586.3_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1040459-1041745:- | gene-YDR300C_VR1 | rna-NM_001180608.3_VR1 | cds-NP_010586.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:68662-69948:- | gene-YDR300C_ZTW1 | rna-NM_001180608.3_ZTW1 | cds-NP_010586.3_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1020092-1021378:- | gene-YDR300C_Sparadoxus | rna-NM_001180608.3_Sparadoxus | cds-NP_010586.3_Sparadoxus | 90.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |