Gene name: PRB1
Reference locus (S288C): YEL060C
Gene biotype: protein_coding
Description: Cerevisin; Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog, YSP3, that arose from the whole genome duplication
Top 10 interactors (score): PEP4 (0.991); TFS1 (0.983); PRC1 (0.948); YHR138C (0.894); YPS1 (0.877); PBI2 (0.859); AMS1 (0.859); YSP3 (0.807); CPS1 (0.806); MSC1 (0.794); LEU2 (0.78); ATG13 (0.776); HIS3 (0.776); ICP55 (0.771); MKC7 (0.766); ATG8 (0.766); SDS24 (0.766); URA3 (0.764); APE1 (0.759); KEX2 (0.753)
Homologues (species, bitscore): PCSK9 (Homo sapiens, 160.2); Pcsk9 (Mus musculus, 154.1); pcsk9 (Danio rerio, 146.7); pcsk9 (Xenopus tropicalis, 153.7); S1P (Drosophila melanogaster, 55.5); S1P (Arabidopsis thaliana, 59.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:34453-36360:- | gene-YEL060C_AKU4011 | rna-NM_001178875.1_AKU4011 | cds-NP_010854.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000075.1:44157-46064:+ | gene-YEL060C_BG1 | rna-NM_001178875.1_BG1 | cds-NP_010854.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:37960-39867:- | gene-YEL060C_Bruggeman | rna-NM_001178875.1_Bruggeman | cds-NP_010854.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:36394-38301:- | gene-YEL060C_CAT1 | rna-NM_001178875.1_CAT1 | cds-NP_010854.1_CAT1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:34396-36303:- | gene-YEL060C_CBS1585 | rna-NM_001178875.1_CBS1585 | cds-NP_010854.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:35452-37359:- | gene-YEL060C_CBS436 | rna-NM_001178875.1_CBS436 | cds-NP_010854.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:34648-36555:- | gene-YEL060C_CBS6412 | rna-NM_001178875.1_CBS6412 | cds-NP_010854.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:39294-41201:- | gene-YEL060C_CBS6413 | rna-NM_001178875.1_CBS6413 | cds-NP_010854.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:37883-39790:- | gene-YEL060C_CENPK1137D | rna-NM_001178875.1_CENPK1137D | cds-NP_010854.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:34211-36118:- | gene-YEL060C_EthanolRed | rna-NM_001178875.1_EthanolRed | cds-NP_010854.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:34474-36381:- | gene-YEL060C_FaliES1 | rna-NM_001178875.1_FaliES1 | cds-NP_010854.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000427.1:21688-23595:+ | gene-YEL060C_JAY291 | rna-NM_001178875.1_JAY291 | cds-NP_010854.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:38401-40308:- | gene-YEL060C_MUCL30387 | rna-NM_001178875.1_MUCL30387 | cds-NP_010854.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:34511-36418:- | gene-YEL060C_MUCL30388 | rna-NM_001178875.1_MUCL30388 | cds-NP_010854.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:33763-35670:- | gene-YEL060C_MUCL39482 | rna-NM_001178875.1_MUCL39482 | cds-NP_010854.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:38394-40301:- | gene-YEL060C_MUCL42920 | rna-NM_001178875.1_MUCL42920 | cds-NP_010854.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:40045-41952:- | gene-YEL060C_NCIM3186 | rna-NM_001178875.1_NCIM3186 | cds-NP_010854.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:38862-40769:- | gene-YEL060C_NCYC1407 | rna-NM_001178875.1_NCYC1407 | cds-NP_010854.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:42858-44765:- | gene-YEL060C_PE2H3 | rna-NM_001178875.1_PE2H3 | cds-NP_010854.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:38783-40690:- | gene-YEL060C_PE2H4 | rna-NM_001178875.1_PE2H4 | cds-NP_010854.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:40046-41953:- | gene-YEL060C_S288C | rna-NM_001178875.1_S288C | cds-NP_010854.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000053.1:44954-46861:+ | gene-YEL060C_SA1 | rna-NM_001178875.1_SA1 | cds-NP_010854.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:34874-36781:- | gene-YEL060C_ThermosaccDry | rna-NM_001178875.1_ThermosaccDry | cds-NP_010854.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:34075-35982:- | gene-YEL060C_VR1 | rna-NM_001178875.1_VR1 | cds-NP_010854.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:33811-35718:- | gene-YEL060C_ZTW1 | rna-NM_001178875.1_ZTW1 | cds-NP_010854.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:38188-40071:- | gene-YEL060C_Sparadoxus | rna-NM_001178875.1_Sparadoxus | cds-NP_010854.1_Sparadoxus | 88.0 | 97.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |