Gene name: PPN1
Reference locus (S288C): YDR452W
Gene biotype: protein_coding
Description: Endopolyphosphatase; Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
Top 10 interactors (score): PPX1 (0.97); DDP1 (0.869); VAM6 (0.868); YNL217W (0.858); CPS1 (0.85); SNA3 (0.779); RSP5 (0.757); TUL1 (0.749); VTC4 (0.746); SMF1 (0.745); ISC1 (0.724); TRE1 (0.718); VTC3 (0.717); PHO81 (0.715); PHO12 (0.711); BSD2 (0.698); PHO11 (0.697); VTC1 (0.694); VTC2 (0.693); PHO84 (0.692)
Homologues (species, bitscore): SMPDL3B (Homo sapiens, 98.2); Smpdl3b (Mus musculus, 94.0); LOC564392 (Danio rerio, 92.8); smpdl3a (Xenopus tropicalis, 79.3); CG3376 (Drosophila melanogaster, 92.8); asm-2 (Caenorhabditis elegans, 64.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1302777-1304801:+ | gene-YDR452W_AKU4011 | rna-NM_001180760.3_AKU4011 | cds-NP_010740.3_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:181142-183166:+ | gene-YDR452W_BG1 | rna-NM_001180760.3_BG1 | cds-NP_010740.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1334227-1336239:+ | gene-YDR452W_Bruggeman | rna-NM_001180760.3_Bruggeman | cds-NP_010740.3_Bruggeman | 99.1 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1311365-1313389:+ | gene-YDR452W_CAT1 | rna-NM_001180760.3_CAT1 | cds-NP_010740.3_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1297083-1299107:+ | gene-YDR452W_CBS1585 | rna-NM_001180760.3_CBS1585 | cds-NP_010740.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1316463-1318487:+ | gene-YDR452W_CBS436 | rna-NM_001180760.3_CBS436 | cds-NP_010740.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1292724-1294736:+ | gene-YDR452W_CBS6412 | rna-NM_001180760.3_CBS6412 | cds-NP_010740.3_CBS6412 | 98.9 | 99.4 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1315723-1317747:+ | gene-YDR452W_CBS6413 | rna-NM_001180760.3_CBS6413 | cds-NP_010740.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1361552-1363576:+ | gene-YDR452W_CENPK1137D | rna-NM_001180760.3_CENPK1137D | cds-NP_010740.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1306145-1308157:+ | gene-YDR452W_EthanolRed | rna-NM_001180760.3_EthanolRed | cds-NP_010740.3_EthanolRed | 99.0 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1309698-1311710:+ | gene-YDR452W_FaliES1 | rna-NM_001180760.3_FaliES1 | cds-NP_010740.3_FaliES1 | 99.0 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000026.1:7951-9975:+ | gene-YDR452W_JAY291 | rna-NM_001180760.3_JAY291 | cds-NP_010740.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1316705-1318729:+ | gene-YDR452W_MUCL30387 | rna-NM_001180760.3_MUCL30387 | cds-NP_010740.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1298737-1300749:+ | gene-YDR452W_MUCL30388 | rna-NM_001180760.3_MUCL30388 | cds-NP_010740.3_MUCL30388 | 99.0 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1288567-1290591:+ | gene-YDR452W_MUCL39482 | rna-NM_001180760.3_MUCL39482 | cds-NP_010740.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1231373-1233397:+ | gene-YDR452W_MUCL42920 | rna-NM_001180760.3_MUCL42920 | cds-NP_010740.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1362801-1364825:+ | gene-YDR452W_NCIM3186 | rna-NM_001180760.3_NCIM3186 | cds-NP_010740.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1302340-1304364:+ | gene-YDR452W_NCYC1407 | rna-NM_001180760.3_NCYC1407 | cds-NP_010740.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1313200-1315224:+ | gene-YDR452W_PE2H3 | rna-NM_001180760.3_PE2H3 | cds-NP_010740.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1318757-1320781:+ | gene-YDR452W_PE2H4 | rna-NM_001180760.3_PE2H4 | cds-NP_010740.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1362878-1364902:+ | gene-YDR452W_S288C | rna-NM_001180760.3_S288C | cds-NP_010740.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000004.1:252262-254286:- | gene-YDR452W_SA1 | rna-NM_001180760.3_SA1 | cds-NP_010740.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1313920-1315932:+ | gene-YDR452W_ThermosaccDry | rna-NM_001180760.3_ThermosaccDry | cds-NP_010740.3_ThermosaccDry | 99.0 | 99.4 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1329651-1331675:+ | gene-YDR452W_VR1 | rna-NM_001180760.3_VR1 | cds-NP_010740.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:356584-358608:+ | gene-YDR452W_ZTW1 | rna-NM_001180760.3_ZTW1 | cds-NP_010740.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1316996-1319026:+ | gene-YDR452W_Sparadoxus | rna-NM_001180760.3_Sparadoxus | cds-NP_010740.3_Sparadoxus | 89.5 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |