Gene name: PPH3
Reference locus (S288C): YDR075W
Gene biotype: protein_coding
Description: Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes; Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily
Top 10 interactors (score): PSY2 (0.999); TAP42 (0.999); TPD3 (0.999); PPH21 (0.998); PSY4 (0.997); CDC55 (0.995); PPM1 (0.991); RRD1 (0.991); RRD2 (0.99); PPH22 (0.982); PTC2 (0.98); RAD53 (0.977); TIP41 (0.975); SDS22 (0.963); RTS1 (0.958); CNB1 (0.938); GAC1 (0.934); GLC7 (0.933); MEC1 (0.926); DUN1 (0.918)
Homologues (species, bitscore): PPP4C (Homo sapiens, 412.9); Ppp4c (Mus musculus, 412.9); ppp4cb (Danio rerio, 414.5); ppp4c (Xenopus tropicalis, 416.0); Pp4-19C (Drosophila melanogaster, 407.9); pph-4.1 (Caenorhabditis elegans, 412.5); PPX1 (Arabidopsis thaliana, 428.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:574685-575611:+ | gene-YDR075W_AKU4011 | rna-NM_001180383.1_AKU4011 | cds-NP_010360.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:549749-550675:- | gene-YDR075W_BG1 | rna-NM_001180383.1_BG1 | cds-NP_010360.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:606981-607907:+ | gene-YDR075W_Bruggeman | rna-NM_001180383.1_Bruggeman | cds-NP_010360.1_Bruggeman | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:590559-591485:+ | gene-YDR075W_CAT1 | rna-NM_001180383.1_CAT1 | cds-NP_010360.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:565639-566565:+ | gene-YDR075W_CBS1585 | rna-NM_001180383.1_CBS1585 | cds-NP_010360.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:590797-591723:+ | gene-YDR075W_CBS436 | rna-NM_001180383.1_CBS436 | cds-NP_010360.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:562050-562976:+ | gene-YDR075W_CBS6412 | rna-NM_001180383.1_CBS6412 | cds-NP_010360.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:590715-591641:+ | gene-YDR075W_CBS6413 | rna-NM_001180383.1_CBS6413 | cds-NP_010360.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:596167-597093:+ | gene-YDR075W_CENPK1137D | rna-NM_001180383.1_CENPK1137D | cds-NP_010360.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:576540-577466:+ | gene-YDR075W_EthanolRed | rna-NM_001180383.1_EthanolRed | cds-NP_010360.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:583280-584206:+ | gene-YDR075W_FaliES1 | rna-NM_001180383.1_FaliES1 | cds-NP_010360.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000358.1:46935-47861:- | gene-YDR075W_JAY291 | rna-NM_001180383.1_JAY291 | cds-NP_010360.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:591665-592591:+ | gene-YDR075W_MUCL30387 | rna-NM_001180383.1_MUCL30387 | cds-NP_010360.1_MUCL30387 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:582063-582989:+ | gene-YDR075W_MUCL30388 | rna-NM_001180383.1_MUCL30388 | cds-NP_010360.1_MUCL30388 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:567005-567931:+ | gene-YDR075W_MUCL39482 | rna-NM_001180383.1_MUCL39482 | cds-NP_010360.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:497718-498644:+ | gene-YDR075W_MUCL42920 | rna-NM_001180383.1_MUCL42920 | cds-NP_010360.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:597079-598005:+ | gene-YDR075W_NCIM3186 | rna-NM_001180383.1_NCIM3186 | cds-NP_010360.1_NCIM3186 | 97.9 | 100.0 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:565930-566856:+ | gene-YDR075W_NCYC1407 | rna-NM_001180383.1_NCYC1407 | cds-NP_010360.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:585587-586513:+ | gene-YDR075W_PE2H3 | rna-NM_001180383.1_PE2H3 | cds-NP_010360.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:584892-585818:+ | gene-YDR075W_PE2H4 | rna-NM_001180383.1_PE2H4 | cds-NP_010360.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:597156-598082:+ | gene-YDR075W_S288C | rna-NM_001180383.1_S288C | cds-NP_010360.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:47426-48352:- | gene-YDR075W_SA1 | rna-NM_001180383.1_SA1 | cds-NP_010360.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:582657-583583:+ | gene-YDR075W_ThermosaccDry | rna-NM_001180383.1_ThermosaccDry | cds-NP_010360.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:595384-596310:+ | gene-YDR075W_VR1 | rna-NM_001180383.1_VR1 | cds-NP_010360.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:580285-581211:+ | gene-YDR075W_ZTW1 | rna-NM_001180383.1_ZTW1 | cds-NP_010360.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:585125-586051:+ | gene-YDR075W_Sparadoxus | rna-NM_001180383.1_Sparadoxus | cds-NP_010360.1_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |