Gene name: PPH22
Reference locus (S288C): YDL188C
Gene biotype: protein_coding
Description: Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
Top 10 interactors (score): CDC55 (0.999); RTS1 (0.999); TAP42 (0.999); TPD3 (0.999); TIP41 (0.997); PPM1 (0.996); PPE1 (0.996); RRD2 (0.993); PPH21 (0.982); RRD1 (0.982); PPH3 (0.982); CCT5 (0.963); CCT2 (0.961); ZDS2 (0.947); TOR2 (0.945); TOR1 (0.929); FAR11 (0.899); LST8 (0.892); CDC5 (0.888); PPM2 (0.885)
Homologues (species, bitscore): PPP2CB (Homo sapiens, 506.5); Ppp2cb (Mus musculus, 506.5); ppp2ca (Danio rerio, 507.3); ppp2ca (Xenopus tropicalis, 506.5); mts (Drosophila melanogaster, 499.6); let-92 (Caenorhabditis elegans, 501.1); PP2A-3 (Arabidopsis thaliana, 508.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:107849-108982:- | gene-YDL188C_AKU4011 | rna-NM_001180248.1_AKU4011 | cds-NP_010093.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:440183-441316:+ | gene-YDL188C_BG1 | rna-NM_001180248.1_BG1 | cds-NP_010093.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:124211-125344:- | gene-YDL188C_Bruggeman | rna-NM_001180248.1_Bruggeman | cds-NP_010093.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | MBWC01000024.1:4444-5577:+ | gene-YDL188C_CAT1 | rna-NM_001180248.1_CAT1 | cds-NP_010093.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:106389-107522:- | gene-YDL188C_CBS1585 | rna-NM_001180248.1_CBS1585 | cds-NP_010093.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:123359-124492:- | gene-YDL188C_CBS436 | rna-NM_001180248.1_CBS436 | cds-NP_010093.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:106315-107448:- | gene-YDL188C_CBS6412 | rna-NM_001180248.1_CBS6412 | cds-NP_010093.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:124359-125492:- | gene-YDL188C_CBS6413 | rna-NM_001180248.1_CBS6413 | cds-NP_010093.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:122538-123671:- | gene-YDL188C_CENPK1137D | rna-NM_001180248.1_CENPK1137D | cds-NP_010093.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:119999-121132:- | gene-YDL188C_EthanolRed | rna-NM_001180248.1_EthanolRed | cds-NP_010093.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:125106-126239:- | gene-YDL188C_FaliES1 | rna-NM_001180248.1_FaliES1 | cds-NP_010093.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000403.1:5392-6525:- | gene-YDL188C_JAY291 | rna-NM_001180248.1_JAY291 | cds-NP_010093.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:122479-123612:- | gene-YDL188C_MUCL30387 | rna-NM_001180248.1_MUCL30387 | cds-NP_010093.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:112292-113425:- | gene-YDL188C_MUCL30388 | rna-NM_001180248.1_MUCL30388 | cds-NP_010093.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:107545-108678:- | gene-YDL188C_MUCL39482 | rna-NM_001180248.1_MUCL39482 | cds-NP_010093.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:123619-124752:- | gene-YDL188C_MUCL42920 | rna-NM_001180248.1_MUCL42920 | cds-NP_010093.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:123788-124921:- | gene-YDL188C_NCIM3186 | rna-NM_001180248.1_NCIM3186 | cds-NP_010093.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:107190-108323:- | gene-YDL188C_NCYC1407 | rna-NM_001180248.1_NCYC1407 | cds-NP_010093.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:114753-115886:- | gene-YDL188C_PE2H3 | rna-NM_001180248.1_PE2H3 | cds-NP_010093.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:114763-115896:- | gene-YDL188C_PE2H4 | rna-NM_001180248.1_PE2H4 | cds-NP_010093.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:123865-124998:- | gene-YDL188C_S288C | rna-NM_001180248.1_S288C | cds-NP_010093.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000090.1:38358-39491:- | gene-YDL188C_SA1 | rna-NM_001180248.1_SA1 | cds-NP_010093.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:124865-125998:- | gene-YDL188C_ThermosaccDry | rna-NM_001180248.1_ThermosaccDry | cds-NP_010093.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:125304-126437:- | gene-YDL188C_VR1 | rna-NM_001180248.1_VR1 | cds-NP_010093.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:123039-124172:- | gene-YDL188C_ZTW1 | rna-NM_001180248.1_ZTW1 | cds-NP_010093.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:126493-127626:- | gene-YDL188C_Sparadoxus | rna-NM_001180248.1_Sparadoxus | cds-NP_010093.1_Sparadoxus | 91.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |