Gene name: PPH21
Reference locus (S288C): YDL134C
Gene biotype: protein_coding
Description: Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
Top 10 interactors (score): RTS1 (0.999); CDC55 (0.999); TPD3 (0.999); RRD2 (0.999); TAP42 (0.999); TIP41 (0.998); PPM1 (0.998); PPH3 (0.998); PPE1 (0.996); RRD1 (0.993); PPH22 (0.982); PSY2 (0.981); FAR11 (0.976); SIT4 (0.972); TOR2 (0.972); CCT5 (0.963); CCT2 (0.961); SDS22 (0.959); PSY4 (0.957); RTS3 (0.954)
Homologues (species, bitscore): PPP2CB (Homo sapiens, 505.8); Ppp2cb (Mus musculus, 505.8); ppp2ca (Danio rerio, 506.1); ppp2cb (Xenopus tropicalis, 506.1); mts (Drosophila melanogaster, 499.2); let-92 (Caenorhabditis elegans, 501.1); PP2A-3 (Arabidopsis thaliana, 506.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:204305-205414:- | gene-YDL134C_AKU4011 | rna-NM_001180193.1_AKU4011 | cds-NP_010147.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:344556-345665:+ | gene-YDL134C_BG1 | rna-NM_001180193.1_BG1 | cds-NP_010147.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:220974-222083:- | gene-YDL134C_Bruggeman | rna-NM_001180193.1_Bruggeman | cds-NP_010147.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:124569-125678:- | gene-YDL134C_CAT1 | rna-NM_001180193.1_CAT1 | cds-NP_010147.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:202568-203677:- | gene-YDL134C_CBS1585 | rna-NM_001180193.1_CBS1585 | cds-NP_010147.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:219235-220344:- | gene-YDL134C_CBS436 | rna-NM_001180193.1_CBS436 | cds-NP_010147.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:201372-202481:- | gene-YDL134C_CBS6412 | rna-NM_001180193.1_CBS6412 | cds-NP_010147.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:220730-221839:- | gene-YDL134C_CBS6413 | rna-NM_001180193.1_CBS6413 | cds-NP_010147.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:218312-219421:- | gene-YDL134C_CENPK1137D | rna-NM_001180193.1_CENPK1137D | cds-NP_010147.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:215336-216445:- | gene-YDL134C_EthanolRed | rna-NM_001180193.1_EthanolRed | cds-NP_010147.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:221057-222166:- | gene-YDL134C_FaliES1 | rna-NM_001180193.1_FaliES1 | cds-NP_010147.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000204.1:6937-8046:+ | gene-YDL134C_JAY291 | rna-NM_001180193.1_JAY291 | cds-NP_010147.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:219422-220531:- | gene-YDL134C_MUCL30387 | rna-NM_001180193.1_MUCL30387 | cds-NP_010147.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:210290-211399:- | gene-YDL134C_MUCL30388 | rna-NM_001180193.1_MUCL30388 | cds-NP_010147.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:203422-204531:- | gene-YDL134C_MUCL39482 | rna-NM_001180193.1_MUCL39482 | cds-NP_010147.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | MBVV01000146.1:7086-8195:+ | gene-YDL134C_MUCL42920 | rna-NM_001180193.1_MUCL42920 | cds-NP_010147.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:219585-220694:- | gene-YDL134C_NCIM3186 | rna-NM_001180193.1_NCIM3186 | cds-NP_010147.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:203703-204812:- | gene-YDL134C_NCYC1407 | rna-NM_001180193.1_NCYC1407 | cds-NP_010147.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:210466-211575:- | gene-YDL134C_PE2H3 | rna-NM_001180193.1_PE2H3 | cds-NP_010147.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:210470-211579:- | gene-YDL134C_PE2H4 | rna-NM_001180193.1_PE2H4 | cds-NP_010147.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:219662-220771:- | gene-YDL134C_S288C | rna-NM_001180193.1_S288C | cds-NP_010147.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000043.1:85230-86339:- | gene-YDL134C_SA1 | rna-NM_001180193.1_SA1 | cds-NP_010147.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:220818-221927:- | gene-YDL134C_ThermosaccDry | rna-NM_001180193.1_ThermosaccDry | cds-NP_010147.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:222440-223549:- | gene-YDL134C_VR1 | rna-NM_001180193.1_VR1 | cds-NP_010147.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:218746-219855:- | gene-YDL134C_ZTW1 | rna-NM_001180193.1_ZTW1 | cds-NP_010147.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:220838-221947:- | gene-YDL134C_Sparadoxus | rna-NM_001180193.1_Sparadoxus | cds-NP_010147.1_Sparadoxus | 91.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |