Gene name: PPA2
Reference locus (S288C): YMR267W
Gene biotype: protein_coding
Description: Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants; Belongs to the PPase family
Top 10 interactors (score): IPP1 (0.935); PMA1 (0.904); PMA2 (0.904); ATP1 (0.853); SAR1 (0.828); ATP3 (0.797); ATP7 (0.79); ATP2 (0.756); OLI1 (0.754); ATP14 (0.75); ATP6 (0.749); ATP5 (0.741); VMA4 (0.733); ATP4 (0.726); VMA11 (0.725); VMA16 (0.725); VMA5 (0.725); VMA3 (0.725); SPP1 (0.688); MSI1 (0.685)
Homologues (species, bitscore): PPA2 (Homo sapiens, 238.8); Ppa1 (Mus musculus, 241.9); ppa1b (Danio rerio, 244.6); ppa2 (Xenopus tropicalis, 244.2); Nurf-38 (Drosophila melanogaster, 248.4); pyp-1 (Caenorhabditis elegans, 245.4); PPa6 (Arabidopsis thaliana, 183.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:841230-842162:+ | gene-YMR267W_AKU4011 | rna-NM_001182774.1_AKU4011 | cds-NP_013994.1_AKU4011 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:112237-113169:- | gene-YMR267W_BG1 | rna-NM_001182774.1_BG1 | cds-NP_013994.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:786439-787371:+ | gene-YMR267W_Bruggeman | rna-NM_001182774.1_Bruggeman | cds-NP_013994.1_Bruggeman | 97.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:789462-790394:+ | gene-YMR267W_CAT1 | rna-NM_001182774.1_CAT1 | cds-NP_013994.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:773480-774412:+ | gene-YMR267W_CBS1585 | rna-NM_001182774.1_CBS1585 | cds-NP_013994.1_CBS1585 | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:795408-796340:+ | gene-YMR267W_CBS436 | rna-NM_001182774.1_CBS436 | cds-NP_013994.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:885035-885967:+ | gene-YMR267W_CBS6412 | rna-NM_001182774.1_CBS6412 | cds-NP_013994.1_CBS6412 | 97.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:772582-773514:+ | gene-YMR267W_CBS6413 | rna-NM_001182774.1_CBS6413 | cds-NP_013994.1_CBS6413 | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:796183-797115:+ | gene-YMR267W_CENPK1137D | rna-NM_001182774.1_CENPK1137D | cds-NP_013994.1_CENPK1137D | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:833918-834850:+ | gene-YMR267W_EthanolRed | rna-NM_001182774.1_EthanolRed | cds-NP_013994.1_EthanolRed | 97.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:779945-780877:+ | gene-YMR267W_FaliES1 | rna-NM_001182774.1_FaliES1 | cds-NP_013994.1_FaliES1 | 97.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000141.1:5659-6591:- | gene-YMR267W_JAY291 | rna-NM_001182774.1_JAY291 | cds-NP_013994.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:780288-781220:+ | gene-YMR267W_MUCL30387 | rna-NM_001182774.1_MUCL30387 | cds-NP_013994.1_MUCL30387 | 97.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:788881-789813:+ | gene-YMR267W_MUCL30388 | rna-NM_001182774.1_MUCL30388 | cds-NP_013994.1_MUCL30388 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:774568-775500:+ | gene-YMR267W_MUCL39482 | rna-NM_001182774.1_MUCL39482 | cds-NP_013994.1_MUCL39482 | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:782616-783548:+ | gene-YMR267W_MUCL42920 | rna-NM_001182774.1_MUCL42920 | cds-NP_013994.1_MUCL42920 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:801726-802658:+ | gene-YMR267W_NCIM3186 | rna-NM_001182774.1_NCIM3186 | cds-NP_013994.1_NCIM3186 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:774192-775124:+ | gene-YMR267W_NCYC1407 | rna-NM_001182774.1_NCYC1407 | cds-NP_013994.1_NCYC1407 | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:784181-785113:+ | gene-YMR267W_PE2H3 | rna-NM_001182774.1_PE2H3 | cds-NP_013994.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:785250-786182:+ | gene-YMR267W_PE2H4 | rna-NM_001182774.1_PE2H4 | cds-NP_013994.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:801772-802704:+ | gene-YMR267W_S288C | rna-NM_001182774.1_S288C | cds-NP_013994.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000002.1:5731-6663:- | gene-YMR267W_SA1 | rna-NM_001182774.1_SA1 | cds-NP_013994.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:776114-777046:+ | gene-YMR267W_ThermosaccDry | rna-NM_001182774.1_ThermosaccDry | cds-NP_013994.1_ThermosaccDry | 97.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:788718-789650:+ | gene-YMR267W_VR1 | rna-NM_001182774.1_VR1 | cds-NP_013994.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000028.1:191314-192246:+ | gene-YMR267W_ZTW1 | rna-NM_001182774.1_ZTW1 | cds-NP_013994.1_ZTW1 | 97.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:794439-795371:+ | gene-YMR267W_Sparadoxus | rna-NM_001182774.1_Sparadoxus | cds-NP_013994.1_Sparadoxus | 88.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |