Gene name: PNG1
Reference locus (S288C): YPL096W
Gene biotype: protein_coding
Description: Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease
Top 10 interactors (score): RAD23 (0.999); CDC48 (0.988); AMS1 (0.954); UFD2 (0.918); PRC1 (0.917); RAD4 (0.915); YOS9 (0.868); DSK2 (0.86); HRD1 (0.828); DDI1 (0.809); UFD1 (0.807); RPT2 (0.803); SBH1 (0.779); RPN10 (0.743); MDY2 (0.729); HRD3 (0.723); MNL1 (0.718); RRT7 (0.714); NPL4 (0.713); YDR433W (0.69)
Homologues (species, bitscore): NGLY1 (Homo sapiens, 196.4); Ngly1 (Mus musculus, 202.6); ngly1 (Danio rerio, 209.5); Pngl (Drosophila melanogaster, 131.7); png-1 (Caenorhabditis elegans, 177.6); PNG1 (Arabidopsis thaliana, 207.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:344569-345660:+ | gene-YPL096W_AKU4011 | rna-NM_001183910.1_AKU4011 | cds-NP_015229.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:550323-551414:+ | gene-YPL096W_BG1 | rna-NM_001183910.1_BG1 | cds-NP_015229.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:370575-371666:+ | gene-YPL096W_Bruggeman | rna-NM_001183910.1_Bruggeman | cds-NP_015229.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:368039-369130:+ | gene-YPL096W_CAT1 | rna-NM_001183910.1_CAT1 | cds-NP_015229.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:348642-349733:+ | gene-YPL096W_CBS1585 | rna-NM_001183910.1_CBS1585 | cds-NP_015229.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:363314-364405:+ | gene-YPL096W_CBS436 | rna-NM_001183910.1_CBS436 | cds-NP_015229.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:353311-354402:+ | gene-YPL096W_CBS6412 | rna-NM_001183910.1_CBS6412 | cds-NP_015229.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:345278-346369:+ | gene-YPL096W_CBS6413 | rna-NM_001183910.1_CBS6413 | cds-NP_015229.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:366875-367966:+ | gene-YPL096W_CENPK1137D | rna-NM_001183910.1_CENPK1137D | cds-NP_015229.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:343261-344352:+ | gene-YPL096W_EthanolRed | rna-NM_001183910.1_EthanolRed | cds-NP_015229.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:350853-351944:+ | gene-YPL096W_FaliES1 | rna-NM_001183910.1_FaliES1 | cds-NP_015229.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:13874-14965:- | gene-YPL096W_JAY291 | rna-NM_001183910.1_JAY291 | cds-NP_015229.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:361813-362904:+ | gene-YPL096W_MUCL30387 | rna-NM_001183910.1_MUCL30387 | cds-NP_015229.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:586331-587422:+ | gene-YPL096W_MUCL30388 | rna-NM_001183910.1_MUCL30388 | cds-NP_015229.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:341971-343062:+ | gene-YPL096W_MUCL39482 | rna-NM_001183910.1_MUCL39482 | cds-NP_015229.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:399659-400750:+ | gene-YPL096W_MUCL42920 | rna-NM_001183910.1_MUCL42920 | cds-NP_015229.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:366910-368001:+ | gene-YPL096W_NCIM3186 | rna-NM_001183910.1_NCIM3186 | cds-NP_015229.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:348424-349515:+ | gene-YPL096W_NCYC1407 | rna-NM_001183910.1_NCYC1407 | cds-NP_015229.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:355915-357006:+ | gene-YPL096W_PE2H3 | rna-NM_001183910.1_PE2H3 | cds-NP_015229.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:355538-356629:+ | gene-YPL096W_PE2H4 | rna-NM_001183910.1_PE2H4 | cds-NP_015229.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:366927-368018:+ | gene-YPL096W_S288C | rna-NM_001183910.1_S288C | cds-NP_015229.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:5661-6752:- | gene-YPL096W_SA1 | rna-NM_001183910.1_SA1 | cds-NP_015229.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:350651-351742:+ | gene-YPL096W_ThermosaccDry | rna-NM_001183910.1_ThermosaccDry | cds-NP_015229.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:365626-366717:+ | gene-YPL096W_VR1 | rna-NM_001183910.1_VR1 | cds-NP_015229.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:349972-351063:+ | gene-YPL096W_ZTW1 | rna-NM_001183910.1_ZTW1 | cds-NP_015229.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:351636-352727:+ | gene-YPL096W_Sparadoxus | rna-NM_001183910.1_Sparadoxus | cds-NP_015229.1_Sparadoxus | 89.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |