Gene name: PNC1
Reference locus (S288C): YGL037C
Gene biotype: protein_coding
Description: Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress
Top 10 interactors (score): NPT1 (0.997); SIR2 (0.995); QNS1 (0.983); HST4 (0.978); URH1 (0.977); HST1 (0.975); GLK1 (0.972); STF2 (0.969); HST3 (0.969); GPD1 (0.965); PNP1 (0.956); HST2 (0.956); NMA2 (0.948); SOL4 (0.946); HSP104 (0.945); RTC3 (0.941); HSP42 (0.94); BNA6 (0.94); GLC3 (0.934); TSL1 (0.931)
Homologues (species, bitscore): Naam (Drosophila melanogaster, 102.8); pnc-1 (Caenorhabditis elegans, 89.7); AT3G16190 (Arabidopsis thaliana, 51.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:429366-430016:- | gene-YGL037C_AKU4011 | rna-NM_001180902.3_AKU4011 | cds-NP_011478.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000060.1:146114-146764:+ | gene-YGL037C_BG1 | rna-NM_001180902.3_BG1 | cds-NP_011478.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:430189-430839:- | gene-YGL037C_Bruggeman | rna-NM_001180902.3_Bruggeman | cds-NP_011478.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:428349-428999:- | gene-YGL037C_CAT1 | rna-NM_001180902.3_CAT1 | cds-NP_011478.3_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:430830-431480:- | gene-YGL037C_CBS1585 | rna-NM_001180902.3_CBS1585 | cds-NP_011478.3_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:425217-425867:- | gene-YGL037C_CBS436 | rna-NM_001180902.3_CBS436 | cds-NP_011478.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:423504-424154:- | gene-YGL037C_CBS6412 | rna-NM_001180902.3_CBS6412 | cds-NP_011478.3_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:427547-428197:- | gene-YGL037C_CBS6413 | rna-NM_001180902.3_CBS6413 | cds-NP_011478.3_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:427138-427788:- | gene-YGL037C_CENPK1137D | rna-NM_001180902.3_CENPK1137D | cds-NP_011478.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:417748-418398:- | gene-YGL037C_EthanolRed | rna-NM_001180902.3_EthanolRed | cds-NP_011478.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:421009-421659:- | gene-YGL037C_FaliES1 | rna-NM_001180902.3_FaliES1 | cds-NP_011478.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000234.1:9689-10339:+ | gene-YGL037C_JAY291 | rna-NM_001180902.3_JAY291 | cds-NP_011478.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:427394-428044:- | gene-YGL037C_MUCL30387 | rna-NM_001180902.3_MUCL30387 | cds-NP_011478.3_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:430192-430842:- | gene-YGL037C_MUCL30388 | rna-NM_001180902.3_MUCL30388 | cds-NP_011478.3_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:426624-427274:- | gene-YGL037C_MUCL39482 | rna-NM_001180902.3_MUCL39482 | cds-NP_011478.3_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:435041-435691:- | gene-YGL037C_MUCL42920 | rna-NM_001180902.3_MUCL42920 | cds-NP_011478.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:427297-427947:- | gene-YGL037C_NCIM3186 | rna-NM_001180902.3_NCIM3186 | cds-NP_011478.3_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:420750-421400:- | gene-YGL037C_NCYC1407 | rna-NM_001180902.3_NCYC1407 | cds-NP_011478.3_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:423325-423975:- | gene-YGL037C_PE2H3 | rna-NM_001180902.3_PE2H3 | cds-NP_011478.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:428375-429025:- | gene-YGL037C_PE2H4 | rna-NM_001180902.3_PE2H4 | cds-NP_011478.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:427297-427947:- | gene-YGL037C_S288C | rna-NM_001180902.3_S288C | cds-NP_011478.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000021.1:127681-128331:+ | gene-YGL037C_SA1 | rna-NM_001180902.3_SA1 | cds-NP_011478.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:440375-441025:- | gene-YGL037C_ThermosaccDry | rna-NM_001180902.3_ThermosaccDry | cds-NP_011478.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:530313-530963:- | gene-YGL037C_VR1 | rna-NM_001180902.3_VR1 | cds-NP_011478.3_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:418949-419599:- | gene-YGL037C_ZTW1 | rna-NM_001180902.3_ZTW1 | cds-NP_011478.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:427848-428498:- | gene-YGL037C_Sparadoxus | rna-NM_001180902.3_Sparadoxus | cds-NP_011478.3_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |