Gene name: PLC1
Reference locus (S288C): YPL268W
Gene biotype: protein_coding
Description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1; Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation
Top 10 interactors (score): ARG82 (0.989); MSS4 (0.983); PIK1 (0.983); ISC1 (0.969); STT4 (0.956); FAB1 (0.953); TEP1 (0.945); PIS1 (0.945); INP51 (0.937); INM1 (0.926); INM2 (0.926); INP53 (0.924); VPS34 (0.921); LSB6 (0.917); INP52 (0.915); SAC1 (0.907); YMR1 (0.903); GPA2 (0.881); GPA1 (0.84); YIF1 (0.835)
Homologues (species, bitscore): PLCD4 (Homo sapiens, 264.2); Plcd3 (Mus musculus, 261.2); plcd1b (Danio rerio, 279.3); plcd1 (Xenopus tropicalis, 292.4); Plc21C (Drosophila melanogaster, 186.0); pll-1 (Caenorhabditis elegans, 190.3); PLC5 (Arabidopsis thaliana, 152.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:19539-22148:+ | gene-YPL268W_AKU4011 | rna-NM_001184082.1_AKU4011 | cds-NP_015055.1_AKU4011 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000185.1:18640-21249:- | gene-YPL268W_BG1 | rna-NM_001184082.1_BG1 | cds-NP_015055.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:36775-39384:+ | gene-YPL268W_Bruggeman | rna-NM_001184082.1_Bruggeman | cds-NP_015055.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:34745-37354:+ | gene-YPL268W_CAT1 | rna-NM_001184082.1_CAT1 | cds-NP_015055.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:23247-25856:+ | gene-YPL268W_CBS1585 | rna-NM_001184082.1_CBS1585 | cds-NP_015055.1_CBS1585 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:31640-34249:+ | gene-YPL268W_CBS436 | rna-NM_001184082.1_CBS436 | cds-NP_015055.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:28151-30760:+ | gene-YPL268W_CBS6412 | rna-NM_001184082.1_CBS6412 | cds-NP_015055.1_CBS6412 | 98.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:19399-22008:+ | gene-YPL268W_CBS6413 | rna-NM_001184082.1_CBS6413 | cds-NP_015055.1_CBS6413 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:35181-37790:+ | gene-YPL268W_CENPK1137D | rna-NM_001184082.1_CENPK1137D | cds-NP_015055.1_CENPK1137D | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:18569-21178:+ | gene-YPL268W_EthanolRed | rna-NM_001184082.1_EthanolRed | cds-NP_015055.1_EthanolRed | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:18917-21526:+ | gene-YPL268W_FaliES1 | rna-NM_001184082.1_FaliES1 | cds-NP_015055.1_FaliES1 | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000190.1:18553-21162:- | gene-YPL268W_JAY291 | rna-NM_001184082.1_JAY291 | cds-NP_015055.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:36052-38661:+ | gene-YPL268W_MUCL30387 | rna-NM_001184082.1_MUCL30387 | cds-NP_015055.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:34241-36850:+ | gene-YPL268W_MUCL30388 | rna-NM_001184082.1_MUCL30388 | cds-NP_015055.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:16377-18986:+ | gene-YPL268W_MUCL39482 | rna-NM_001184082.1_MUCL39482 | cds-NP_015055.1_MUCL39482 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:28537-31146:+ | gene-YPL268W_MUCL42920 | rna-NM_001184082.1_MUCL42920 | cds-NP_015055.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:35219-37828:+ | gene-YPL268W_NCIM3186 | rna-NM_001184082.1_NCIM3186 | cds-NP_015055.1_NCIM3186 | 98.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:22823-25432:+ | gene-YPL268W_NCYC1407 | rna-NM_001184082.1_NCYC1407 | cds-NP_015055.1_NCYC1407 | 98.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:26472-29081:+ | gene-YPL268W_PE2H3 | rna-NM_001184082.1_PE2H3 | cds-NP_015055.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:26449-29058:+ | gene-YPL268W_PE2H4 | rna-NM_001184082.1_PE2H4 | cds-NP_015055.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:35236-37845:+ | gene-YPL268W_S288C | rna-NM_001184082.1_S288C | cds-NP_015055.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000104.1:18678-21287:- | gene-YPL268W_SA1 | rna-NM_001184082.1_SA1 | cds-NP_015055.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:18918-21527:+ | gene-YPL268W_ThermosaccDry | rna-NM_001184082.1_ThermosaccDry | cds-NP_015055.1_ThermosaccDry | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:265330-267939:+ | gene-YPL268W_VR1 | rna-NM_001184082.1_VR1 | cds-NP_015055.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:25039-27648:+ | gene-YPL268W_ZTW1 | rna-NM_001184082.1_ZTW1 | cds-NP_015055.1_ZTW1 | 98.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:26956-29565:+ | gene-YPL268W_Sparadoxus | rna-NM_001184082.1_Sparadoxus | cds-NP_015055.1_Sparadoxus | 89.2 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |