Gene name: PKP2
Reference locus (S288C): YGL059W
Gene biotype: protein_coding
Description: Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
Top 10 interactors (score): PDA1 (0.885); HUL4 (0.831); RKR1 (0.819); PTC5 (0.816); TMT1 (0.797); PKP1 (0.795); RTC2 (0.785); PTC6 (0.738); PDX1 (0.706); PDB1 (0.687); YGK3 (0.685); CMK2 (0.67); YPK3 (0.66); YPK1 (0.642); YPK2 (0.642); SCH9 (0.642); CDC45 (0.641); RTK1 (0.626); YGL117W (0.626); VMA1 (0.618)
Homologues (species, bitscore): BCKDK (Homo sapiens, 112.8); Bckdk (Mus musculus, 115.5); bckdk (Danio rerio, 125.6); bckdk (Xenopus tropicalis, 95.1); Pdk (Drosophila melanogaster, 78.2); pdhk-2 (Caenorhabditis elegans, 62.0); PDK (Arabidopsis thaliana, 95.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:395214-396689:+ | gene-YGL059W_AKU4011 | rna-NM_001180924.4_AKU4011 | cds-NP_011456.5_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:8703-10178:- | gene-YGL059W_BG1 | rna-NM_001180924.4_BG1 | cds-NP_011456.5_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:397691-399166:+ | gene-YGL059W_Bruggeman | rna-NM_001180924.4_Bruggeman | cds-NP_011456.5_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:394688-396163:+ | gene-YGL059W_CAT1 | rna-NM_001180924.4_CAT1 | cds-NP_011456.5_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:398759-400234:+ | gene-YGL059W_CBS1585 | rna-NM_001180924.4_CBS1585 | cds-NP_011456.5_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:392897-394372:+ | gene-YGL059W_CBS436 | rna-NM_001180924.4_CBS436 | cds-NP_011456.5_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:382918-384393:+ | gene-YGL059W_CBS6412 | rna-NM_001180924.4_CBS6412 | cds-NP_011456.5_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:392844-394319:+ | gene-YGL059W_CBS6413 | rna-NM_001180924.4_CBS6413 | cds-NP_011456.5_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:392410-393885:+ | gene-YGL059W_CENPK1137D | rna-NM_001180924.4_CENPK1137D | cds-NP_011456.5_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:384284-385759:+ | gene-YGL059W_EthanolRed | rna-NM_001180924.4_EthanolRed | cds-NP_011456.5_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:386846-388321:+ | gene-YGL059W_FaliES1 | rna-NM_001180924.4_FaliES1 | cds-NP_011456.5_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000144.1:7943-9418:- | gene-YGL059W_JAY291 | rna-NM_001180924.4_JAY291 | cds-NP_011456.5_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:394887-396362:+ | gene-YGL059W_MUCL30387 | rna-NM_001180924.4_MUCL30387 | cds-NP_011456.5_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:397935-399410:+ | gene-YGL059W_MUCL30388 | rna-NM_001180924.4_MUCL30388 | cds-NP_011456.5_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:395067-396542:+ | gene-YGL059W_MUCL39482 | rna-NM_001180924.4_MUCL39482 | cds-NP_011456.5_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:177566-179041:- | gene-YGL059W_MUCL42920 | rna-NM_001180924.4_MUCL42920 | cds-NP_011456.5_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:392223-393698:+ | gene-YGL059W_NCIM3186 | rna-NM_001180924.4_NCIM3186 | cds-NP_011456.5_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:386600-388075:+ | gene-YGL059W_NCYC1407 | rna-NM_001180924.4_NCYC1407 | cds-NP_011456.5_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:388256-389731:+ | gene-YGL059W_PE2H3 | rna-NM_001180924.4_PE2H3 | cds-NP_011456.5_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:393306-394781:+ | gene-YGL059W_PE2H4 | rna-NM_001180924.4_PE2H4 | cds-NP_011456.5_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:392223-393698:+ | gene-YGL059W_S288C | rna-NM_001180924.4_S288C | cds-NP_011456.5_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000096.1:27391-28866:+ | gene-YGL059W_SA1 | rna-NM_001180924.4_SA1 | cds-NP_011456.5_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:387097-388572:+ | gene-YGL059W_ThermosaccDry | rna-NM_001180924.4_ThermosaccDry | cds-NP_011456.5_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:497482-498957:+ | gene-YGL059W_VR1 | rna-NM_001180924.4_VR1 | cds-NP_011456.5_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:384460-385935:+ | gene-YGL059W_ZTW1 | rna-NM_001180924.4_ZTW1 | cds-NP_011456.5_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:390083-391558:+ | gene-YGL059W_Sparadoxus | rna-NM_001180924.4_Sparadoxus | cds-NP_011456.5_Sparadoxus | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |