Gene name: PKH2
Reference locus (S288C): YOL100W
Gene biotype: protein_coding
Description: 3-phosphoinositide dependent protein kinase-1; Serine/threonine-protein kinase PKH2; Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily
Top 10 interactors (score): PKH1 (0.999); PKC1 (0.984); PIL1 (0.936); LSP1 (0.927); PKH3 (0.847); SLM1 (0.838); YPK1 (0.809); SCH9 (0.808); YPK2 (0.794); LCB1 (0.786); TSC11 (0.744); YPK3 (0.719); TOR1 (0.689); TOR2 (0.661); ORM1 (0.658); ISC1 (0.612); LCB2 (0.608); TEP1 (0.606); NCE102 (0.583); SUR7 (0.576)
Homologues (species, bitscore): PDPK1 (Homo sapiens, 286.2); Pdpk1 (Mus musculus, 287.7); pdpk1b (Danio rerio, 273.5); pdpk1 (Xenopus tropicalis, 281.6); Pdk1 (Drosophila melanogaster, 233.0); pdk-1 (Caenorhabditis elegans, 207.6); PDK1 (Arabidopsis thaliana, 226.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:112554-115799:+ | gene-YOL100W_AKU4011 | rna-NM_001183354.1_AKU4011 | cds-NP_014541.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000172.1:77668-80913:+ | gene-YOL100W_BG1 | rna-NM_001183354.1_BG1 | cds-NP_014541.1_BG1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:114135-117380:+ | gene-YOL100W_Bruggeman | rna-NM_001183354.1_Bruggeman | cds-NP_014541.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:113009-116254:+ | gene-YOL100W_CAT1 | rna-NM_001183354.1_CAT1 | cds-NP_014541.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:106993-110238:+ | gene-YOL100W_CBS1585 | rna-NM_001183354.1_CBS1585 | cds-NP_014541.1_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:112274-115519:+ | gene-YOL100W_CBS436 | rna-NM_001183354.1_CBS436 | cds-NP_014541.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:107155-110400:+ | gene-YOL100W_CBS6412 | rna-NM_001183354.1_CBS6412 | cds-NP_014541.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:113856-117101:+ | gene-YOL100W_CBS6413 | rna-NM_001183354.1_CBS6413 | cds-NP_014541.1_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:123201-126446:+ | gene-YOL100W_CENPK1137D | rna-NM_001183354.1_CENPK1137D | cds-NP_014541.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:110157-113402:+ | gene-YOL100W_EthanolRed | rna-NM_001183354.1_EthanolRed | cds-NP_014541.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:112484-115729:+ | gene-YOL100W_FaliES1 | rna-NM_001183354.1_FaliES1 | cds-NP_014541.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000160.1:27739-30984:- | gene-YOL100W_JAY291 | rna-NM_001183354.1_JAY291 | cds-NP_014541.1_JAY291 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:118339-121584:+ | gene-YOL100W_MUCL30387 | rna-NM_001183354.1_MUCL30387 | cds-NP_014541.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:121520-124765:+ | gene-YOL100W_MUCL30388 | rna-NM_001183354.1_MUCL30388 | cds-NP_014541.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:114915-118160:+ | gene-YOL100W_MUCL39482 | rna-NM_001183354.1_MUCL39482 | cds-NP_014541.1_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:130687-133932:+ | gene-YOL100W_MUCL42920 | rna-NM_001183354.1_MUCL42920 | cds-NP_014541.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:129126-132371:+ | gene-YOL100W_NCIM3186 | rna-NM_001183354.1_NCIM3186 | cds-NP_014541.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:121511-124756:+ | gene-YOL100W_NCYC1407 | rna-NM_001183354.1_NCYC1407 | cds-NP_014541.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:104812-108057:+ | gene-YOL100W_PE2H3 | rna-NM_001183354.1_PE2H3 | cds-NP_014541.1_PE2H3 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:115792-119037:+ | gene-YOL100W_PE2H4 | rna-NM_001183354.1_PE2H4 | cds-NP_014541.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:129237-132482:+ | gene-YOL100W_S288C | rna-NM_001183354.1_S288C | cds-NP_014541.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:97106-100351:+ | gene-YOL100W_SA1 | rna-NM_001183354.1_SA1 | cds-NP_014541.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:111492-114737:+ | gene-YOL100W_ThermosaccDry | rna-NM_001183354.1_ThermosaccDry | cds-NP_014541.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:112061-115306:+ | gene-YOL100W_VR1 | rna-NM_001183354.1_VR1 | cds-NP_014541.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000031.1:111192-114437:+ | gene-YOL100W_ZTW1 | rna-NM_001183354.1_ZTW1 | cds-NP_014541.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:114634-117882:+ | gene-YOL100W_Sparadoxus | rna-NM_001183354.1_Sparadoxus | cds-NP_014541.1_Sparadoxus | 88.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |