Gene name: PKH1
Reference locus (S288C): YDR490C
Gene biotype: protein_coding
Description: 3-phosphoinositide dependent protein kinase-1; Serine/threonine-protein kinase PKH1; Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh2p; PKH1 has a paralog, PKH2, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily
Top 10 interactors (score): PKH2 (0.999); PIL1 (0.989); PKC1 (0.979); LSP1 (0.963); YPK1 (0.918); SCH9 (0.903); SLM1 (0.874); TSC11 (0.858); YPK2 (0.854); PKH3 (0.845); NCE102 (0.829); TOR1 (0.82); TOR2 (0.804); LCB1 (0.799); ORM1 (0.776); ISC1 (0.776); ORM2 (0.742); YPK3 (0.74); LST8 (0.739); EIS1 (0.69)
Homologues (species, bitscore): PDPK1 (Homo sapiens, 276.6); Pdpk1 (Mus musculus, 278.1); pdpk1a (Danio rerio, 273.1); pdpk1 (Xenopus tropicalis, 275.8); Pdk1 (Drosophila melanogaster, 226.5); pdk-1 (Caenorhabditis elegans, 203.8); AT3G10540 (Arabidopsis thaliana, 223.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1371952-1374252:- | gene-YDR490C_AKU4011 | rna-NM_001180798.3_AKU4011 | cds-NP_010778.3_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000073.1:13507-15807:- | gene-YDR490C_BG1 | rna-NM_001180798.3_BG1 | cds-NP_010778.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1403299-1405599:- | gene-YDR490C_Bruggeman | rna-NM_001180798.3_Bruggeman | cds-NP_010778.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1380453-1382753:- | gene-YDR490C_CAT1 | rna-NM_001180798.3_CAT1 | cds-NP_010778.3_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1366194-1368494:- | gene-YDR490C_CBS1585 | rna-NM_001180798.3_CBS1585 | cds-NP_010778.3_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1385548-1387848:- | gene-YDR490C_CBS436 | rna-NM_001180798.3_CBS436 | cds-NP_010778.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1361836-1364136:- | gene-YDR490C_CBS6412 | rna-NM_001180798.3_CBS6412 | cds-NP_010778.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1384851-1387151:- | gene-YDR490C_CBS6413 | rna-NM_001180798.3_CBS6413 | cds-NP_010778.3_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1430664-1432964:- | gene-YDR490C_CENPK1137D | rna-NM_001180798.3_CENPK1137D | cds-NP_010778.3_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1375244-1377544:- | gene-YDR490C_EthanolRed | rna-NM_001180798.3_EthanolRed | cds-NP_010778.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1378797-1381097:- | gene-YDR490C_FaliES1 | rna-NM_001180798.3_FaliES1 | cds-NP_010778.3_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000026.1:77042-79342:- | gene-YDR490C_JAY291 | rna-NM_001180798.3_JAY291 | cds-NP_010778.3_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1385797-1388097:- | gene-YDR490C_MUCL30387 | rna-NM_001180798.3_MUCL30387 | cds-NP_010778.3_MUCL30387 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1367817-1370117:- | gene-YDR490C_MUCL30388 | rna-NM_001180798.3_MUCL30388 | cds-NP_010778.3_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1357679-1359979:- | gene-YDR490C_MUCL39482 | rna-NM_001180798.3_MUCL39482 | cds-NP_010778.3_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1300470-1302770:- | gene-YDR490C_MUCL42920 | rna-NM_001180798.3_MUCL42920 | cds-NP_010778.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1431891-1434191:- | gene-YDR490C_NCIM3186 | rna-NM_001180798.3_NCIM3186 | cds-NP_010778.3_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1371466-1373766:- | gene-YDR490C_NCYC1407 | rna-NM_001180798.3_NCYC1407 | cds-NP_010778.3_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1382309-1384609:- | gene-YDR490C_PE2H3 | rna-NM_001180798.3_PE2H3 | cds-NP_010778.3_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1387883-1390183:- | gene-YDR490C_PE2H4 | rna-NM_001180798.3_PE2H4 | cds-NP_010778.3_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1431968-1434268:- | gene-YDR490C_S288C | rna-NM_001180798.3_S288C | cds-NP_010778.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000004.1:182871-185171:+ | gene-YDR490C_SA1 | rna-NM_001180798.3_SA1 | cds-NP_010778.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1383019-1385319:- | gene-YDR490C_ThermosaccDry | rna-NM_001180798.3_ThermosaccDry | cds-NP_010778.3_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1398754-1401054:- | gene-YDR490C_VR1 | rna-NM_001180798.3_VR1 | cds-NP_010778.3_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:425686-427986:- | gene-YDR490C_ZTW1 | rna-NM_001180798.3_ZTW1 | cds-NP_010778.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1385833-1388130:- | gene-YDR490C_Sparadoxus | rna-NM_001180798.3_Sparadoxus | cds-NP_010778.3_Sparadoxus | 86.8 | 99.7 | Verified | 1 | 1 | 1 | False | True | False | False | False |