Gene name: PIN3
Reference locus (S288C): YPR154W
Gene biotype: protein_coding
Description: [PSI+] inducibility protein 3; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication
Top 10 interactors (score): LSB1 (0.999); LAS17 (0.994); BBC1 (0.92); VRP1 (0.909); SUP35 (0.899); BZZ1 (0.889); CDC25 (0.868); BUD5 (0.863); YCL068C (0.863); LTE1 (0.863); RSP5 (0.852); ACT1 (0.834); MYO3 (0.828); PIN2 (0.816); BOI2 (0.791); URE2 (0.779); PAN1 (0.777); PIN4 (0.764); ABP1 (0.762); PLC1 (0.758)
Homologues (species, bitscore): GRB2 (Homo sapiens, 76.6); Grb2 (Mus musculus, 76.6); grb2a (Danio rerio, 80.1); grb2 (Xenopus tropicalis, 76.3); Dap160 (Drosophila melanogaster, 57.8); sem-5 (Caenorhabditis elegans, 67.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:800707-801372:+ | gene-YPR154W_AKU4011 | rna-NM_001184251.1_AKU4011 | cds-NP_015480.1_AKU4011 | 96.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:96013-96663:- | gene-YPR154W_BG1 | rna-NM_001184251.1_BG1 | cds-NP_015480.1_BG1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:880998-881648:+ | gene-YPR154W_Bruggeman | rna-NM_001184251.1_Bruggeman | cds-NP_015480.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:923271-923927:+ | gene-YPR154W_CAT1 | rna-NM_001184251.1_CAT1 | cds-NP_015480.1_CAT1 | 98.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:804945-805610:+ | gene-YPR154W_CBS1585 | rna-NM_001184251.1_CBS1585 | cds-NP_015480.1_CBS1585 | 96.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:819062-819712:+ | gene-YPR154W_CBS436 | rna-NM_001184251.1_CBS436 | cds-NP_015480.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:807692-808360:+ | gene-YPR154W_CBS6412 | rna-NM_001184251.1_CBS6412 | cds-NP_015480.1_CBS6412 | 96.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:802399-803073:+ | gene-YPR154W_CBS6413 | rna-NM_001184251.1_CBS6413 | cds-NP_015480.1_CBS6413 | 95.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:834560-835207:+ | gene-YPR154W_CENPK1137D | rna-NM_001184251.1_CENPK1137D | cds-NP_015480.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:1122855-1123508:+ | gene-YPR154W_EthanolRed | rna-NM_001184251.1_EthanolRed | cds-NP_015480.1_EthanolRed | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:802402-803055:+ | gene-YPR154W_FaliES1 | rna-NM_001184251.1_FaliES1 | cds-NP_015480.1_FaliES1 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000437.1:15141-15791:+ | gene-YPR154W_JAY291 | rna-NM_001184251.1_JAY291 | cds-NP_015480.1_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:821182-821832:+ | gene-YPR154W_MUCL30387 | rna-NM_001184251.1_MUCL30387 | cds-NP_015480.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:821927-822577:+ | gene-YPR154W_MUCL30388 | rna-NM_001184251.1_MUCL30388 | cds-NP_015480.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:797458-798123:+ | gene-YPR154W_MUCL39482 | rna-NM_001184251.1_MUCL39482 | cds-NP_015480.1_MUCL39482 | 96.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:860907-861557:+ | gene-YPR154W_MUCL42920 | rna-NM_001184251.1_MUCL42920 | cds-NP_015480.1_MUCL42920 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:834548-835195:+ | gene-YPR154W_NCIM3186 | rna-NM_001184251.1_NCIM3186 | cds-NP_015480.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:806064-806723:+ | gene-YPR154W_NCYC1407 | rna-NM_001184251.1_NCYC1407 | cds-NP_015480.1_NCYC1407 | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:812781-813431:+ | gene-YPR154W_PE2H3 | rna-NM_001184251.1_PE2H3 | cds-NP_015480.1_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:812429-813079:+ | gene-YPR154W_PE2H4 | rna-NM_001184251.1_PE2H4 | cds-NP_015480.1_PE2H4 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:834565-835212:+ | gene-YPR154W_S288C | rna-NM_001184251.1_S288C | cds-NP_015480.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000028.1:126817-127467:+ | gene-YPR154W_SA1 | rna-NM_001184251.1_SA1 | cds-NP_015480.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:801844-802497:+ | gene-YPR154W_ThermosaccDry | rna-NM_001184251.1_ThermosaccDry | cds-NP_015480.1_ThermosaccDry | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:824281-824931:+ | gene-YPR154W_VR1 | rna-NM_001184251.1_VR1 | cds-NP_015480.1_VR1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:805218-805871:+ | gene-YPR154W_ZTW1 | rna-NM_001184251.1_ZTW1 | cds-NP_015480.1_ZTW1 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:807261-807893:+ | gene-YPR154W_Sparadoxus | rna-NM_001184251.1_Sparadoxus | cds-NP_015480.1_Sparadoxus | 88.8 | 97.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |